ACR Meeting Abstracts

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Abstracts tagged "microbiome and spondylarthropathy"

  • Abstract Number: 2829 • 2018 ACR/ARHP Annual Meeting

    The Response to TNF-Blockers Treatment of Spa Patients Is Influenced By the Interplay between HLA-B27 and Gut Microbiota Composition at Baseline

    Marie Vallier1, Maxime Dougados2, Stephanie Ferreira3, Silvia Menegatti4, Elisabetta Bianchi5, Lars Rogge5, Mathias Chamaillard1 and Corinne Miceli-Richard2, 1CIIL - U1019 - NLRII, Institut Pasteur, Lille, France, 2Rheumatology Department, Paris Descartes University, Paris, France, 3Genoscreen, Lille, France, 4Immunology, Immunoregulation Unit, Institut Pasteur, Paris, France, 5Immunology, Institut Pasteur, Paris, France

    Background/Purpose: The response to TNF-blockers in axial spondyloarthritis (AxSpA) is at least partially influenced by HLA-B27 through a still poorly understood mechanism. Given that HLA-B27…
  • Abstract Number: 3165 • 2016 ACR/ARHP Annual Meeting

    HLA-B27 Expression Is Accompanied By a Profoundly Altered IgA Response to the Intestinal Microbiota and Microbial Translocation to the Joint

    Mark Asquith1, Sean Davin1, Patrick Stauffer1, Claire Mitchell2 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Division of Arthritis and Rheumatology, Oregon Health & Science University, Portland, OR

    Background/Purpose:  HLA-B27 is the strongest known genetic risk factor for ankylosing spondylitis and other spondyloarthropathies (SpAs). We have shown previously that Fisher 344 rats that…
  • Abstract Number: 3164 • 2016 ACR/ARHP Annual Meeting

    Spondyloarthritis Pathogenesis Involves Interplay Between Gut Microbiota and Genetic Background

    Tejpal Gill1, Mark Asquith2, Stephen Brooks3, James T. Rosenbaum2 and Robert A. Colbert1, 1National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD, 2Oregon Health & Science University, Portland, OR, 3NIAMS/NIH, Bethesda, MD

    Background/Purpose: HLA-B27 and human b2m expression in rats induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA). While aspects of rat SpA have been studied…
  • Abstract Number: 2097 • 2015 ACR/ARHP Annual Meeting

    HLA-B27 Expression Profoundly Shapes the Host-Microbiota Metabolome

    Mark Asquith1, Patrick Stauffer2, Sean Davin3, Stephen R. Planck4, Phoebe Lin5 and James T. Rosenbaum6, 1OHSU, Portland, OR, 2Oregon Health & Science University, Portland, OR, 3Oregon Health and Science University, Portland, OR, 4Casey Eye Institute, Oregon Health & Science University, Portland, OR, 5Casey Eye Institute, Oregon Health and Science University, Portland, OR, 6Devers Eye Institute, Legacy Hospital system, Portland, OR

    Background/Purpose: The intestinal microbiota plays a pivotal role in both host fitness and disease. Increasing evidence implicates microbial metabolites in the modulation of host immunity…
  • Abstract Number: 1919 • 2014 ACR/ARHP Annual Meeting

    HLA-B27 Expression Shapes the Intestinal Microbiota

    Mark Asquith1, Phoebe Lin2, Tejpal Gill3, Justine Debelius4, Patrick Stauffer5, Sean Davin5, Gail Ackermann4, Robert A. Colbert3, Rob Knight4 and James Rosenbaum1,6, 1Division of Rheumatology, Oregon Health and Science University, Portland, OR, 2Casey Eye Institute, Oregon Health and Science University, Portland, OR, 3NIAMS/NIH, Bethesda, MD, 4University of Colorado Boulder, Boulder, CO, 5Oregon Health and Science University, Portland, OR, 6Dever's Eye Institute, Legacy Hospital, Portland, OR

    Background/Purpose The intestinal microbiota plays a central role in both health and disease. Beyond shaping local immune responses in the gut, it is increasingly clear…
  • Abstract Number: 2695 • 2013 ACR/ARHP Annual Meeting

    Host Genetic Background Disrupts The Relationship Between Microbiota and Gut Mucosal Tolerance Leading To Spondyloarthritis and Ileitis After a Dectin-1 Trigger

    Linda Rehaume1, Stanislas Mondot2, Daniel Aguirre de Cárcer2, Jared Velasco1, Helen Benham1, Sumaira Hasnain3, Jaclyn Bowman1, Merja Ruutu1, Philip Hansbro4, Michael McGuckin3, Mark Morrison2 and Ranjeny Thomas1, 1University of Queensland Diamantina Institute, Brisbane, Australia, 2CSIRO Livestock Industries, Brisbane, Australia, 3Mater Medical Research Institute, Brisbane, Australia, 4Center for Asthma and Respiratory Disease and Hunter Medical Research Institute, Newcastle, Australia

    Background/Purpose: Chronic inflammatory diseases known as spondyloarthropathies (SpA) including ankylosing spondylitis, psoriatic arthritis, reactive arthritis, and arthritis associated with inflammatory bowel disease, collectively affect 3%…
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