ACR Meeting Abstracts

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Abstracts tagged "mitochondria and uric acid"

  • Abstract Number: 3075 • 2016 ACR/ARHP Annual Meeting

    Mitochondrial Genetic Variation, Copy Number and Susceptibility to Gout in the New Zealand Polynesian Population

    Tony R. Merriman1, James Boocock2, Nicola Dalbeth3, Lisa K. Stamp4, Eli A. Stahl5, Hyon K. Choi6, Elizabeth Matisoo-Smith7 and Anna Gosling8, 1Biochemistry Dept, PO Box 56, University of Otago, Dunedin, New Zealand, 2University of Otago, Dunedin, New Zealand, 3University of Auckland, Auckland, New Zealand, 4University of Otago, Christchurch, New Zealand, 5Divisions of Rheumatology and Genetics, Brigham and Women's Hospital, Boston, MA, 6Rheumatology, Allergy and Immunology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 7Anatomy, University of Otago, Dunedin, New Zealand, 8Biochemistry, University of Otago, Dunedin, New Zealand

    Background/Purpose: Mitochondria play a central role in induction of an NLRP3 inflammatory response essential for gouty pathology. Mitochondria are in part self-encoding, possessing a 16.5…
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