Abstracts tagged "mitochondria and inflammasome activation"

Abstract Number: 2014 • 2019 ACR/ARP Annual Meeting
Loss-of-function of the DNA Repair Nuclease MRE11A Induces Mitochondrial Failure and Tissue Inflammation in Rheumatoid Arthritis
Yinyin Li ¹, Yi Shen ¹, Ke Jin ¹, Zhenke Wen ¹, Wenqiang Cao ¹, Bowen Wu ¹, Ru Wen ¹, Lu Tian ¹, Gerald Berry ¹, Jorg Goronzy ¹ and Cornelia Weyand¹, ¹Stanford University, Stanford, CA
Background/Purpose: Patients with rheumatoid arthritis (RA) accumulate tissue-invasive, pro-inflammatory CD4+ T cells. Such T cells are metabolically reprogrammed, favoring cytokine production, lipogenesis and membrane formation…

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Abstracts tagged "mitochondria and inflammasome activation"

Loss-of-function of the DNA Repair Nuclease MRE11A Induces Mitochondrial Failure and Tissue Inflammation in Rheumatoid Arthritis