Abstracts tagged "microbiome and spondylarthritis"

Abstract Number: 1828 • 2018 ACR/ARHP Annual Meeting
Gut-Joint T Cell Trafficking in a Model of Bacteria-Driven Murine IBD-Spa
Eric Norman¹, Adam Lefferts¹ and Kristine A Kuhn^1,2, ¹Rheumatology, University of Colorado Denver, Aurora, CO, ²Mucosal Inflammation Program, University of Colorado Denver, Aurora, CO
Background/Purpose: Significant bacterial dysbiosis occurs in individuals with IBD and SpA, and individuals with SpA have evidence of circulating intestinal-derived cells, lending credence to the…
Abstract Number: 641 • 2017 ACR/ARHP Annual Meeting
Children with Treatment-Naive Enthesitis-Related Arthritis Have Decreased Fecal Abundance of Faecalibacterium Prausnitzii A2-165 and Bacteroides Fragilis: A Multi-Center Collaborative Study
Matthew L. Stoll¹, Pamela F. Weiss², Jennifer E. Weiss³, Peter Nigrovic⁴, Barbara Edelheit⁵, S. Louis Bridges Jr.⁶, Maria I. Danila⁷, Charles Spencer⁸, Marilynn Punaro⁹, Kenneth Schikler¹⁰, Andreas Reiff¹¹, Ranjit Kumar¹², Randy Q. Cron¹, Casey D Morrow¹³ and Elliot J. Lefkowitz¹⁴, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Division of Rheumatology, Center for Pediatric Clincial Effectiveness, Children's Hospital of Philadelphia, Philadelphia, PA, ³Hackensack University Medical Center, Hackensack, NJ, ⁴Division of Rheumatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁵Pediatric Rheumatology, Connecticut Childrens Medical Center, Hartford, CT, ⁶Clinical Immunology & Rheum, Univ of Alabama, Birmingham, AL, ⁷University of Alabama at Birmingham, Birmingham, AL, ⁸Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ⁹Children's Health, Dallas, TX, ¹⁰University of Louisville Medical School, Louisville, KY, ¹¹Children’s Hospital of Los Angeles, Los Angeles, CA, ¹²Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ¹³Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ¹⁴Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Prior studies have demonstrated abnormalities in the composition of the gastrointestinal microbiota in pediatric and adult patients with spondyloarthritis (SpA.) In particular, diminished fecal…
Abstract Number: 2710 • 2016 ACR/ARHP Annual Meeting
Bacterial Dysbiosis Associates with Functional Intraepithelial Lymphocyte Changes in Inflammatory Bowel Disease and Spondyloarthritis
Neha Ohri^1,2,3, Mark Gerich^3,4, Blair Fennimore^3,5, Diana Ir⁶, Charles Robertson⁶, Daniel Frank⁶, Liron Caplan⁷, Brandie Wagner⁸ and Kristine Kuhn^9,10, ¹Division of Rheumatology, Mount Sinai West, New York City, NY, ²Division of Rheumatology, University of Colorado, Aurora, CO, ³Mucosal Inflammation Program, University of Colorado, Aurora, CO, ⁴Division of Gastroenterology, University of Colorado, Aurora, CO, ⁵Department of Gastroenterology, University of Colorado, Aurora, CO, ⁶Division of Infectious Disease, University of Colorado, Aurora, CO, ⁷Denver Veterans Affairs Medical Center and UC Denver SOM, Denver, CO, ⁸Department of Biostatistics and Informatics, University of Colorado, Aurora, CO, ⁹Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ¹⁰Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO
Background/Purpose: The microbiome is hypothesized to influence human health and disease. Changes in resident bacteria, termed dysbiosis, occur in spondyloarthritis (SpA) and inflammatory bowel disease…
Abstract Number: 2805 • 2015 ACR/ARHP Annual Meeting
Enteric Flora in Newly Diagnosed Spondyloarthritis: A Collaborative Study
