Abstracts tagged "methylation and microbiome"

Abstract Number: 2334 • 2017 ACR/ARHP Annual Meeting
Hypermethylation of NLRP3 Promoter Region Could be Responsible for Decreased Gene Expression, Inflammasome Malfunction and Gut Dysbiosis in Juvenile Spondyloarthritis Patients
Lovro Lamot^1,2, Kristina Gotovac Jercic³, Antonela Blazekovic³, Mirta Lamot⁴, Mandica Vidovic⁴, Fran Borovecki³ and Miroslav Harjacek^3,4, ¹Department of Pediatrics, University of Zagreb School of Medicine, Zagreb, Croatia, ²Department of Pediatrics, Division of Clinical Immunology and Rheumatology, Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia, ³University of Zagreb School of Medicine, Zagreb, Croatia, ⁴Clinical Hospital Center Sestre Milosrdnice, Zagreb, Croatia
Background/Purpose: Juvenile spondyloarthritis (jSpA) is a complex disease with both genetic and environmental factors contributing to the etiology. Recently obtained gene signatures in jSpA patients…