Abstracts tagged "monocytes and pathogenesis"

Abstract Number: 2342 • ACR/ARHP Annual Meeting 2017
Transcriptomic Analysis Reveals Mitochondrial and Monocyte Dysfunctions Are Linked to the Interferonopathy of Juvenile Dermatomyositis
Claire Deakin¹, Elizabeth Rosser¹, Lucy Marshall¹, Meredyth Wilkinson², Aziza Khabbush³, Stefania Simou¹, Georg Otto³, Stefanie Dowle³, Daniel Kelberman³, Simon Yona², Simon Eaton³ and Lucy R Wedderburn¹, ¹Infection, Immunity and Inflammation Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom, ²Division of Medicine, University College London, London, United Kingdom, ³Genetics and Genomic Medicine Programme, UCL Great Ormond Street Institute of Child Health, University College London, United Kingdom, London, United Kingdom
Background/Purpose: Although type I interferon (IFN1) and endoplasmic reticulum (ER) stress have been implicated in pathogenesis of juvenile dermatomyositis (JDM), little else is known about…
Abstract Number: 2874 • ACR/ARHP Annual Meeting 2016
CD16+monocytes Are Enriched and Functionally Exacerbated in Driving B Cell Activation Under Systemic Lupus Erythematosus Condition
Huaqun Zhu¹, Yin Su², Fanlei Hu³ and Liling Xu³, ¹Department of Rheumatology and Immunology/Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ²Department of Rheumatology and Immunology,Clinical Immunology Center, Peking University People's Hospital, Beijing, China, ³Peking University People's Hospital, Beijing, China
Background/Purpose: Systemic lupus erythematosus(SLE) was an autoimmune disease characterized by extensive B cell activation and autoantibody production. Human peripheral monocytes could be categorized into three subsets…