Abstracts tagged "microbiome and spondylarthropathy"

Abstract Number: 2829 • 2018 ACR/ARHP Annual Meeting
The Response to TNF-Blockers Treatment of Spa Patients Is Influenced By the Interplay between HLA-B27 and Gut Microbiota Composition at Baseline
Marie Vallier¹, Maxime Dougados², Stephanie Ferreira³, Silvia Menegatti⁴, Elisabetta Bianchi⁵, Lars Rogge⁵, Mathias Chamaillard¹ and Corinne Miceli-Richard², ¹CIIL - U1019 - NLRII, Institut Pasteur, Lille, France, ²Rheumatology Department, Paris Descartes University, Paris, France, ³Genoscreen, Lille, France, ⁴Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, ⁵Immunology, Institut Pasteur, Paris, France
Background/Purpose: The response to TNF-blockers in axial spondyloarthritis (AxSpA) is at least partially influenced by HLA-B27 through a still poorly understood mechanism. Given that HLA-B27…
Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting
Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background
Tejpal Gill¹, Mark Asquith², Stephen Brooks³, James T. Rosenbaum² and Robert A. Colbert¹, ¹National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, ²Oregon Health & Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD
Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting
HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint
Mark Asquith¹, Sean Davin¹, Patrick Stauffer¹, Claire Mitchell² and James T. Rosenbaum¹, ¹Oregon Health & Science University, Portland, OR, ²Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR
Background/Purpose: HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
Abstract Number: 2097 • 2015 ACR/ARHP Annual Meeting
HLA-B27 Expression Profoundly Shapes the Host-Microbiota Metabolome
Mark Asquith¹, Patrick Stauffer², Sean Davin³, Stephen R. Planck⁴, Phoebe Lin⁵ and James T. Rosenbaum⁶, ¹OHSU, Portland, OR, ²Oregon Health & Science University, Portland, OR, ³Oregon Health and Science University, Portland, OR, ⁴Casey Eye Institute, Oregon Health & Science University, Portland, OR, ⁵Casey Eye Institute, Oregon Health and Science University, Portland, OR, ⁶Devers Eye Institute, Legacy Hospital system, Portland, OR
Background/Purpose: The intestinal microbiota plays a pivotal role in both host fitness and disease. Increasing evidence implicates microbial metabolites in the modulation of host immunity…
Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting
HLA-B27 Expression Shapes the Intestinal Microbiota
Mark Asquith¹, Phoebe Lin², Tejpal Gill³, Justine Debelius⁴, Patrick Stauffer⁵, Sean Davin⁵, Gail Ackermann⁴, Robert A. Colbert³, Rob Knight⁴ and James Rosenbaum^1,6, ¹Division of Rheumatology, Oregon Health and Science University, Portland, OR, ²Casey Eye Institute, Oregon Health and Science University, Portland, OR, ³NIAMS/NIH, Bethesda, MD, ⁴University of Colorado Boulder, Boulder, CO, ⁵Oregon Health and Science University, Portland, OR, ⁶Dever's Eye Institute, Legacy Hospital, Portland, OR
Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…
Abstract Number: 2695 • 2013 ACR/ARHP Annual Meeting
Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger
Linda Rehaume¹, Stanislas Mondot², Daniel Aguirre de Cárcer², Jared Velasco¹, Helen Benham¹, Sumaira Hasnain³, Jaclyn Bowman¹, Merja Ruutu¹, Philip Hansbro⁴, Michael McGuckin³, Mark Morrison² and Ranjeny Thomas¹, ¹University of Queensland Diamantina Institute, Brisbane, Australia, ²CSIRO Livestock Industries, Brisbane, Australia, ³Mater Medical Research Institute, Brisbane, Australia, ⁴Center for Asthma and Respiratory Disease and Hunter Medical Research Institute, Newcastle, Australia
Background/Purpose: Chronic inflammatory diseases known as spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and arthritis associated with inflammatory bowel disease, collectively affect 3%…

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