Abstract Number: 1916 • ACR/ARP Annual Meeting 2019
Reduced DNASE1L3 Activity in Sporadic SLE Is Linked to Increased DNA Load of Microparticles, Reactivity to DNASE1L3-sensitive Antigens, and Lupus Nephritis
Background/Purpose: Null mutations in DNASE1L3 cause severe familial SLE with prominent anti-DNA antibodies (Abs), suggesting that DNASE1L3 is a key driver of tolerance to DNA.…Abstract Number: 23 • ACR/ARHP Annual Meeting 2015
Microvesicle-Associated Hsa-Mir-223-3p Is Elevated in Rheumatoid Synovial Fluid Compared with Osteoarthritis Synovial Fluid
Background/Purpose: Microvesicles (MVs) (100-1000 nm diameter) are subcellular particles that are enriched in nucleic acid, including microRNA (miR), which may be transferred from cell to…Abstract Number: 210 • ACR/ARHP Annual Meeting 2015
Phenotypically Divergences of Monocyte Subsets and Microparticles in Systemic Lupus Erythematosus Patients
Background/Purpose: Mononuclear phagocytes depurate apoptotic cells, microparticles (MPs), and immune complexes (IC), leading to a tolerant or inflammatory microenvironment. The MPs, vesicular structures mainly produced…Abstract Number: 1880 • ACR/ARHP Annual Meeting 2015
Circulating Microparticle Populations May Differentiate Between Connective Tissue Diseases.
Background/Purpose: Microparticles (MPs) are membrane-bound vesicles derived from vascular and intravascular cells such as endothelial cells (EMPs) and platelets (PMPs). Circulating MPs levels are altered…Abstract Number: 2575 • ACR/ARHP Annual Meeting 2015
The Effect of mPGES-1 Deletion on Platelet Function in Mice
Background/Purpose: Microsomal prostaglandin E synthase-1 (mPGES-1) is an essential player in inflammation and has an indispensible role in the generation and maintenance of autoimmune disease…Abstract Number: 2091 • ACR/ARHP Annual Meeting 2014
Plasma Microparticle Protein Features Distinctively Classify Systemic Lupus Erythematosus and Systemic Sclerosis and Their Clinical Phenotype
Background/Purpose Plasma microparticles (MPs) comprise a heterogenous population of submicron membraneous vesicles shed from the cell-surface both constitutively and as a consequence of pathological processes.…Abstract Number: 1049 • ACR/ARHP Annual Meeting 2014
Bioactive TGF-β Is Present on Bovine Milk-Derived Exosomes: Consequences for Patients?
Background/Purpose: Development of rheumatoid arthritis (RA) is associated with different genetic and environmental factors. We postulate that cow milk could be such an environmental trigger…Abstract Number: 2516 • ACR/ARHP Annual Meeting 2013
Plasma Microparticles Are Associated With Venous Thrombosis In Systemic Lupus Erythematosus
Background/Purpose: Thrombosis in SLE is highly associated with antiphospholipid antibodies, yet the majority of those with antiphospholipid antibodies never have a thrombotic event. Plasma microparticles…
ACR Meeting Abstracts