Abstracts tagged "Microparticles"

Abstract Number: 1916 • 2019 ACR/ARP Annual Meeting
Reduced DNASE1L3 Activity in Sporadic SLE Is Linked to Increased DNA Load of Microparticles, Reactivity to DNASE1L3-sensitive Antigens, and Lupus Nephritis
Johannes Hartl¹, Robert Clancy ¹, Peter Izmirly ¹, H Michael Belmont ², Catherine Trad ¹, Nicole Bornkamp ¹, Vanja Sisirak ¹, Benjamin Sally ¹, Jill Buyon ¹ and Boris Reizis ¹, ¹NYU School of Medicine, New York, ²NYU Langone Health, New York, NY
Background/Purpose: Null mutations in DNASE1L3 cause severe familial SLE with prominent anti-DNA antibodies (Abs), suggesting that DNASE1L3 is a key driver of tolerance to DNA.…
Abstract Number: 210 • 2015 ACR/ARHP Annual Meeting
Phenotypically Divergences of Monocyte Subsets and Microparticles in Systemic Lupus Erythematosus Patients
Catalina Burbano¹, Gloria Vásquez², Mauricio Rojas³ and Diana Castano⁴, ¹Corporación Ciencias Básicas Biomédicas, Grupo de Inmunología celular e Inmunogenética, Universidad de Antioquia. Medellín, Antioquia, Colombia., Medellin, Colombia, ²Rheumatology, Universidad de Antioquia, Medellin, Colombia, ³Unidad de Citometría de Flujo, Universidad de Antioquia. Medellín, Antioquia, Colombia., Medellin, Colombia, ⁴Grupo Inmunología Celular e Inmunogenética, Universidad de Antioquia, Medellín, Colombia
Background/Purpose: Mononuclear phagocytes depurate apoptotic cells, microparticles (MPs), and immune complexes (IC), leading to a tolerant or inflammatory microenvironment. The MPs, vesicular structures mainly produced…
Abstract Number: 1880 • 2015 ACR/ARHP Annual Meeting
Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases.
Eoghan M. McCarthy^1,2, Daniel Moreno-Martinez³, Fiona Wilkinson⁴, Neil J McHugh^5,6, Ian N. Bruce^7,8, Yvonne Alexander³, John D. Pauling^6,9 and Ben Parker^7,8, ¹The University of Manchester, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, Mmanchester, United Kingdom, ²NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospital NHS Foundation Trust, Manchester, United Kingdom, ³Healthcare Science Research Institute, Manchester Metropolitan University, Manchester, United Kingdom, ⁴School of Healthcare Science, Manchester Metropolitan University, Manchester, United Kingdom, ⁵Rheumatology, Bath Institute of Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, ⁶Department of Pharmacy and Pharmacology, University of Bath, Bath, United Kingdom, ⁷Central Manchester University Hospital NHS Foundation Trust and Manchester Academic Health Science Centre, NIHR Manchester Musculoskeletal Biomedical Research Unit, Manchester, United Kingdom, ⁸Stopford Building, Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, ⁹Upper Borough Walls, Royal National Hospital for Rheumatic Disease, Bath, United Kingdom
Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…
Abstract Number: 2575 • 2015 ACR/ARHP Annual Meeting
The Effect of mPGES-1 Deletion on Platelet Function in Mice
Joan Raouf¹, Fariborz Mobarrez², Karin Larsson¹, Per Johan Jakobsson¹ and Marina Korotkova¹, ¹Medicine, Department of Medicine, Rheumatology Unit, Karolinska University Hospital, Karolinska Institutet S-171 76, Stockholm, Sweden, Stockholm, Sweden, ²Department of Medicine, Karolinska Institutet, Rheumatology Unit, Karolinska University Hospital, Stockholm, Sweden
Background/Purpose: Microsomal prostaglandin E synthase-1 (mPGES-1) is an essential player in inflammation and has an indispensible role in the generation and maintenance of autoimmune disease…
Abstract Number: 23 • 2015 ACR/ARHP Annual Meeting
Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid
Nancy D. Kim¹, Robert B. Lochhead¹, Pauline Schmit², Minna J. Kohler³ and Andrew D. Luster⁴, ¹Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Charlestown, MA, ³Rheumatology, Allergy, and Immunology, Massachusetts General Hospital / Harvard Medical School, Boston, MA, ⁴Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…
Abstract Number: 2091 • 2014 ACR/ARHP Annual Meeting
Plasma Microparticle Protein Features Distinctively Classify Systemic Lupus Erythematosus and Systemic Sclerosis and Their Clinical Phenotype
Ole Østergaard¹, Christoffer T. Nielsen², Line V. Iversen³, Anders A. Bengtsson⁴, Søren Jacobsen⁵ and Niels H. H. Heegaard⁶, ¹Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institute, Copenhagen S, Denmark, ²Infectious Diseases and Rheumatology, University Hospital Rigshospitalet, Copenhagen, Denmark, ³Department of Clinical Biochemistry, Immunology & Genetics, Statens Serum Institut, Copenhagen, Denmark, ⁴Department of Clinical Sciences, Section of Rheumatology, Lund University, Lund, Sweden, ⁵Department of Rheumatology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark, ⁶Department of Clinical Biochemistry & Pharmacology, Odense University Hospital, Odense C, Denmark
Background/Purpose Plasma microparticles (MPs) comprise a heterogenous population of submicron membraneous vesicles shed from the cell-surface both constitutively and as a consequence of pathological processes.…
Abstract Number: 1049 • 2014 ACR/ARHP Annual Meeting
Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?
Bartijn C.H. Pieters, Onno J. Arntz, Mathijs G.A. Broeren, Arjan van Caam, Peter M. van der Kraan, Marieke de Vries and Fons A.J. van de Loo, Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands
Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…
Abstract Number: 2516 • 2013 ACR/ARHP Annual Meeting
Plasma Microparticles Are Associated With Venous Thrombosis In Systemic Lupus Erythematosus
Michelle Petri¹, Melissa Nastacio², Hong Fang¹, Thomas Kickler¹, Jayesh Jani¹ and Laurence S. Magder³, ¹Johns Hopkins University School of Medicine, Baltimore, MD, ²Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Epidemiology and Public Health, University of Maryland, Baltimore, MD
Background/Purpose: Thrombosis in SLE is highly associated with antiphospholipid antibodies, yet the majority of those with antiphospholipid antibodies never have a thrombotic event. Plasma microparticles…

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