ACR Meeting Abstracts

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Abstracts tagged "metabolic syndrome"

  • Abstract Number: 0335 • ACR Convergence 2024

    Analysis of the Prevalence of Diabetes Mellitus in Patients with Adult-onset Dermatomyositis

    Komal Ejaz1, Chao Zhang2 and Soumya Chatterjee3, 1Cleveland Clinic, Cleveland, OH, 2Cleveland Clinic, Cleveland Heights, OH, 3Cleveland Clinic, Richmond Heights, OH

    Background/Purpose: Dermatomyositis is an idiopathic inflammatory myopathy with proximal muscle weakness and skin manifestations. Myositis patients have poor overall health partially due to co-morbidities. Data…
  • Abstract Number: 0471 • ACR Convergence 2024

    Understanding the Role of the Complement System in Insulin Resistance and Metabolic Syndrome in Patients with Rheumatoid Arthritis

    Jose Viotti-Serra1, Maria Garcia-Gonzalez2, Fuensanta Gomez-Bernal1, Juan Carlos Quevedo-Abeledo3, Miguel Angel Gonzalez-Gay4 and ivan Ferraz-Amaro5, 1Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain, 2Hospital Universitario de Canarias, SC Tenerife, Canarias, Spain, 3Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de GC, Canarias, Spain, 4University of Cantabria, Fundación Jimenez Díaz, Madrid, Madrid, Spain, 5Rheumatology, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Canarias, Spain

    Background/Purpose: The complement (C) system has been associated with the etiopathogenesis of rheumatoid arthritis (RA). Insulin resistance (IR) and metabolic syndrome are prevalent among RA…
  • Abstract Number: 0803 • ACR Convergence 2024

    Serum Adipokines and Interstitial Lung Disease in a Prospective Rheumatoid Arthritis Cohort

    Anna Haggart1, Joshua Baker2, Tate Johnson3, Yangyuna Yang3, Punyasha Roul4, Katherine Wysham5, grant Cannon6, Gary Kunkel7, Dana Ascherman8, Paul Monach9, Gail Kerr10, Andreas Reimold11, Michael Duryee3, Geoffrey Thiele3, Ted Mikuls3 and Bryant England3, 1University of Nebraska Medical Center, Omaha, 2University of Pennsylvania, Philadelphia, PA, 3University of Nebraska Medical Center, Omaha, NE, 4UNMC, Omaha, NE, 5VA PUGET SOUND/UNIVERSITY OF WASHINGTON, Seattle, WA, 6University of Utah and Salt Lake City VA, Salt Lake City, UT, 7University of Utah and George E Wahlen VAMC, Salt Lake City, UT, 8Division of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, 9VA Boston Healthcare System, Boston, MA, 10Washington DC VAMC/Georgetown and Howard Universities, Washington, DC, 11Dallas VA Medical Center, Dallas, TX

    Background/Purpose: Adipokines are metabolic cytokines shown to be dysregulated in RA and prognostic of RA-related complications such as cardiovascular disease. Similarly, aberrations in adipokines have…
  • Abstract Number: 0992 • ACR Convergence 2024

    Visceral Adipose Tissue Measured by DXA Predicts Metabolic Syndrome in Low-Income Community-Dwelling Elderly: Insights from the São Paulo Ageing & Health (SPAH) Study

    Gabriel Vansuita Valente1, Luana Machado1, Andre Franco2, Valeria Caparbo1, Liliam Takayama3, Alan Lins Fernandes1, Camille Figueiredo1, Rosa M R Pereira1 and Diogo Domiciano2, 1Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., São Paulo, SP, Brazil, 2Rheumatology Division, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil, São Paulo, SP, Brazil, 3Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, São Paulo, SP, Brazil

    Background/Purpose: To establish optimal cutoffs for visceral adipose tissue (VAT) to predict cardiometabolic risk in a low-income elderly Brazilian cohort, utilizing dual-energy X-ray absorptiometry (DXA)…
  • Abstract Number: 1094 • ACR Convergence 2024

    Longitudinal Analysis of Serum Urate in Prediabetic Phase

    Javier Marrugo1, Leah Santacroce1, Misti Paudel2, Sho Fukui3, Sara Tedeschi1 and Daniel Solomon4, 1Brigham and Women's Hospital, Boston, MA, 2Brigham and Women's Hospital, Division of Rheumatology, Inflammation, and Immunity, Boston, MA, 3Brigham and Women's Hospital, Brookline, MA, 4Brigham and Women's Hospital, Newton, MA