Matthew L. Stoll¹, Pamela F. Weiss², Jennifer E. Weiss³, Peter A. Nigrovic⁴, Marilynn G. Punaro⁵, Charles H. Spencer⁶, Kenneth N. Schikler⁷, Casey D Morrow⁸ and Elliot J. Lefkowitz⁹, ¹University of Alabama at Birmingham, Birmingham, AL, ²Rheumatology, Children's Hospital of Philadelphia, Philadelphia, PA, ³Hackensack Univ Med Ctr, Hackensack, NJ, ⁴Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, ⁵Texas Scottish Rite Hospital, Dallas, TX, ⁶Rheumatology, Nationwide Childrens Hospital/OSU, Columbus, OH, ⁷Pediatrics, University of Louisville, Louisville, KY, ⁸Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁹Microbiology, University of Alabama at Birmingham, Birmingham, AL
Matthew L Stoll, Pamela F Weiss, Jennifer E Weiss, Peter A Nigrovic, Lynn Punaro, Charles Spencer, Ken Schikler, Casey Morrow, Elliot Lefkowitz Enteric flora in…
Abstract Number: 2820 • 2015 ACR/ARHP Annual Meeting
Multi-Omics Studies of Gut Microbiota in Enthesitis-Related Arthritis Identify Diminished Microbial Diversity and Altered Typtophan Metabolism As Potential Factors in Disease Pathogenesis
Matthew L. Stoll¹, Landon S. Wilson², Stephen Barnes³, Ranjit Kumar⁴, Anna Genin⁵, Randy Q. Cron¹, Charles O. Elson⁶, Casey D Morrow⁷ and Elliot J. Lefkowitz⁸, ¹Pediatric Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ²Pharmicology / Toxicology, University of Alabama at Birmingham, Birmingham, AL, ³Pharmicology, University of Alabama at Birmingham, Birmingham, AL, ⁴Center for Clinical and Translational Sciences, University of Alabama at Birmingham, Birmingham, AL, ⁵Pediatrics, University of Alabama at Birmingham, Birmingham, AL, ⁶Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁷Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, ⁸Microbiology, University of Alabama at Birmingham, Birmingham, AL
Background/Purpose: Children with enthesitis-related arthritis (ERA) and adults with spondyloarthritis are at risk for intestinal inflammation. We have previously shown altered microbiota in children with…
Abstract Number: 2827 • 2015 ACR/ARHP Annual Meeting
Analysis of HLA-B27 Transgenic Rats Reveals Specific Gut Transcriptome and Microbiome Signatures Associated with Inflammation
Tejpal Gill¹, Mark Asquith², Stephen Brooks¹, James T. Rosenbaum³ and Robert A. Colbert⁴, ¹NIAMS/NIH, Bethesda, MD, ²OHSU, Portland, OR, ³Devers Eye Institute, Legacy Hospital system, Portland, OR, ⁴National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD
Background/Purpose: HLA-B27 and human beta 2-microglobulin expression in rats (transgenic; TG) induces a spontaneous inflammatory disease resembling human spondyloarthritis (SpA) with associated gastrointestinal inflammation. While…
Abstract Number: 2828 • 2015 ACR/ARHP Annual Meeting
Profiling Immunogenic Bacteria within the Microbiota of ZAP-70 Mutant SKG Mice Associated with Spondyloarthritis and Ileitis Using IgA-SEQ
Linda Rehaume¹, Alicia Kang¹, Olga Zbarskaya¹, Jane Mullaney¹, Matthew Kim¹, Paraic O Cuiv¹, Nicola Angel², Philip Hugenholtz², Mark Morrison¹ and Ranjeny Thomas¹, ¹Translational Research Institute, The University of Queensland Diamantina Institute, Brisbane, Australia, ²Australian Centre for Ecogenomics, The University of Queensland, Brisbane, Australia
Background/Purpose: IgA production is the main barrier mechanism of mucosal surfaces. High affinity IgA is generated through T cell-dependent mechanisms and preferentially binds to invasive…
Abstract Number: 2496 • 2013 ACR/ARHP Annual Meeting
HLA-B27 Influence On The Gut Microbiome
Robert D. Inman¹, Aifeng Lin², Phillip Sherman³ and Lee Pinnell⁴, ¹Dept of Medicine/Rheumatology, Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, Canada, ²Medicine/Rheumatology, Toronto Western Research Institute and University Health Network, Toronto, ON, Canada, ³Pediatrics, Hospital for Sick Children, Toronto, ON, Canada, ⁴Hospital for Sick Children, Toronto, ON, Canada
Background/Purpose: The interrelationship between the gut microbiome and spondyloarthritis (SpA) has been highlighted by recent findings of (i) Subclinical bowel inflammation in SpA (ii) Antimicrobial…

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