ACR Meeting Abstracts

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Abstracts tagged "Micro-RNA"

  • Abstract Number: 0075 • ACR Convergence 2024

    Micro-RNAs as Biomarkers for Methotrexate Treatment Response in Patients with Psoriatic Arthritis

    Darshini Ganatra1, Omar Cruz Correa1, Ameth Garrido2, Starlee Lively3, Rohan Apurva Machhar4, Remy Pollock5, Mohit Kapoor6 and Dafna Gladman7, 1University Health Network, Toronto, ON, Canada, 2University of Toronto, Toronto, ON, Canada, 3UHN, Toronto, Canada, 4Novartis, Mississauga, ON, Canada, 5Pfizer, Toronto, ON, Canada, 6Schroeder Arthritis Institute, University Health Network, Toronto, ON, Canada, 7University of Toronto, Toronto Western Hospital, Toronto, ON, Canada

    Background/Purpose: Psoriatic arthritis (PsA) is a form of inflammatory arthritis linked to psoriasis, a chronic skin and nail disease. PsA is a progressive joint disease…
  • Abstract Number: 1202 • ACR Convergence 2024

    Harnessing MicroRNA and Machine/Deep Learning for Early Prediction of Knee Osteoarthritis Structural Progression

    Afshin Jamshidi1, Osvaldo Espin-Garcia2, Thomas G. Wilson3, Ian Loveless3, Jean-Pierre Pelletier1, Amanda Ali4 and Johanne Martel-Pelletier1, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, 2Department of Epidemiology and Biostatistics, University of Western Ontario; Dalla Lana School of Public Health and Department of Statistical Sciences, University of Toronto; Department of Biostatistics, Schroeder Arthritis Institute; Krembil Research Institute, University Health Network, Toronto, ON, Canada, 3Henry Ford Health + Michigan State University Health Sciences, Detroit, MI, 4Henry Ford Health + Michigan State University Health Sciences; Center for Molecular Medicine and Genetics, Wayne State University, Montreal, QC, Canada

    Background/Purpose: The development of knee osteoarthritis (OA) is generally characterized by a slow evolution. However, its progression and severity may occur rapidly in some individuals.…
  • Abstract Number: 1654 • ACR Convergence 2024

    CRTAC1 in Osteoarthritis: Implications for Disease Severity and miRNA Regulation

    Aneta Prokopcová1, Jiri Baloun2, Adéla Navrátilová3, Klára Mocová2, Lucia Ondrejčáková4, Jana Juhaszova2, Tereza Kropáčková1, Hana Storkanova5, Michal Tomcik5, Jindriska Gatterova2, Olga Sleglova2, Olga Ruzickova2, Eva Kriegova6, Jiri Gallo7, Rastislav Ballay8, Petr Fulin9, Jiří Vencovský1 and Ladislav Šenolt1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 31st Faculty of Medicine, Charles University and Institute of Rheumatology in Prague, Hlavní mesto Praha, Czech Republic, 4Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, 5Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department of Immunology, Faculty of Medicine and Dentistry, Palacky University and University Hospital, Olomouc, Czechia, Olomouc, Czech Republic, 7Department of Orthopaedics, University Hospital Olomouc, Olomouc, Czech Republic, 81st Faculty of Medicine, Charles University, Prague, Czechia, Prague, Czech Republic, 91st Department of Orthopaedics, First Faculty of Medicine of Charles University and Motol University Hospital, Prague, Czechia, Prague, Czech Republic

    Background/Purpose: Cartilage acidic protein1 (CRTAC1) is a potential biomarker linked to osteoarthritis (OA) and cartilage degeneration. This study aimed to compare CRTAC1 levels in the…
  • Abstract Number: 1711 • ACR Convergence 2024

    Identification of Psoriatic Arthritis-related Pathways Using Multi-omics Data Integration

    Sreemoyee Ghosh1, Chiara Pastrello2, Omar F. Cruz-Correa3, Darshini Ganatra4, Katerina Oikonomopoulou3, Melanie Anderson5, Igor Jurisica6 and Vinod Chandran7, 1Institute of Medical Science, University of Toronto and Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Osteoarthritis Research Program, Division of Orthopaedic Surgery, Schroeder Arthritis Institute and Data Science Discovery Centre for Chronic diseases, Krembil Research Institute, Toronto, ON, Canada, 3Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 4University Health Network, Toronto, ON, Canada, 5The Institute for Education Research, Library and Information Services, University Health Network, Toronto, ON, Canada, 6Departments of Medical Biophysics and Computer Science and Faculty of Dentistry, University of Toronto and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia, Toronto, ON, Canada, 7University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriasis (Pso) is a chronic immune mediated inflammatory skin disease. Up to 24% of Pso patients develop psoriatic arthritis (PsA). Pathophysiology of PsA is…
  • Abstract Number: 2293 • ACR Convergence 2024

