Abstracts tagged "microparticles and pharmacotherapy"

Abstract Number: 2900 • 2017 ACR/ARHP Annual Meeting
Osteoarthritis-Associated Calcium-Containing Crystals and Biomaterial Microparticles Both Drive M1 Macrophage Polarization in a Syk and MAP Kinase-Dependent Manner
Geraldine M. McCarthy¹, Olwyn Mahon², Sarah O'Hanlon³, Daniel Kelly⁴ and Aisling Dunne⁵, ¹Div of Rheumatology, Mater Misericordiae University Hospital, Dublin, Ireland, ²School of Biochemistry and Immunology,, ,Trinity College Dublin, Dublin, Ireland, ³School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland, ⁴Trinity Center for Bioengineering, ,Trinity College Dublin, Dublin, Ireland, ⁵School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Background/Purpose: Intra-articular basic calcium phosphate (BCP) crystals are associated with advanced osteoarthritis (OA) andsynovitis. OA-associated synovium exhibits increased numbers of macrophages compared with non-OA joints.…

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Abstracts tagged "microparticles and pharmacotherapy"

Osteoarthritis-Associated Calcium-Containing Crystals and Biomaterial Microparticles Both Drive M1 Macrophage Polarization in a Syk and MAP Kinase-Dependent Manner