    Background/Purpose: More than 460 million people worldwide are currently living with prediabetes, a condition that not only predisposes individuals to diabetes (DM) but also to…
  • Abstract Number: 1099 • ACR Convergence 2024

    Distinct Metabolomic Signatures of Insulinemia and Incident Gout Risk: A Prospective Cohort Study Among Women

    Sharan Rai1, Hyon K. Choi2, Chio Yokose1 and Natalie McCormick1, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout and the metabolic syndrome frequently coexist. Intravenous insulin has been shown to raise serum urate levels in physiologic studies, and a Mendelian Randomization…
  • Abstract Number: 1198 • ACR Convergence 2024

    Impact of Metabolic Syndrome on Knee Osteoarthritis Severity and Progression: A PROCOAC Cohort Study

    Natividad Oreiro1, Ana Raga2, Vanesa Balboa-Barreiro3, Ignacio Rego-Perez4, Belen Acasuso5, Laura Galindo Domínguez6 and francisco J Blanco7, 1CHUAC, La Coruna, Galicia, Spain, 2Grupo de Investigación en Reumatología (GIR). INIBIC-Complejo Hospitalario Universitario A Coruña (CHUAC). SERGAS, A Coruña, Spain, 3Unidad de Epidemiología Clínica y Bioeostadística. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC)., A Coruña, Spain, 4Instituto de Investigacion Biomedica de A Coruña-SERGAS, A Coruña, Spain, 5Unidad de Investigacion Clinica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas., Investigation, A Coruña, Spain, A Coruña, Spain, 6Instituto de Investigacion Biomedica de A Coruña (INIBIC), A Coruña, Spain, 7INIBIC-University of A Coruña, A Coruña, Spain

    Background/Purpose: The contribution of metabolic factors to the development of osteoarthritis (OA) has not been fully elucidated. The aim of this study is to analyze…
  • Abstract Number: 1463 • ACR Convergence 2024

    Investigation of the Cardiometabolic-related Mechanism of Action of Apremilast Through Plasma Proteomics Profiling of Patients with Psoriasis or Psoriatic Arthritis from Three Phase 3 Studies

    A. Francesca Setiadi1, Maggie Burhans2, Xuguang Hu2, Stephen Colgan3, Kim Notari2, Marcia C. Teixeira dos Santos2, Apostolos Kontzias2, Sue Cheng2 and Nehal Mehta4, 1Amgen Inc., South San Francisco, CA, 2Amgen Inc., Thousand Oaks, CA, 3Amgen, Halton Hills, ON, Canada, 4The George Washington University School of Medicine, Washington, DC

    Background/Purpose: Psoriasis (PsO) and psoriatic arthritis (PsA) are associated with higher rates of obesity and cardiometabolic complications. Apremilast (APR) is an inhibitor of phosphodiesterase 4,…
  • Abstract Number: 2094 • ACR Convergence 2024

    Cross-sectional Associations of Radiographic Multiple Joint Osteoarthritis and Pain with Demographic and Clinical Characteristics: Design of a Multi-modal Study in Human and Pet Dogs

    Liubov Arbeeva1, Kelly Johnson2, Serena Savage-Guin3, Tessa Walker2, Masataka Enomoto4, Christina Stevens4, Milja Koskinen4, Tracey Cole4, Savannah Aker4, Connor Thonen-Fleck4, Richard Loeser5, Jordan Renner2, Duncan Lascelles6, Yvonne Golightly7 and Amanda Nelson8, 1University of North Carolina, Chapel Hill, Carrboro, NC, 2Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 3Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill,, Chapel Hill, NC, 4Translational Research in Pain and Comparative Pain Research and Education Center, Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, 5University of North Carolina, Chapel Hill, NC, 6North Carolina State University, Raleigh, NC, 7University of Nebraska Medical Center, Omaha, NE, 8University of North Carolina at Chapel Hill, Chapel Hill, NC

    Background/Purpose: Multiple joint osteoarthritis (MJOA) is a progressive, highly prevalent disease affecting millions of Americans and as well as pet dogs. This preliminary analysis sought…
  • Abstract Number: 2321 • ACR Convergence 2024

    Prevalence and Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease

    Nahia Plaza-Aulestia1, Oihane Ibarguengoitia-Barrena2, Blanca Sampedro-Andrada3, Cristina San Juan-Lopez3, Victoria Morillo-Montañes4, Irati Urionaguena5, Itziar Calvo6, David Montero Seisdedos7, Lucia Vega-Alvarez2, Jose Francisco Garcia Llorente2 and Nuria Vegas Revenga8, 1Rheumatology Division, Galdakao-Usansolo University Hospital, Galdakao, Spain, 2Rheumatology Division, Galdakao-Usansolo University Hospital, Bilbao, Spain, 3Digestive Division, Galdakao-Usansolo University Hospital, Galdakao, Spain, 4Dermatology Division, Galdakao-Usansolo University Hospital, Galdakao, 5Rheumatology Division, Galdakao-Usansolo University Hospital, GERNIKA-LUMO, Spain, 6Hospital Universitario de Basurto, Bilbao, Spain, 7Galdakao-Usansolo University Hospital, Bilbao, Spain, 8Hospital Galdakao- Usansolo, Galdakao, Spain

