Abstracts tagged "Metabolic Crystal"

Abstract Number: 1135 • ACR Convergence 2025
A Gain-of-Function 5’UTR Variant in ANKH Causes Familial CPPD with Elevated Extracellular PPi and Citrate
richette pascal¹, christophe Duranton², Thomas Pinna³, Manon Ricquebourg⁴, LATOURTE Augustin⁵, Thomas Bardin⁶, Valérie Bousson⁷, Hang-Korng Ea⁸, Isabelle Rubera⁹ and Corinne Collet¹⁰, ¹Rheumatology Department, Lariboisiere Hospital, Paris, Ile-de-France, France, ²CNRS-UMR ⁷³⁷⁰ - Laboratoire de Physiomedecine moléculaire, Nice, Rhone-Alpes, France, ³INSERM U¹¹³², PARIS, Ile-de-France, France, ⁴Lariboisiere Hospital, INSERM U¹¹³², Paris, France, ⁵Rheumatology Department, Lariboisiere Hospital, Paris, France, ⁶Lariboisiere Hospital, Department of Rheumatology, Paris, France, ⁷Radiology Department, Lariboisiere Hospital, Paris, France, ⁸INSERM U¹¹³², Lariboisiere Hospital, Paris, France, ⁹CNRS-UMR ⁷³⁷⁰ - Laboratoire de Physiomedecine moléculaire, Nice, France, ¹⁰Reference Center for Skeletal Dysplasia, INSERM UMR ¹¹⁶³, Paris, France
Background/Purpose: To identify novel pathogenic variants associated with chondrocalcinosis (CC), we systematically screened individuals with a family history of CPPD using an NGS panel. Among…
Abstract Number: 1127 • ACR Convergence 2025
The Pathogenetic Role of Calcium Pyrophosphate and Basic Calcium Phosphate Crystals in Osteoarthritis: Associations with Synovial Fluid Cytokines and Clinical Indices
Francesca Oliviero¹, Chiara Baggio², Amelia Damasco², Federico Zorzi³, Mariagrazia Lorenzin², Giacomo Cozzi² and Roberta Ramonda⁴, ¹Rheumatology Unit, Department od Medicine - DIMED, University of Padova, Padova, Veneto, Italy, ²Rheumatology Unit, Department of Medicine - DIMED, University of Padova, Padova, Veneto, Italy, ³Center for Analysis and Certification Services (CEASC), University of Padova, Padova, Veneto, Italy, ⁴Rheumatology Unit-DIMED-University of Padova ITALY, Padova, Padua, Italy
Background/Purpose: Calcium pyrophosphate (CPP) and basic calcium phosphate (BCP) crystals are frequent features of synovial fluid (SF) in patients with osteoarthritis (OA). Although these crystals…
Abstract Number: 1032 • ACR Convergence 2025
Exploring the role of the gut microbiome in gout: Prospective analysis of dietary fiber intake and the risk of gout
Sharan Rai¹, Natalie McCormick², Chio Yokose³, Robert Terkeltaub⁴, Dylan Dodd⁵, Lama Nazzal⁶, Huilin Li⁶, Qi Sun⁷ and Hyon K. Choi⁸, ¹Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital, Waltham, MA, ⁴Retired, San Diego, CA, ⁵Stanford University, Palo Alto, CA, ⁶NYU Langone, New York, NY, ⁷Harvard T.H. Chan School of Public Health, Boston, ⁸MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: The role of the gut microbiome has been increasingly implicated in the pathogenesis of gout. For instance, gout patients have shown depletions of bacteria…
Abstract Number: 2590 • ACR Convergence 2025
Translating findings on urate-metabolizing bacterial genes and urate levels at the human population level: a gut microbiome analysis of three independent cohorts of men and women
Sharan Rai¹, Natalie McCormick², Xochitl Morgan³, Matthew Nayor⁴, Robert Terkeltaub⁵, Dylan Dodd⁶, Lama Nazzal⁷, Huilin Li⁷, Gary Curhan⁸, Curtis Huttenhower³ and Hyon K. Choi⁹, ¹Massachusetts General Hospital/Harvard Medical School, Boston, MA, ²Massachusetts General Hospital, Boston, MA, ³Harvard T.H. Chan School of Public Health, Boston, ⁴Boston University, Boston, ⁵Retired, San Diego, CA, ⁶Stanford University, Palo Alto, CA, ⁷NYU Langone, New York, NY, ⁸Brigham and Women's Hospital, Boston, ⁹MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA
Background/Purpose: Approximately 21% of US adults have hyperuricemia, the causal precursor for gout. Human cells do not degrade urate (due to uricase gene inactivation). However,…
Abstract Number: 0669 • ACR Convergence 2021
Early-Onset Gout (EOG) Patients Are an Important and Recalcitrant Phenotype Warranting Further Investigation: A Systematic Review
Anthony Amatucci¹, Brian LaMoreaux² and David Bulbin³, ¹Horizon Therapeutics, West Orange, NJ, ²Horizon Therapeutics plc, Deerfield, IL, ³Geisinger Health System, Danville, PA
Background/Purpose: Data suggests that the number of patients with early-onset gout (EOG), defined as patients under the age of 40 years, is increasing1. There is…
Abstract Number: 0666 • ACR Convergence 2020
Identification of Intracellular Vacuoles in Synovial Fluid with Calcium Pyrophosphate and Monosodium Urate Crystals
Maria Luisa Peral¹, Irene Calabuig¹, Ana Martín-Carratalá², Mariano Andrés¹ and Eliseo Pascual¹, ¹Hospital General Universitario de Alicante-ISABIAL and Universidad Miguel Hernández de Elche, Alicante, Spain, ²Universidad Miguel Hernández de Elche, Alicante
Background/Purpose: Synovial fluid analysis using polarized microscopy is the gold standard for the diagnosis of crystal-related arthritis. In our experience, we have noted that, when…
Abstract Number: 0684 • ACR Convergence 2020
The Shrinking Toe: A Sign of Crystal Dissolution During Urate Lowering Treatment of Severe Gouty Arthropathy
Thomas Bardin¹, Nguyen Dinh Quang², Hieu Le Nghia², Tran Minh Khoi², Hang Korng EA³, Valérie Bousson⁴ and Pascal Richette⁵, ¹Université de Paris, INSERM U1132 and Hôpital Lariboisièe, Paris, France, Paris, France, ²Vien Gut Medical Center, Ho Chi Minh City, Vietnam, ³Universite de Paris, AP-HP, INSERM, paris, France, ⁴Lariboisière Hospital, Paris, France, ⁵Department of Rheumatology, Lariboisière Hospital, Paris, France
Background/Purpose: Serum urate (SU) lowering has been reported to improve gout erosions. We observed that it may also lead to compaction of toe MTP or…

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