Abstracts tagged "microbiome and molecular mimicry"

Abstract Number: 920 • 2016 ACR/ARHP Annual Meeting
Autoantigen-Specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome
William Ruff¹, Carina Dehner², Alex Roth¹, Silvio M. Vieira¹, Cassyanne L. Aguiar^3,4, Andrew Goodman⁵, Doruk Erkan⁶ and Martin Kriegel¹, ¹Immunobiology, Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, new haven, CT, ³Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, ⁴Cohen Children's Medical Center of New York/ Hofstra Northwell School of Medicine, Pediatric Rheumatology, New York, NY, ⁵Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, ⁶Rheumatology, Hospital for Special Surgery- Weill Cornell Medicine, New York, NY
Autoantigen-specific T Cell and Antibody Reactivity to a Human Gut Commensal in Antiphospholipid Syndrome William Ruff1, Carina Dehner1, Alex Roth1, Silvio M. Vieira1, Cassyanne L.…
Abstract Number: 1834 • 2016 ACR/ARHP Annual Meeting
Commensal Ro60 Autoantigen Ortholog Cross-Reactivity in Human Lupus and Gnotobiotic Models
Teri Greiling¹, Carina Dehner², Stephen Renfroe³, Xinguo Chen⁴, Kevin Hughes⁴, Silvio M. Vieira³, William Ruff³, Marco Boccitto⁴, Andrew Goodman⁵, Sandra L. Wolin⁴ and Martin Kriegel^3,6, ¹Dermatology and Immunobiology, Yale School of Medicine, New Haven, CT, ²Immunobiology, Yale School of Medicine, new haven, CT, ³Immunobiology, Yale School of Medicine, New Haven, CT, ⁴Cell Biology, Yale School of Medicine, New Haven, CT, ⁵Microbial Pathogenesis, Yale School of Medicine, New Haven, CT, ⁶Medicine/Division of Rheumatology, Yale School of Medicine, New Haven, CT
Background/Purpose: The earliest autoantibodies in lupus are directed against the autoantigen Ro60, an RNA binding protein with orthologs that we identified in a subset of…

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