    Altered Expression of the MicroRNA Biogenesis Machinery Components Correlates with Inflammatory Parameters in Salivary Glands of Patient with Sjögren’s Disease

    Sergio Aguilera1, Patricia Carvajal2, Isabel Castro2, María-José Barrera3, Sergio González4, Claudio Molina3 and María-Julieta González2, 1Clinica Indisa, Santiago, Chile, 2Universidad de Chile, Santiago, Chile, 3Universidad San Sebastián, Santiago, Chile, 4Universidad Mayor, Santiago, Chile

    Background/Purpose: MicroRNAs (miRNAs) are small non-coding RNAs involved in the regulation of gene expression at the post-transcriptional level (by translational blocking or mRNA degradation). The…
  • Abstract Number: 0960 • ACR Convergence 2023

    MiR-3606-3p Alleviates Skin Fibrosis by Suppressing Fibroblast Inflammation and Migration via Inhibiting GAB1 and ITGAV

    yahui chen1, Mengkun shi1, Wei Wang1, Chenyi Shi1, Xueyi Xia1, wenyu Wu2, Jiucun Wang3 and Xiangguang Shi3, 1Fudan University, Shanghai, China, 2Huashan Hospital, Shanghai, China, 3Shanghai, Shanghai, China

    Background/Purpose: Systemic sclerosis (SSc) and keloid are typical skin fibrotic diseases with unclear epigenetic mechanisms and clinical targets. As an important epigenetic regulatory factor, microRNAs…
  • Abstract Number: 1266 • ACR Convergence 2023

    The Anti-inflammatory Effect of High-density Lipoprotein Is Blunted by Delivery of Altered MicroRNA Cargo to Macrophages in Patients with Rheumatoid Arthritis

    Qiong Wu, Quanhu Sheng, Danielle Michell, Marisol Ramirez-Solano, Olivia Posey, Anastasiia Phothisane, Shahensha Shaik, Kasey Vickers and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: High-density lipoprotein (HDL) has well-characterized anti-atherogenic cholesterol efflux and antioxidant functions. Another function of HDL uncharacterized in RA is its ability to transport microRNAs…
  • Abstract Number: 1752 • ACR Convergence 2023

    Fibroblast Expression of Neurotransmitter Receptor HTR2A Associates with Inflammation in Rheumatoid Arthritis Joint

    Chunyan Xiang1, Soomin Hong1, Bingjiao Zhao2, Hui Pi3, Fang Du4, Xingyu Lu5, Yuanjia Tang1, Nan Shen6, Chunxi Yang7 and Runci Wang8, 1Shanghai Institute of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 2Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, China, 3Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China, 4Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 5Department of Endocrinology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, 6Shanghai Jiao Tong University School of Medicine, Shanghai, China, 7Department of Orthopedics, Renji Hospital, School of Medicine, Shanghai Jiao Tong University (SJTUSM), Shanghai, China, 8Renji hospital, Shanghai Jiaotong University, Pudong Xinqu, China

    Background/Purpose: Peripheral neuroimmune crosstalk plays a crucial role in the inflammatory process and bone metabolism in joint. Serotonin receptor HTR2A was reported to be expressed…
  • Abstract Number: 1792 • ACR Convergence 2023

    Identifying Synovial Fluid Micro-RNA Signature That Distinguishes Psoriatic Arthritis from Osteoarthritis

    Darshini Ganatra1, Anas Samman1, David Nasri1, Sara Rahmati1, Omar Cruz Correa1, Rohan Machhar1, Rajiv Gandhi2, Mohit Kapoor3 and Vinod Chandran4, 1Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, ON, Canada, 2Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada, 3Schroeder Arthritis Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, ON, Canada, 4Schroeder Arthritis Institute, Krembil Research Institute, University Health Network and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto, ON, Canada

    Background/Purpose: Psoriatic Arthritis (PsA) is an inflammatory arthritis and shares several clinical features with Osteoarthritis (OA), the most common form of arthritis. This often leads…
  • Abstract Number: 2135 • ACR Convergence 2023

