Abstracts tagged "Microbiome and rheumatoid arthritis"

Abstract Number: 54 • 2019 ACR/ARP Annual Meeting
A Metagenome-wide Association Study of Gut Microbiome Revealed Novel Etiology of Rheumatoid Arthritis in the Japanese Population
Toshihiro Kishikawa ¹, Yuichi Maeda ², Takuro Nii ¹, Daisuke Motooka ¹, Yuki Matsumoto ¹, Masato Matsushita ³, Hidetoshi Matsuoka ⁴, Maiko Yoshimura ⁴, Shoji Kawada ⁵, Satoru Teshigawara ⁴, Eri Oguro ¹, Yasutaka Okita ⁴, Keisuke Kawamoto ⁵, Shinji Higa ⁶, Toru Hirano ⁷, Masashi Narazaki ¹, Atsushi Ogata ⁵, Yukihiko Saeki ⁸, Shota Nakamura ¹, Hidenori Inohara ¹, Atsushi Kumanogoh ¹, Kiyoshi Takeda ¹ and Yukinori Okada¹, ¹Osaka University, Suita, Japan, ²Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan, ³Saiseikai Senri Hospital, Suita, Japan, ⁴NHO Osaka Minami Medical Center, Kawachinagano, Japan, ⁵Daini Osaka Police Hospital, Tennoji-ku, Japan, ⁶Osaka Second Police Hospital, Osaka, Japan, ⁷Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Osaka, Japan, ⁸NHO Osaka Minami Medical Center, Kawachinagano, Osaka, Japan
Background/Purpose: The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed…
Abstract Number: 34 • 2018 ACR/ARHP Annual Meeting
Microbiome-Drived Aberration of Hematopoietic Stem Cell Development Facilitates Immune Deregulation on the Onset of Collagen-Induced Arthritis in Mice
Peiqing Yang¹, Lingchong Su¹, Yanhong Li¹, Yi Liu² and Yubin Luo³, ¹West China Hospital, Sichuan University, Chengdu, China, ²Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan, China, Chengdu, China, ³Department of Rheumatology & Immunology,, West China Hosptial, Sichuan University, Chengdu, China
Background/Purpose: Increasing studies indicate that immune deregulation occurs prior to symptom in Rheumatoid arthritis (RA). Hematopoietic stem cell (HSC) gives rise to multipotent progenitors differentiating…
Abstract Number: 2562 • 2016 ACR/ARHP Annual Meeting
Human Seroreactivity to Gut Microbiota Antigens in Rheumatoid Arthritis and Controls-Lack of Association with Rheumatoid Arthritis Autoantibodies
Carol Hitchon¹, Charles O. Elson², David Robinson³, Irene Smolik³ and Hani S. El-Gabalawy¹, ¹University of Manitoba, Winnipeg, MB, Canada, ²Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, ³Arthritis Center, University of Manitoba, Winnipeg, MB, Canada
Background/Purpose: The human gut microbiome maintains normal immune homeostasis. Changes to the microbiota evolve with aging and have been implicated in the development of autoimmune…

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