ACR Meeting Abstracts

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Abstracts tagged "mitochondria and rheumatoid arthritis (RA)"

  • Abstract Number: 1063 • 2018 ACR/ARHP Annual Meeting

    Role of Mitochondrial-Bound HK2 in Rheumatoid Arthritis Fibroblast-like Synoviocytes

    Patricia Oliveira1, Marta Fernandez Bustmanate2, Ricard Garcia Carbonell3, Elsa Sanchez-Lopez4, Teresina Laragione5, Percio S. Gulko6, Gary S. Firestein7, Anne N Murphy3, Shigeki Miyamoto8 and Monica Guma7,9, 1Medicine, UCSD, San Diego, CA, 2Medicine, UCSD, La Jolla, CA, 3Pharmacology, UCSD, San Diego, CA, 4Department of Pharmacology, School of Medicine. UCSD., La Jolla, CA, 5Medicine/Rheumatology, Icahn School of Medicine at Mount Sinai, New York, NY, 6Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 7Medicine, University of California San Diego, La Jolla, CA, 8Pharmacology, UCSD, La Jolla, CA, 9Medicine, Autonomous University of Barcelona, Bellatera, Spain

    Background/Purpose: Hexokinases (HKs) catalyze the first step in glucose metabolism. HK2 constitutes the principal inducible isoform with a restricted distribution in normal adult tissues. Fibroblast-like…
  • Abstract Number: 1417 • 2017 ACR/ARHP Annual Meeting

    Mitophagy Defect in Fibroblast-like Synoviocytes of Rheumatoid Arthritis Is Improved By Pyruvate Treatment

    Jeong Yeon Kim1,2, ShinEui Kang3,4, Hyun Jung Yoo1,5, Ji Soo Park1,2, Sehui Shon1,2, Eun Young Lee2, Eun Bong Lee5 and Yeong Wook Song1,6, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., Seoul, Korea, Republic of (South), 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea., seoul, Korea, Republic of (South), 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Korea, Republic of (South), 5Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), 6Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South)

    Background/Purpose: Fibroblast-like synoviocytes (FLS) in the synovial intimal lining produce pro-inflammatory cytokines resulting in increase of joint inflammation. Recent studies about the cellular metabolism in…
  • Abstract Number: 2570 • 2016 ACR/ARHP Annual Meeting

    Pyruvate Regulates Reactive Oxygen Species (ROS) Production, Dysfunction and Aberrant Metabolism of Mitochondria in Fibroblast-like Synoviocytes of Rheumatoid Arthritis

    Jeong Yeon Kim1,2, Shin Eui Kang2,3, Hyun Jung Yoo3,4, Ji Soo Park1, Eun Young Lee2, Eun Bong Lee2 and Yeong Wook Song3,4, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea, The Republic of, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, The Republic of, 3Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea, 4Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Background/Purpose:  In rheumatoid arthritis (RA), fibroblast-like synoviocyte (FLS) is a key component of invasive synovium and mediates inflammation and destruction of joint. Recently, change of…
  • Abstract Number: 1666 • 2015 ACR/ARHP Annual Meeting

    Mitochondrial Haplogroups in Patients with Rheumatoid Arthritis with Respect to Biological Treatment

    Pernille Hurup Duhn1, Jacob Sode2,3,4, Christian Hagen5, Michael Christiansen5,6 and Henning Locht4, 1Department of Rheumatology, Frederiksberg Hospital, University of Copenhagen, Copenhagen, Denmark, 2Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark, 3Department of Autoimmunology and Biomarkers, Statens Serum Institut, Copenhagen, Denmark, 4Department of Rheumatology, Frederiksberg Hospital, Frederiksberg, Denmark, 5Department of Congenital Disorders, Statens Serum Institut, Copenhagen, Copenhagen, Denmark, 6Department of Biomedical Sciences, Faculty of Health and Life Science, University of Copenhagen, Copenhagen, Denmark

    Background/Purpose: Throughout evolution mutations in mitochondrial DNA (mtDNA) have accumulated sequentially subdividing the human population into different haplogroups classificed from A-Z. Specific mtDNA haplogroups have…
  • Abstract Number: 1742 • 2014 ACR/ARHP Annual Meeting

    Depletion of Reactive Oxygen Species Biases T Cells to Proinflammatory Cytokine Production in Rheumatoid Arthritis

    Zhen Yang1, Eric L. Matteson2, Jorg J. Goronzy1 and Cornelia M. Weyand3, 1Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, 2Rheumatology, Mayo Clinic, Rochester, MN, 3Medicine, Stanford University School of Medicine, Stanford, CA

    Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease, genetically associated with polymorphisms in HLA class II molecules. CD4 cells produce proinflammatory cytokines and orchestrate…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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