Abstracts tagged "MMP and VDIPEN"

Abstract Number: 2089 • 2012 ACR/ARHP Annual Meeting
High Local Cathepsin Activity in a Murine Rheumatoid Arthritis Model, but Not in an Osteoarthritis Model, Explains the Difference in Cartilage Vdipen Neoepitope Formation
Eline A. Vermeij¹, Marije I. Koenders², Onno J. Arntz³, Miranda B. Bennink¹, Arjen B. Blom⁴, Peter L.E.M. van Lent⁵, Wim B. van den Berg¹ and Fons A.J. van de Loo¹, ¹Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ²Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, ³Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁴Rheumatology Research & Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, ⁵Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint inflammation and connective tissue destruction. On the other hand, osteoarthritis (OA) is regarded as…

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