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Abstracts tagged "Migration inhibitory factor (MIF)"

  • Abstract Number: 875 • ACR/ARHP Annual Meeting 2012

    Discovery of Pharmacologic MIF Antagonists by Structure-Based Molecular Design

    William L. Jorgensen1, Alissa A. Hare1, Zoe Cournia1, Sunilkumar Gandavadi1, Xin Du1, Lin Leng1 and Richard J. Bucala2, 1Yale University, New Haven, CT, 2Rheum/Dept of Int Med, Yale University School of Med, New Haven, CT

    Background/Purpose: Cytokine inhibition is becoming a mainstay for the therapy of autoimmunity but current antibody-based approaches remain limited by high cost, parenteral administration, and anti-idiotype…
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