methotrexate (MTX) and pediatrics Archives

Abstract Number: 2391 • ACR/ARHP Annual Meeting 2018
Methotrexate Polyglutamates As an Evaluation Tool for Appropriate Dosage of Oral Methotrexate Administration in Pediatric Patients
Nami Okamoto¹, Kosuke Shabana², Yasuo Nakagishi³, Kenichi Nishimura⁴, Mao Mizuta⁵, Yuka Okura⁶, Masaki Shimizu⁵, Hiroyuki Wakiguchi⁷, Junko Yasumura⁸ and Masaaki Mori⁹, ¹Pediatrics, Osaka Medical College, Takatsuki, Japan, ²Department of Pediatrics, Osaka Medical College, Takatsuki, Japan, ³Department of Pediatric Rheumatology, Hyogo Prefectural Kobe Children’s Hospital, Kobe, Japan, ⁴Department of Pediatrics, Yokohama City University Graduate School of Medicine, Yokohama, Japan, ⁵Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan, ⁶Department of Pediatrics, KKR Sapporo Medical Center, Sapporo, Japan, ⁷Department of Pediatrics, Yamaguchi University Graduate School of Medicine, Ube, Japan, ⁸Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan, ⁹Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
Background/Purpose: Since MTX metabolism varies depending on age and dosage, we need to know optimal MTX administration method in children. We performed multi-center prospective study…
Abstract Number: 2207 • ACR/ARHP Annual Meeting 2013
Plasma Cytokine Concentrations Are Associated With Folate Perturbations and Methotrexate Polyglutamate Accumulation In The Peripheral Blood Of Juvenile Idiopathic Arthritis Patients Treated With Low-Dose Methotrexate
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, J.S. Leeder¹ and Mara L Becker⁶, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Methotrexate inhibits the production of inflammatory cytokines, but is also an antifolate. The activity of MTX is thought to depend on the formation of…

Abstracts tagged "methotrexate (MTX) and pediatrics"

Methotrexate Polyglutamates As an Evaluation Tool for Appropriate Dosage of Oral Methotrexate Administration in Pediatric Patients

Plasma Cytokine Concentrations Are Associated With Folate Perturbations and Methotrexate Polyglutamate Accumulation In The Peripheral Blood Of Juvenile Idiopathic Arthritis Patients Treated With Low-Dose Methotrexate