    Background/Purpose:  Patients with psoriatic disease (PsD) [psoriasis (PsO) and psoriatic arthritis (PsA)] are at greater risk of developing metabolic dysfunction-associated steatotic liver disease (MASLD) compared…
  • Abstract Number: 0133 • ACR Convergence 2024

    The Association Between Gout and Gallstone Disease: US General Population Analysis

    Chio Yokose1, Bohang Jiang2, Natalie McCormick2, Sharan Rai2 and Hyon K. Choi3, 1Massachusetts General Hospital, Waltham, MA, 2Massachusetts General Hospital, Boston, MA, 3Massachusetts General Hospital, Lexington, MA

    Background/Purpose: Gout is associated with kidney stones, but its association with gallstone disease is not known. Gout and gallstone disease have several shared risk factors…
  • Abstract Number: 0307 • ACR Convergence 2024

    Mean Metacarpophalangeal Extension to Clinically Quantify Flexor Fibro-inflammatory Hand Involvement in Diabetes

    Sanat Phatak1, Rucha Wagh2, Smita Dhadge2, Sarita Jadhav2, Parth Ladha3, Rishi Nalkande4, Rohan Shah2, Jennifer Ingram5 and Chittaranjan Yajnik2, 1KEM Hospital Research Centre, Pune, Maharashtra, India, 2KEM Hospital Research Centre, Pune, India, 3Byramjee Jeejeebhoy Government Medical College, Pune, Maharashtra, India, 4BJ Government Medical College, Pune, India, 5Duke University Medical Center, Durham, NC

    Background/Purpose: Hand manifestations (limited joint mobility, [LJM]; flexor tenosynovitis, [FT]; carpal tunnel syndrome, [CTS]; Dupuytren disease, [DD]) are common complications in diabetes. Despite their heterogeneity…
  • Abstract Number: 0095 • ACR Convergence 2023

    Kynurenine Is a Proinflammatory Metabolite That Activates a Positive Feedback Loop of Rab4A-dependent CD98 Expression and mTORC1 and mTORC2 Activation in SLE

    Thomas Winans1, Nick Huang1, Joshua Lewis1, Xiaojing Wang1, Tamas Faludi1, Daniel Krakko2, Laurence Morel3 and Andras Perl4, 1SUNY Upstate Medical University, Syracuse, NY, 2North Carolina State University, Raleigh, NC, 3University of Texas health San Antonio, San Antonio, TX, 4SUNY, Syracuse, NY

    Background/Purpose: The kynurenine (KYN) pathway has been linked to disease pathogenesis in patients with systemic lupus erythematosus (SLE) (https://pubmed.ncbi.nlm.nih.gov/26366134/). Genetically enforced overexpression of Rab4A activates…
  • Abstract Number: 0992 • ACR Convergence 2023

    Association Between Metabolic Syndrome and the Presence of Enthesophytes on Musculoskeletal Ultrasound Compared to Joint X-ray

    Sean Brown1, John Hardin2 and Shereen Mahmood3, 1Montefiore Medical Center, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3Albert Einstein College of Medicine / Montefiore Medical Center, New York, NY

    Background/Purpose: Enthesophytes consist of calcium deposition on tendons or ligaments that are proposed to form in response to localized inflammation of the enthesis, either idiopathic…
  • Abstract Number: 1116 • ACR Convergence 2023

    The Current State of Sodium-Glucose Cotransporter Type 2 Inhibitor Use Among Patients with Gout at a Tertiary Academic Healthcare System

    Chio Yokose1, Baijun Zhou1, Natalie McCormick1, Sruthi Tanikella1, Minna Kohler2, Janeth Yinh1, Yuqing Zhang3 and Hyon K. Choi4, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Harvard Medical School, Boston, MA, 3Division of Rheumatology, Allergy, and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, MA, 4Massachusetts General Hospital and Harvard Medical School, Lexington, MA

    Background/Purpose: A substantial proportion of gout patients have type 2 diabetes (T2DM), heart failure (HF), and chronic kidney disease (CKD), for which SGLT2i treatment is…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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