Abstracts tagged "metabolomics and rheumatoid arthritis (RA)"

Abstract Number: 205 • 2018 ACR/ARHP Annual Meeting
Circulating Plasma Metabolites and Risk of Rheumatoid Arthritis in the Nurses Health Study
Su Chu^1,2, Jeffrey A. Sparks^1,3, Jing Cui⁴, Sara K. Tedeschi^3,5, Cameron Speyer³, Cianna Leatherwood^1,3, Medha Barbhaiya⁶, Clary Clish⁷, Kevin D. Deane⁸, Jessica Su^1,2, Karen Costenbader^1,3 and Elizabeth Karlson^1,9, ¹Medicine, Harvard Medical School, Boston, MA, ²Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, ³Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Boston, MA, ⁴Rheumatology and Immunology, Brigham and Women's Hospital, Boston, MA, ⁵American College of Rheumatology, Atlanta, GA, ⁶Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ⁷Broad Institute of MIT and Harvard, Boston, MA, ⁸Division of Rheumatology, University of Colorado Denver, Aurora, CO, ⁹Rheumatology/Immunology, Brigham and Women's Hospital, Boston, MA
Background/Purpose: Rheumatoid arthritis (RA) develops insidiously, often over many years. Given that diet and obesity have been associated with increased RA risk, we investigated whether…
Abstract Number: 1061 • 2018 ACR/ARHP Annual Meeting
Serum Metabolomic Profiling Predicts Synovial Gene Expression in Rheumatoid Arthritis
Rekha Narasimhan¹, Roxana Coras^1,2, Sara B Rosenthal³, Shannon R Sweeney⁴, Alessia Lodi⁵, Stefano Tiziani⁶, David L. Boyle¹, Arthur Kavanaugh⁷ and Monica Guma^1,2, ¹Medicine, University of California San Diego, La Jolla, CA, ²Medicine, Autonomous University of Barcelona, Bellatera, Spain, ³Center for Computational Biology and Bioinformatics, University of California San Diego, San Diego, CA, ⁴Department of Nutritional Sciences. The University of Texas at Austin., Austin, TX, ⁵Department of Nutritional Sciences & Dell Pediatric Research Institute, Dell Medical School, University of Texas at Austin, Austin, TX, ⁶Dell Medical School, University of Texas at Austin, Austin, TX, ⁷University of California, San Diego, School of Medicine, La Jolla, CA
Background/Purpose: Metabolomics is an emerging field of biomedical research that may offer a better understanding of mechanisms underlying conditions that could include inflammatory arthritides. Perturbations…
Abstract Number: 1074 • 2018 ACR/ARHP Annual Meeting
Distinct Metabolic Profile in the Urine of Rheumatoid Arthritis Patients:a Possible Link to Arthritis Phenotypes
JungHee Koh¹, Yune-Jung Park², Hong-Ki Min³, Moon Young Kim⁴, Seung-Ah Yoo⁵, Chul-Soo Cho⁶ and Wan-Uk Kim⁷, ¹Division of Rheumatology, Department of Internal Medicine, Pusan National University School of Medicine, Pusan National University Hospital, Busan, Korea, Republic of (South), ²Internal Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Gyeonggido, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine,College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁵The Catholic University of Korea, Center for Integrative Rheumatoid Transcriptomics and Dynamics, seoul, Korea, Republic of (South), ⁶Internal Medicine, Yeouido St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of (South), ⁷Division of Rheumatology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, seoul, Korea, Republic of (South)
Background/Purpose: A great deal of recent attention has been directed at a possible link between intestinal microbial metabolism and inflammation. Metabolites represent the intermediate products…
Abstract Number: 1442 • 2018 ACR/ARHP Annual Meeting
Differential Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry and a Universal Metabolome Standard Reveals a Metabolome Profile with Consistent Accuracy for Rheumatoid Arthritis
Walter P. Maksymowych¹, Xiaohang Wang², Joel Paschke¹, Rana Dadashova¹, Edna Hutchings¹ and Liang Li², ¹CaRE Arthritis, Edmonton, AB, Canada, ²Chemistry, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) is hampered by suboptimal accuracy of currently available serological biomarkers. Recent advancements in metabolomic profiling include dansylation liquid…
Abstract Number: 1025 • 2017 ACR/ARHP Annual Meeting
Submetabolome Profiling with Differential Chemical Isotope Labeling Liquid Chromatography Mass Spectrometry and a Universal Metabolome Standard Reveals a Metabolite Profile with 99% Accuracy for Rheumatoid Arthritis
Walter P. Maksymowych¹, Derrick Blackmore², Roman Eisner³, Liang Li⁴ and Zaeem Siddiqi², ¹Department of Medicine, University of Alberta, Edmonton, AB, Canada, ²Medicine, University of Alberta, Edmonton, AB, Canada, ³City of Edmonton, Edmonton, AB, Canada, ⁴Chemistry, University of Alberta, Edmonton, AB, Canada
Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) is hampered by suboptimal accuracy of currently available serological biomarkers. Recent advancements in metabolomic profiling include dansylation liquid…
Abstract Number: 1115 • 2016 ACR/ARHP Annual Meeting
Non-Esterified Fatty Acids Are Associated with Clinical Features and an Enhanced Th1 Response in Rheumatoid Arthritis: Towards Disease Profiling
Javier Rodríguez-Carrio¹, Mercedes Alperi-López², Patricia López¹, Francisco Javier Ballina-García² and Ana Suárez¹, ¹Area of Immunology, Department of Functional Biology, University of Oviedo, Oviedo, Spain, ²Department of Rheumatology, Hospital Universitario Central de Asturias, Asturias, Spain
Background/Purpose: Non-Esterified Fatty Acids (NEFA) are important lipid mediators which can play a role in a number of biological functions other than energy supply. NEFA…
Abstract Number: 2694 • 2015 ACR/ARHP Annual Meeting
Variations in the Metabolome in Response to Disease Activity of Rheumatoid Arthritis
Zuzana Tatar¹, Carole Migne², Mélanie Petera³, Estelle Pujos Guillot⁴, Philippe Gaudin^5,6, T Lequerré⁷, Hubert Marotte⁸, Jacques Tebib⁹ and Martin Soubrier¹, ¹Rheumatology department CHU Clermont-Ferrand, Clermont-Ferrand, France, ²Metabolomic Plateform INRA, Theix-Clermont-Ferrand, France, ³Metabolomic Plateform, INRA, Theix -Clermont-Ferrand, France, ⁴Metabolomic Plateform, INRA, Theix-Clermont-Ferrand, France, ⁵Rheumatology, University Hospital, Grenoble, France, ⁶Rheumatology Department, CHU Hôpital Sud, Grenoble Teaching Hospital, Echirolles, France, ⁷Rheumatology Department and INSERM U 905, CHU Hôpitaux de Rouen, Rouen, France, ⁸INSERM 1059 / LBTO, Université de Lyon, Saint-Etienne; Rheumatology Department, Saint-Etienne, France, ⁹Rheumatology Department, Centre Hospitalier Lyon-Sud, Pierre-Bénite Lyon, France
Background/Purpose: Anti-TNF-alpha therapies are able to control rheumatoid arthritis (RA) disease activity and to limit structural damage. Nevertheless, no predictive factor of response to anti-TNF-alpha,…

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