Abstracts tagged "MicroRNA and systemic sclerosis"

Abstract Number: 2702 • 2014 ACR/ARHP Annual Meeting
Key Roles for Mir-155 and Mir-21 in Progressive Lung Fibrosis Associated with Systemic Sclerosis (SSc-ILD)
Romy Christmann¹, Percival D Sampaio-Barros², Claudia Borges³, Carlos Carvalho⁴, Ronaldo A Kairalla⁵, Edwin R. Parra⁶, Giuseppina Stifano⁷, Avi Spira⁸, Robert W. Simms⁹, Vera L. Capelozzi⁶ and Robert Lafyatis¹⁰, ¹Rheumatology, Arthritis Center/Rheumatology, Boston, MA, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Rheumatology, CEUMA University, Sao Luis do Maranhao, Brazil, ⁴Pulmonology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁵Division of Pulmonology - Heart Institute (InCor) - Medical School, University of Sao Paulo, Sao Paulo, Brazil, ⁶Pathology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil, ⁷Rheumatology, Boston University Medical Center, Boston, MA, ⁸Boston University School of Medicine, Boston, MA, ⁹Rheumatology, Boston University School of Medicine, Boston, MA, ¹⁰Arthritis Center, Boston University, Boston, MA
Background/Purpose We have already reported that macrophage activation, and up-regulation of TGF-beta- and interferon-regulated genes are involved in progressive SSc-ILD. Micro-rnas (miRNA) are a class…
Abstract Number: 659 • 2013 ACR/ARHP Annual Meeting
Circulating Cell-free microRNAs in Systemic Sclerosis
Samantha Steen¹, Anting L. Carlsen², Line V. Iversen¹, Christoffer T. Nielsen³, Christian Lood⁴, Anders A. Bengtsson⁴ and Niels H. H. Heegaard¹, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ²Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ³Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden
Background/Purpose: microRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression through target mRNAs and are involved in important physiological and pathological…

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