Abstracts tagged "MicroRNA and fibroblasts"

Abstract Number: 542 • ACR/ARHP Annual Meeting 2015
Reduced Expression of Mir-204 in Early RA Promotes Inflammatory Pathways in Synovial Fibroblasts
Clare E Tange¹, Anna Engler¹, Christoph Kolling², Andrew Filer³, Christopher Buckley⁴, Beat A. Michel¹, Renate E. Gay¹, Steffen Gay¹ and Caroline Ospelt¹, ¹Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, ²Upper Extremity Dept., Schulthess Clinic Zurich, Zurich, Switzerland, ³University of Birmingham, Birmingham, United Kingdom, ⁴University of Birmingham, Rheumatology Research Group, Birmingham, United Kingdom
Background/Purpose: Synovial fibroblasts (SF) from the joints of RA patients display an activated and invasive phenotype. They produce a number of pro-inflammatory cytokines and proteolytic…