ACR Meeting Abstracts

ACR Meeting Abstracts

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Abstracts tagged "microbiome and mouse model"

  • Abstract Number: 1915 • 2016 ACR/ARHP Annual Meeting

    Partial Elimination of Intestinal Microbiota Dampens T Helper 17 Cell Differentiation and Established Collagen-Induced Arthritis in Mice

    Rebecca Rogier1, Heather Evans-Marin2, Birgitte Walgreen1, Monique M. Helsen1, Liduine van den Bersselaar1, Peter M. van der Kraan1, Fons A.J. van de Loo3, Peter L. van Lent1, Jose U. Scher4, Wim B. van den Berg1, Marije I. Koenders1 and Shahla Abdolahi-Roodsaz1, 1Experimental Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 2Division of Rheumatology, New York University School of Medicine, New York, NY, 3Rheumatology, Radboud university medical center, Nijmegen, Netherlands, 4New York University School of Medicine, New York, NY

    Background/Purpose: High-throughput sequencing of intestinal microbiota recently revealed that the composition of intestinal microbiota is perturbed in patients with new onset untreated rheumatoid arthritis (RA).…
  • Abstract Number: 1762 • 2015 ACR/ARHP Annual Meeting

    Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model

    Toshiki Eri1, Kimito Kawahata2, Ei Bannai1, Takeyuki Kanzaki3, Lisa Akahira1, Kazuya Michishita1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan

    Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
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