methylation and systemic lupus erythematosus (SLE) Archives

Abstract Number: 178 • ACR/ARHP Annual Meeting 2017
Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population
Maria Teruel¹, Patrick Coit², Mikhail Dozmorov³, Mario Cardiel⁴, Ignacio Garcia-De La Torre⁵, Marco A Maradiaga-Ceceña Sr.⁶, José Francisco Moctezuma⁷, Maria Teresa Tusié-Luna⁸, Marta Alarcón-Riquelme^9,10 and Amr H Sawalha², ¹GENYO, Center for Genomics and Oncological Research Pfizer/University of Granada/Andalusian Regional Government, Granada, Spain, ²Division of Rheumatology, University of Michigan, Ann Arbor, MI, ³Department of Biostatistics, Virginia Commonwealth University, Richmond, VA, ⁴Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, ⁵Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, ⁶Hospital General de Culiacán, Culiacán, Mexico, ⁷Servicio de Reumatología, Hospital General de Mexico, Ciudad de Mexico, Mexico, ⁸Medicina Genómica y Toxicología Ambiental, Universidad Nacional Autonoma de Mexico, Ciudad de Mexico, Mexico, ⁹Uppsala University, Uppsala, Sweden, ¹⁰Centro de Genomica e Investigación Oncológica, Pfizer-University of Granada-Junta de Andalucía, Granada, Spain
Background/Purpose: Our knowledge about the pivotal role DNA methylation plays in the pathogenesis of SLE has significantly increased in the last few years. However, we…
Abstract Number: 2519 • ACR/ARHP Annual Meeting 2013
A Systemic Lupus Erythematosus (SLE) Diagnostic Test Based On DNA Methylation Signatures From Peripheral Blood Mononuclear Cells
David W. Anderson¹, Robert Shoemaker², Kurt Krummel³, Zachary Hornby⁴ and Jonathan E. Lim¹, ¹Research and Development, IGNYTA, Inc., San Diego, CA, ²Bioinformatics, IGNYTA, Inc., San Diego, CA, ³Research and Development-Assay Development, IGNYTA, Inc., San Diego, CA, ⁴Business Development, IGNYTA, Inc., San Diego, CA
Background/Purpose: The heterogeneous nature of SLE and a lack of reliable biomarkers make SLE a challenge to classify in patients. A differential diagnosis of SLE…
Abstract Number: 2332 • ACR/ARHP Annual Meeting 2012
Suppression of PP2Ac Causes DNA Hypermethylation Through Enhanced Pmek/Perk Activity in T Cells
Katsue S. Watanabe¹, Kamalpreet Nagpal² and George C. Tsokos³, ¹Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, ²Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA
Background/Purpose: Although many reports have focused on the impaired MEK-ERK signaling pathway in T cells from systemic lupus erythematosus (SLE) patients which results in suppression…
Abstract Number: 2284 • ACR/ARHP Annual Meeting 2012
Epigenetic Profiling in Monozygotic Twins Discordant for Systemic Lupus Erythematosus Reveals Prominent Hypomethylation of Interferon-Inducible Genes
Paula S. Ramos¹, Timothy D. Howard², Miranda C. Marion³, Satria Sajuthi⁴, Jennifer A. Kelly⁵, Kathy L. Moser⁵ and Carl D. Langefeld⁴, ¹Department of Medicine, Medical University of South Carolina, Charleston, SC, ²Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, ³Department of Biostatistical Sciences, Wake Forest University Health Sciences, Winston-Salem, NC, ⁴Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, ⁵Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune inflammatory disease. In addition to genetic and environmental influences, the discordance rate between monozygotic (MZ)…
Abstract Number: 2269 • ACR/ARHP Annual Meeting 2012
The Differences of DNA Methylome and Transcriptome Among Diverse Clinical Manifestations of Systemic Lupus Erythematosus
Ming Zhao¹, Shuangyan Luo¹, Honglong Wu², Siyang Liu², Meini Tang¹, Wenjing Cheng¹, Qing Zhang¹, Xinhai Yu¹, Tak Mao Chan³, Yudong Xia², Na Yi², Fei Gao², Li Wang², Ning Li² and Qianjin Lu⁴, ¹Department of Dermatology, Second Xiangya Hospital, Central South University; Hunan Key Laboratory of Medical Epigenomics, Changsha, China, ²Beijing Genomics Institute at Shenzhen, Shenzhen, China, Shenzhen, China, ³Division of Nephrology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China, ⁴Department of Dermatology, Second Xiangya Hospital, Central South University, Changsha, China
Background/Purpose: Aberrant DNA methylation and gene expression have been observed in systemic lupus erythematosus (SLE). However, patterns of DNA methylation and gene expression associated with…
Abstract Number: 2270 • ACR/ARHP Annual Meeting 2012
The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)
Robert Shoemaker¹, Lou H. Bookbinder², David L. Boyle³, Gary S. Firestein⁴, Jonathan E. Lim⁵ and David W. Anderson⁶, ¹Bioinformatics, NexDx, Inc., San Diego, CA, ²Molecular Biology, NexDx, Inc., San Diego, ³Div of Rheum, UCSD School of Medicine, La Jolla, CA, ⁴Div of Rheumatology, UCSD School of Medicine, La Jolla, CA, ⁵Research and Development, NexDx, Inc., San Diego, ⁶Research and Development, NexDx, Inc., San Diego, CA
Background/Purpose: SLE is a disease where epigenetic mechanisms play a role. Methylation of DNA at CpG loci is known to influence the suppression or activation…

Abstracts tagged "methylation and systemic lupus erythematosus (SLE)"

Genome-Wide DNA Methylation Study in Lupus in an Admixed Mexican Population

A Systemic Lupus Erythematosus (SLE) Diagnostic Test Based On DNA Methylation Signatures From Peripheral Blood Mononuclear Cells

Suppression of PP2Ac Causes DNA Hypermethylation Through Enhanced Pmek/Perk Activity in T Cells

Epigenetic Profiling in Monozygotic Twins Discordant for Systemic Lupus Erythematosus Reveals Prominent Hypomethylation of Interferon-Inducible Genes

The Differences of DNA Methylome and Transcriptome Among Diverse Clinical Manifestations of Systemic Lupus Erythematosus

The DNA Methylome of Systemic Lupus Erythematosus (SLE) From Whole Peripheral Blood Mononuclear Cells (PBMCs)