Abstracts tagged "mitochondria and systemic lupus erythematosus (SLE)"

Abstract Number: 1090 • 2018 ACR/ARHP Annual Meeting
Cell-Free Mitochondrial DNA As a Novel Biomarker in Systemic Lupus Erythematosus
Bhargavi Duvvuri¹, Richard Moore¹ and Christian Lood², ¹Division of Rheumatology, University of Washington, Seattle, WA, ²Department of Medicine, Division of Rheumatology, University of Washington, Seattle, WA
Background/Purpose: We recently described a fundamental role for mitochondrial (mt)-mediated inflammation in systemic lupus erythematosus (SLE). Briefly, mtROS promoted formation of neutrophil extracellular traps (NETs),…
Abstract Number: 1666 • 2017 ACR/ARHP Annual Meeting
Anti-Mitochondrial Autoantibodies in Systemic Lupus Erythematosus and Their Association with Disease Manifestations
Yann Becker¹, Renee Claude Loignon¹, Genevieve Marcoux¹, Anne-Sophie Julien², Imene Melki¹, Lihi Eder³, Eric Wagner¹, Martin Pelletier¹, Marie-Josee Hebert⁴, Clemence Belleannee¹, Joyce Rauch⁵, Melanie Dieude⁴, Paul R. Fortin⁶ and Eric Boilard¹, ¹CHU de Quebec and Universite Laval, Quebec City, QC, Canada, ²CHU de Quebec - Universite Laval, Quebec City, QC, Canada, ³Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada, ⁴CHUM and Universite de Montreal, Montreal, QC, Canada, ⁵McGill University, Montreal, QC, Canada, ⁶Medicine, CHU de Quebec - Universite de Laval, Quebec, QC, Canada
- Background/Purpose: Eukaryotic cells contain organelles called mitochondria that govern energy supply and control of cell death. Whereas damaged organs or activated cells can extrude…
Abstract Number: 2072 • 2015 ACR/ARHP Annual Meeting
Mitochondrial Reactive Oxygen Species Modulate Autoimmunity in Systemic Lupus Erythematosus
Luz P. Blanco¹, Christian Lood², Monica Purmalek³, Suk See DeRavin⁴, Carolyne K. Smith³, Carmelo Carmona-Rivera³, Harry Malech⁴, Jeffrey Ledbetter⁵, Keith B. Elkon⁶ and Mariana J. Kaplan¹, ¹Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Internal Medicine, University of Washington, Seattle, WA, ³Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ⁴NIAID/NIH, Bethesda, MD, ⁵University of Washington, Seattle, WA, ⁶Department of Medicine & Immunology, University of Washington, Seattle, WA
Background/Purpose: Dysregulation in the formation of neutrophil extracellular traps (NETs) may contribute to modification and externalization of autoantigens and to organ damage in diverse autoimmune…
Abstract Number: 2498 • 2012 ACR/ARHP Annual Meeting
Biomarkers of Mitochondrial Dysfunction Correlate with Disease Activity in SLE
Zhi-Wei Lai¹, Tiffany Telarico², Robert Hanczko¹, Adam Bartos¹, Lisa Francis³, Hajra I. Tily⁴, Ricardo Garcia¹, Maha M. Dawood⁵, Jianghong Yu⁶, Ashwini Shadakshari⁶, Paul E. Phillips⁷ and Andras Perl⁸, ¹Medicine, SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Medicine/Rheumatology, SUNY upstate medical university, Syracuse, NY, ⁴SUNY, NY, ⁵Medicine/Rheumatology, SUNY Upstate, Syracuse, NY, ⁶Medicine/Rheumatology, SUNY Upstate Medical University, Syracuse, NY, ⁷Dept of Medicine/Div of Rheum, SUNY-Upstate Medical Univ, Syracuse, NY, ⁸Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Systemic lupus erythematosus (SLE) patients’ T cells exhibit mitochondrial dysfunction, characterized by the persistent elevation of the mitochondrial transmembrane potential (Δψm) or mitochondrial hyperpolarization…
Abstract Number: 2345 • 2012 ACR/ARHP Annual Meeting
HRES-1/RAB4-Mediated Loss of DRP1 Inhibits Mitophagy, Promotes Accumulation of Mitochondria and Serves As Target for Treatment in SLE
Tiffany Telarico¹, David Fernandez¹, Zachary A. Oaks², Gergely Talaber³, Mark Haas⁴, Michael P. Madaio⁵ and Andras Perl⁶, ¹Medicine, SUNY Upstate Medical University, Syracuse, NY, ²SUNY, Syracuse, NY, ³Medicine, SUNY, Syracuse, NY, ⁴Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Medical College of Georgia, Augusta, GA, ⁶Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: T cells from patients with systemic lupus erythematosus (SLE) exhibit accumulation of mitochondria and activation of the mammalian target of rapamycin (mTOR). Although mTOR…
Abstract Number: 1455 • 2012 ACR/ARHP Annual Meeting
Mitochondrial Dysfunction in the Liver of Lupus-Prone MRL/Lpr Mice Prior to Disease Onset
Zachary A. Oaks¹, Tiffany Telarico² and Andras Perl³, ¹SUNY, Syracuse, NY, ²Medicine, SUNY Upstate Medical University, Syracuse, NY, ³Dept of Medicine, SUNY Upstate Medical University, Syracuse, NY
Background/Purpose: Liver dysfunction, characterized by serum elevation of liver enzymes, is detectable in 20% of patients with systemic lupus erythematosus (SLE.) Males had a higher…

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