Abstracts tagged "methylation"

Abstract Number: 0352 • ACR Convergence 2021
Native American and African American Rheumatic Disease Patients Exhibit Accelerated Biological Aging Compared to European Americans
Joseph Kheir, Carla Guthridge, Nicolas Dominguez, Wade DeJager, Sarah Cooper, Joel Guthridge and Judith James, Oklahoma Medical Research Foundation, Oklahoma City, OK
Background/Purpose: The universal process of aging is associated with increased risk of disease and death as a result of changing physiologic and molecular processes. In…
Abstract Number: 74 • 2018 ACR/ARHP Annual Meeting
DNA Methylation of the Dual Specificity Protein Phosphatase 22 (DUSP22) Gene Promoter in Plasma of Patients with Seropositive and Seronegative RA
Milena Rodriguez Alvarez¹, Lissette Delgado-Cruzata², Edgardo Guzman³, Wallis Tavarez³, Alorah Bliese², Tagir Sabirov³, Maria-Jose Jimenez³, Carmen A Oviedo Hilario³, Manuel E. Acosta⁴, Maria Albarracin², Carl Cirilli², Zuleika Parra³, Cristabel Robles Hidalgo³, Christopher Mesa³, Dominyka Bitinaite³, Sabeeda Kadavath³, Ibrahim El Husseini³, Grace Thomas³, Augustas Kavaliauskas³, Kioumars Bolourian Kashi³, Michael Gebeyehu³, Dave Samip³, Pawan Suri³, Menachem Gold³ and Shante Hinson³, ¹Rheumatology, SUNY Downstate, Brooklyn, NY, ²Sciences, John Jay College, City University of New York, New York, NY, ³Lincoln Medical and Mental Health Center, Bronx, NY, ⁴Barry University, Miami, FL
Background/Purpose: The Dual specificity protein phosphatase 22 (DUSP22) gene is aberrantly methylated in mononuclear cells in RA, and it has been associated with erosive disease.…
Abstract Number: 579 • 2018 ACR/ARHP Annual Meeting
Changes in DNA Methylation Identify Response to Treatment with Methotrexate and TNF Inhibitors Among RA Patients
Cameron Adams¹, Katie Marker¹, Melissa Krueger², Lisa Barcellos¹ and Lindsey A. Criswell³, ¹School of Public Health, UC Berkeley, Berkeley, CA, ²UC San Francisco, San Francisco,, CA, ³University of California San Francisco, San Francisco, CA
Background/Purpose: Epigenetic modifications including DNA methylation are implicated in the development and progression of autoimmune diseases, such as rheumatoid arthritis [MIM 180300]. Evidence indicates that…
Abstract Number: 1966 • 2018 ACR/ARHP Annual Meeting
Transcriptome and Methylome Integrative Molecular Analysis Uncovers a New Systemic Autoimmune Disease Classification
Guillermo Barturen¹, Sepideh Babaei², Francesc Catala-Moll³, Zuzanna Makowska², Antonio García-Gómez³, Anne Buttgereit⁴, Elena Carnero-Montoro¹, Sikander Hayat⁴, Martin Kerick⁵, Thomas Charlon⁶, David C Gemperline⁷, Lucas Le Lann⁸, Rosa Quirantes-PIné⁹, Isabel Borrás-Linares¹⁰, Brian Muchmore¹, Jorge Kageyama⁴, Javier Rodríguez-Ubreva³, Alvaro Fernández-Ochoa⁹, Pedro Carmona Sanz¹¹, Christophe Jamin⁸, Ralf Lesche², Robert J. Benschop⁷, Chris Chamberlain¹², Ernst R. Dow⁷, Tania Gomes¹, Maria Juárez¹³, Laurence Laigle¹⁴, Jacqueline Marovac¹², Fiona MacDonald¹⁵, Jerome Wojcik⁶, Esteban Ballestar¹⁶, Lorenzo Beretta¹⁷, Maria Orietta Borghi¹⁸, Johan Frostegård¹⁹, Maria Luisa Garcia²⁰, Javier Martín⁵, Jacques-Olivier Pers⁸, Yves Renadineau²¹, Antonio Segura Carretero⁹ and Marta Alarcón-Riquelme^1,19, ¹Medical Genomics, Center for Genomics and Oncological Research (GENYO), Granada, Spain, ²Pharmaceuticals Division, Bayer Pharma Aktiengesellschaft, Berlin, Germany, ³Cancer Epigenetics and Biology Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ⁴Bayer Pharma Aktiengesellschaft, Berlin, Germany, ⁵Institute of Parasitology and Biomedicine López Neyra, Spanish National Research Council, Granada, Spain, ⁶QuartzBIO, SA, Geneva, Switzerland, ⁷Eli Lilly and Company, Indianapolis, IN, ⁸U1227, Université de Brest, Inserm, Labex IGO, CHU de Brest, Brest, France, ⁹Department of Analytical Chemistry, University of Granada, Granada, Spain, ¹⁰Analytical Chemistry, University of Granada, Granada, Spain, ¹¹Unit of Bioinformatics, Center for Genomics and Oncological Research (GENYO), Pfizer-University of Granada-Andalusian Regional Government, Health Sciences Technology Park, Granada, Spain, ¹²UCB Pharma, Slough, United Kingdom, ¹³UCB, Slough, United Kingdom, ¹⁴Institut de Recherches Internationales Servier, Suresnes, France, ¹⁵Bayer Pharma G, Berlin, Germany, ¹⁶Cancer Epigenetics and Biology Programme (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, ¹⁷Scleroderma Unit, Referral Center for Systemic Autoimmune Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy, ¹⁸University of Milan, IRCCS Istituto Auxologico Italiano, Milan, Italy, ¹⁹Unit for Chronic Inflammatory Diseases, Institute for Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, ²⁰Nano-Imaging, BIONAND. Centro Andaluz de Nanotecnología y Biomedicina, Malaga, Spain, ²¹U1227, Université de Brest, inserm, Labex IGO, CHU de brest, Brest, France