    Synovial Fluid High-density Lipoprotein (HDL)-miR-1246 Is Enriched in Patients with Inflammatory Arthritis Compared to Osteoarthritis and Increases Synovial Fibroblast IL-6 Expression

    Olivia Posey1, Qiong Wu1, Anastasiia Phothisane1, Christine Pham2, Deborah Parks2, Antonina Akk3, Danielle Michell1, Kasey Vickers1 and Michelle Ormseth1, 1Vanderbilt University Medical Center, Nashville, TN, 2Washington University, St. Louis, MO, 3Washington University in St. Louis, St. Louis, MO

    Background/Purpose: High-density lipoprotein (HDL), known for its anti-atherogenic reverse cholesterol transport function, also transports miRNAs between cells, altering cellular function. We found that compared to…
  • Abstract Number: 0398 • ACR Convergence 2023

    Identification of Disease Activity-related miRNAs Through Artificial Neural Network Analysis in Rheumatoid Arthritis

    Milena Rodriguez Alvarez1, Lissette Delgado-Cruzata2, Anna Tryfonos1, Nickolas Almodovar2, Toni-Ann Bravo2 and Naureen Kabani1, 1SUNY Downstate Health Sciences University, Brooklyn, NY, 2The City University of New York, John Jay College, New York, NY

    Background/Purpose: Rheumatoid Arthritis (RA) is the result of the complex interplay between genetic, epigenetic, and environmental factors leading to immune dysregulation, synovial membrane inflammation, and…
  • Abstract Number: 0801 • ACR Convergence 2023

    LncRNA PIGL-217 Regulates Th17 Differentiation by Targeting miR-5008-5p and Suppressing FoxO1 in Behçet’s Disease

    Zhimian Wang, Xin Yu, Hua Chen and Wenjie Zheng, Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Beijing, China

    Background/Purpose: Dysregulated Th17 cells are implicated in Behçet's disease (BD). However, the underlying mechanism remains unclear. Here we aim to elucidate the mechanism of forkhead…
  • Abstract Number: 0952 • ACR Convergence 2023

    Unraveling the Role of MiR-181 in Skin Fibrosis Pathogenesis by Targeting NUDT21

    Tingting Mills1, Minghua Wu2, Hydia Puente3, Jerry Alonso4, Julio charles4, Maureen Mayes4 and Shervin Assassi5, 1Biochemistry Department, University of Texas McGovern Medical School, Houston, TX, 2Department of Internal Medicine, Division of Rheumatology, The University of Texas Health Science Center at Houston, Houston, TX, 3UTHealth-Houston, Houston, TX, 4Division of Rheumatology, University of Texas McGovern Medical School, Houston, TX, 5University of Texas McGovern Medical School at Houston, Houston, TX

    Background/Purpose: Nudix Hydrolase 21 (NUDT21, also known as CFIm25) is a master regulator of alternative polyadenylation. Previous studies have revealed that NUDT21 is significantly decreased…
  • Abstract Number: 0023 • ACR Convergence 2022

    New Biomarkers in Hand Osteoarthritis: The Micro-RNA Signature

    Maxime Auroux1, Marjorie Millet2, Blandine Merle2, Elisabeth Fontanges1, Florence Duvert1, Evelyne Gineyts3, Jean-Charles Rousseau3, Olivier Borel2, Alexandre Mercier1, Eric LESPESSAILLES4 and Roland Chapurlat1, 1Hospices Civils de Lyon, LYON, France, 2INSERM U1033, LYON, France, 3INSERM 1033, Lyon, France, 4Regional hospital centre of Orleans, France, ORLEANS, Centre, France

    Background/Purpose: Hand osteoarthritis (HOA) is a highly prevalent disease, associated with important disability and socio-economic burden. Erosive HOA, almost exclusively found in women, induces more…
  • Abstract Number: 0257 • ACR Convergence 2022

    High Density Lipoprotein Bound miR-1246 Is Enriched in Patients with Rheumatoid Arthritis and Is Proinflammatory

    Qiong Wu, Quanhu Sheng, Danielle Michell, Kasey Vickers and Michelle Ormseth, Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: High density lipoprotein (HDL) is known for its anti-atherogenic cholesterol efflux and antioxidant functions. HDL has additional relevance to rheumatoid arthritis (RA) because of…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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