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Abstracts tagged "meta-analysis and osteoarthritis"

  • Abstract Number: 1304 • ACR/ARP Annual Meeting 2019

    Efficacy and Safety of Hylan G-F 20 versus Intra-Articular Corticosteroids in Patients with Knee Osteoarthritis: A Systematic Literature Review, Meta-Analysis, and Network Meta-analysis

    Xavier Chevalier 1, Brendan Sheehan 2, Craig Whittington 3, Chunyi Ho 4, Wilson Ngai5 and Gustavo Campos 6, 1Department of Rheumatology, Hospital henri Mondor, Paris University XII, Creteil, France, 2Department of Medicine, Dalhousie University, Saint John, NB, Canada, 3Doctor Evidence, Santa Monica, CA, 4Doctor Evidence, Santa Monica, 5Sanofi, U.S. Medical Affairs, Bridgewater, 6Universidade Estadual de Campinas, Campinas, Brazil

    Background/Purpose: Knee OA is a progressive joint disease which affects more than 250 million people worldwide. Meta-analysis (MA) has demonstrated that IA CS were more…
  • Abstract Number: 1200 • ACR/ARHP Annual Meeting 2017

    Updating the Knee Osteoarthritis Intra-Articular Corticosteroid Meta-Analysis with Two Large Trials of Extended-Release Triamcinolone Acetonide (FX006) Versus Placebo

    Philip G. Conaghan1, Francis Berenbaum2, Virginia B. Kraus3, James Johnson4 and Scott Kelley5, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom, 2Pierre & Marie Curie University, Saint-Antoine Hospital, Paris, France, 3Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 4Summit Analytical, Denver, CO, 5Flexion Therapeutics, Inc., Burlington, MA

    Background/Purpose: A recent meta-analysis concluded that intra-articular corticosteroids (IACS) for knee osteoarthritis (OA) may be associated with moderate improvement in pain compared with control treatment.1,2…
  • Abstract Number: 293 • ACR/ARHP Annual Meeting 2016

    A Systematic Review and Network Meta-Analysis of Long-Term Trials of Pharmacological Treatments in Knee Osteoarthritis

    Dario Gregori1, Giampaolo Giacovelli2, Clara Minto1, Beatrice Barbetta2, Francesca Gualtieri2, Danila Azzolina1, Paola Vaghi2 and Lucio C. Rovati2,3, 1Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padova, Italy, 2Clinical Research Department, Rottapharm Biotech, Monza, Italy, 3University of Milano Bicocca, Milano, Italy

    Background/Purpose: Osteoarthritis (OA) is a chronic and progressive degenerative disease. While management of OA should be directed to long-term control of symptoms and joint structure…
  • Abstract Number: 986 • ACR/ARHP Annual Meeting 2012

    Genome Wide Association Studies of Knee Osteoarthritis in 2 Large North American Cohorts: A Meta-Analysis with 2667 Cases

    Marc C. Hochberg1, Laura Yerges-Armstrong2, Changwan (Larry) Lu3, Michelle S. Yau4, Braxton D. Mitchell2, Joanne M. Jordan5, Youfang Liu6, Jordan B. Renner7, T. McSherry8, D.M. Taverna8, David Duggan9, W.J. Mysiw10 and Rebecca D. Jackson10, 1Department of Medicine, University of Maryland, Baltimore, MD, 2Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD, 3University of Maryland School of Medicine, Baltimore, MD, 4University of Maryland, Baltimore, MD, 5Thurston Arthritis Research Center, University of North Carolina, Chapel Hill, NC, 6University of North Carolina, Chapel Hill, NC, 7University of North Carolina Department of Radiology, Chapel Hill, NC, 8TGen, Pheonix, AZ, 9Translational Genomics Research Institute, Phoenix, AZ, 10Ohio State University, Columbus, OH

    Background/Purpose: A strong genetic contribution to knee osteoarthritis (OA) is widely recognized although few loci have been robustly associated with knee OA susceptibility. To identify…
  • Abstract Number: 257 • ACR/ARHP Annual Meeting 2012

    Meta-Analysis of Four 12-Week Phase III Clinical Trials Investigating the Effect of TDT 064, a Transdermal Gel, in Osteoarthritis of the Knee

    Matthias Rother1, Johannes C. Vester2, Wolfgang W. Bolten3 and Philip G. Conaghan4, 1IMR Partner GmbH, Graefelfing, Germany, 2IDV Data Analysis and Study Planning, Krailling, Germany, 3Rheumatology, Klaus-Miehlke-Klink, Wiesbaden, Germany, 4University of Leeds, Leeds, United Kingdom

    Background/Purpose: A transfersome is an ultradeformable lipid vesicle originally developed to deliver high concentrations of drug (eg NSAIDs) transdermally. Large interventional trials in osteoarthritis (OA)…

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