Background/Purpose: Systemic autoimmune diseases (SADs) are chronic inflammatory conditions with autoimmune aetiology and many common clinical features, difficulting diagnosis and adequate treatment decisions. Finding new…
Abstract Number: 1011 • 2017 ACR/ARHP Annual Meeting
Mitochondrial Haplogroups-Mediated Methylation Regulates Apoptosis in Osteoathritis Cartilage
Ignacio Rego-Pérez¹, Estefanía Cortés-Pereira¹, Juan Fernández-Tajes Sr.², Mercedes Fernandez Moreno¹, Maria Eugenia Vazquez Mosquera¹, Sara Relaño-Fernandez³, Natividad Oreiro⁴, Carlos Fernandez-Lopez¹ and Francisco J Blanco¹, ¹Servicio de Reumatología. Area Genomica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ²The Wellcome Trust Center for Human Genetics. McCarthy´s Group. University of Oxford, Oxford, United Kingdom, ³Plataforma de Genómica. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC), A Coruña, Spain, ⁴1) Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruna, Spain
Background/Purpose: Recent studies revealed that haplogroup J associates with a decreased rate of incident knee Osteoarthritis. Among the functional characteristics of this haplogroup, lower rates…
Abstract Number: 3006 • 2015 ACR/ARHP Annual Meeting
Cell-Free Circulating DNA in Systemic Sclerosis: Increased Levels and Global Cytosine Hypomethylation
Shadia Nada¹, Omar Oraibi², Farouk Abu Alhana², Nawaf Almeshal², Yongqing Wang², Nezam Altorok³ and Bashar Kahaleh⁴, ¹Internal Medicine, Divison of Rheumatology, The University of Toledo, Toledo, OH, ²The University of Toledo, Toledo, OH, ³Internal Medicine, Division of Rheumatology, The University of Toledo, Toledo, OH, ⁴Medicine/Rheumatology, The University of Toledo, Toledo, OH
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by endothelial dysfunction, vascular injury, and activation of fibroblasts leading to organ fibrosis. The precise etiology…
Abstract Number: 2919 • 2014 ACR/ARHP Annual Meeting
The Novel Rheumatoid Arthritis (RA) Risk Gene, LBH, Is Regulated By TGFß and PDGF and Modulates Cell Growth in Fibroblast-like Synoviocytes
Anna-Karin Ekwall¹, Deepa Hammaker², John W. Whitaker³, William Bugbee⁴, Wei Wang⁵ and Gary S. Firestein⁶, ¹Medicine, UC San Diego, La Jolla, CA, ²Medicine, University of California San Diego, La Jolla, CA, ³860 island ave, UCSD, San Diego, CA, ⁴Orthopaedics, Scripps Clinic, La Jolla, CA, ⁵Chemistry, UCSD, La Jolla, CA, ⁶Division of Rheumatology, Allergy and Immunology, University of California at San Diego School of Medicine, La Jolla, CA
Background/Purpose: RA fibroblast-like synoviocytes (FLS) display an aggressive phenotype, such as increased cytokine production and cell growth. Currently no therapeutics specifically target FLS. To this…
Abstract Number: 2087 • 2014 ACR/ARHP Annual Meeting
Defective Regulation of L1 Endogenous Retroelements in Primary Sjogren’s Syndrome and Systemic Lupus Erythematosus: Role of Methylating Enzymes
Clio Mavragani¹, Adrianos Nezos², Irina Sagalovskiy³, Surya V. Seshan⁴, Kyriakos A. Kirou⁵, Haralampos M. Moutsopoulos⁶ and Mary K. Crow³, ¹Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ³Department of Medicine, Hospital for Special Surgery, New York, NY, ⁴Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece
Background/Purpose: To investigate whether deranged methylating mechanisms are involved in the inappropriate expression of LINE-1 (L1) retroelements in primary Sjogren’s syndrome (SS) and systemic lupus…
Abstract Number: 1033 • 2014 ACR/ARHP Annual Meeting
Stat3 Promotes IL-10 Expression in SLE T Cells through Trans-activation and Chromatin Remodeling
Christian Hedrich¹, Thomas Rauen², Sokratis Apostolidis³, Alexandros P. Grammatikos⁴, Noe Rodriguez Rodriguez⁴, Christina Ioannidis³, Vasileios C. Kyttaris⁴, José C. Crispin⁴ and George C. Tsokos⁵, ¹Children's Hospital, Dresden, Germany, ²Medicine/Rheumatology, BIDMC, Harvard Medical School, Boston, MA, ³Medicine, Rheumatology, BIDMC, Boston, MA, ⁴Medicine/Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ⁵Rheumatology, Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA
Background/Purpose: IL-10 is an immune-regulatory cytokine that is expressed by a wide range of cells and tissues. It plays a central role in the regulation…

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