Abstracts tagged "MicroRNA and SLE"

Abstract Number: 1765 • 2015 ACR/ARHP Annual Meeting
MiR155 Deficient Mice Show Reduced Disease Severity in Pristane-Induced Lupus
Harald Leiss¹, Wilhelm Salzberger², Barbara Schwarzecker³, Irina Gessl¹, Nicolas Kozakowski⁴, Stephan Blüml⁵, Antonia Puchner¹, Birgit Niederreiter⁶, Carl-Walter Steiner², Josef S. Smolen⁷ and Georg H. Stummvoll², ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁶Rheumatology, Internal Medicine III, Medical University of Vienna, Vienna, Austria, ⁷Division of Rheumatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria
Background/Purpose: MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…
Abstract Number: 650 • 2014 ACR/ARHP Annual Meeting
Decreased Severity of Pristane Induced Lupus in miR155 Deficient Mice
Harald Leiss¹, Wilhelm Salzberger², Irina Gessl¹, Barbara Schwarzecker³, Nicolas Kozakowski⁴, Stephan Blüml¹, Antonia Puchner¹, Birgit Niederreiter³, Carl-Walter Steiner⁵, Josef Smolen³ and Georg H. Stummvoll², ¹Department of Rheumatology, Medical University of Vienna, Vienna, Austria, ²Rheumatology, Medical University of Vienna, Vienna, Austria, ³Department of Internal Medicine III, Division of Rheumatology, Medical University of Vienna, Vienna, Austria, ⁴Department of Pathology, Medical University of Vienna, Vienna, Austria, ⁵Division of Rheumatology, Medical University of Vienna, Vienna, Austria
Background/Purpose MicroRNAs (miRs) are an important class of regulators of gene expression that are associated with a variety of biological functions. Deregulation of endogenous miR155…
Abstract Number: 570 • 2013 ACR/ARHP Annual Meeting
In Vivo Therapeutic Success Of Microrna-155 (miR-155) Antagomir In a Mouse Model Of Lupus Pulmonary Hemorrhage
Shiyu Zhou¹, Dong Liang², Xinfang Huang³, Chunyuan Xiao³, Yuanjia Tang¹, Qian Jia³, John B. Harley^4,5 and Nan Shen^6,7,8, ¹Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ³Shanghai Institute of Rheumatology, Shanghai Institute of Rheumatology ,Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China, ⁴Division of Rheumatology and The Center for Autoimmune Genomics & Etiology, University of Cincinnati, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, ⁵US Department of Veterans Affairs Medical Center, Cincinnati, OH, ⁶Rheumatology, Shanghai Institutes for Biological Sciences Chinese Academy of Sciences & Shanghai Jiao Tong University School of Medicine, Shanghai, OH, China, ⁷Division of Rheumatology & the Center for Autoimmune Genomics and Etiology (CAGE), Cincinnati Children’s Hospital Medical Center, cincinnati, OH, ⁸Shanghai Institute of Rheumatology ,Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China
Background/Purpose: MiR-155 is a typical pleiotropic miRNA that participates in various aspects of immunity. Previous in vitro studies indicated that it is both a pro-inflammatory and an anti-inflammatory…

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