Abstracts tagged "microbiome and transcription factor"

Abstract Number: 2695 • ACR/ARHP Annual Meeting 2016
Genetic Association of Ankylosing Spondylitis with TBX21 Influences T-Bet and Pro-Inflammatory Cytokine Expression in Humans and SKG Mice As a Model of Spondyloarthritis and Alters Host Microbiome and Response to Microbial Stimuli
Max Lau¹, Patricia Keith¹, Madeline McCready¹, Mary-Ellen Costello¹, Linda Bradbury¹, Kelly Holiis¹, Ranjeny Thomas², Gethin P. Thomas³, Matthew A. Brown¹ and Tony J. Kenna¹, ¹Translational Research Institute, Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia, ²Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ³Translational Reserch Institute, The University of Queensland Diamantina Institute, Brisbane, Australia
Background/Purpose: TBX21 encodes the transcription factor T-bet and is genome-wide significant associated with ankylosing spondylitis (AS). T-bet is implicated in innate and adaptive immunity. However,…