Abstracts tagged "Mesenchymal stem cells and systemic lupus erythematosus (SLE)"

Abstract Number: 1872 • 2018 ACR/ARHP Annual Meeting
Safety and Efficacy of Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus: Results of an Open-Label Phase I Study
Diane L. Kamen¹, Paul J. Nietert², Hongjun Wang³, Tara Duke³, Colleen Cloud³, Angela Robinson³ and Gary S. Gilkeson⁴, ¹Medicine/Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ²Public Health Sciences, Medical University of South Carolina, Charleston, SC, ³Medical University of South Carolina, Charleston, SC, ⁴Department of Medicine, Medical University of South Carolina, Charleston, SC
Background/Purpose: Mesenchymal stem cells (MSCs) are known to possess significant immunosuppressive and tissue protective properties, and their use in refractory systemic lupus erythematosus (SLE) is…
Abstract Number: 2616 • 2017 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Induce CD1c+ Tolerogenic Dendritic Cells Via up-Regulating FLT3L in Systemic Lupus Erythematosus
Xinran Yuan¹, Dandan Wang² and Lingyun Sun³, ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology and immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ³Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital, Nanjing University Medical School, nanjing, China
Background/Purpose: Several tolerogenic dendritic cell (DC) subsets have been identified in human such as CD1c+ DCs, which could be elevated by injection of Flt-3 ligand…
Abstract Number: 1844 • 2016 ACR/ARHP Annual Meeting
Mesenchymal Stem Cells Ameliorate the Deficiencies in Immunomodulatory and Phagocytic Capacities of Lupus Macrophages
Wei Deng¹, Weiwei Chen¹, Zhuoya Zhang², Saisai Huang¹, Wei Kong¹, Xuebing Feng¹ and Lingyun Sun¹, ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Evidence has accumulated that umbilical cord (UC)-derived mesenchymal stem cells (MSCs) show therapeutic effects on systemic lupus erythematosus (SLE). Deficiency in SLE macrophages exhibits…
Abstract Number: 2783 • 2016 ACR/ARHP Annual Meeting
Human Mesenchymal Stem Cells from Different Tissues Exert Distinct Therapeutic Effect on Systemic Lupus Erythematosus
Xiaojun Tang¹, Zhuoya Zhang² and Lingyun Sun¹, ¹Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Previous clinical data has shown that transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) could effectively alleviate the disease symptoms in both patients with…
Abstract Number: 1832 • 2016 ACR/ARHP Annual Meeting
Increased Interferon b Expression in Bone Marrow Mediates a Senescent Phenotype and Impaired Production of Immunomodulatory Factors By SLE Mesenchymal Stromal Cells
Lin Gao¹, Jennifer H. Anolik² and R. John Looney², ¹medicine- allergy, immunology and rheumatology, University of Rochester Medical Center, Rochester, NY, ²Medicine- Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Bone marrow mesenchymal stromal cells (MSCs) are multipotent stem cells that create a special microenvironment for hematopoiesis and immunity. MSCs display robust immunomodulatory properties…
Abstract Number: 2678 • 2014 ACR/ARHP Annual Meeting
UC-MSCs Inhibit T Cell Autophagy and Apoptosis in Patients with Systemic Lupus Erythematosus through Mitochondrial Transfer
Jinyun Chen¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose This study is aimed to investigate the role of umbilical cord derived mesenchymal stem cells (UC-MSCs) on autophagy and apoptosis in T cells from…
Abstract Number: 1938 • 2014 ACR/ARHP Annual Meeting
Effects of Mesenchymal Stem Cells on Human B Cell Proliferation
Erin Collins¹, Maosong Qi² and Gary S. Gilkeson³, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Medicine/ Rheumatology & Immunology, Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Human mesenchymal stem cells (MSC) are progenitor cells that have immunomodulatory properties. MSCs have been used to treat a variety of autoimmune diseases, including…
Abstract Number: 635 • 2014 ACR/ARHP Annual Meeting
Mir-663 Impairs the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on MRL/Lpr Mice
Linyu Geng¹, Xuebing Feng² and Lingyun Sun², ¹The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Previously we have shown that miR-663 was increased in bone marrow derived mesenchymal stem cells (BMSCs) from SLE patients and involved in the functional…
Abstract Number: 2698 • 2013 ACR/ARHP Annual Meeting
The Treg/Th17 Imbalance Of Patients With Systemic Lupus Erythematosus Were Mediated By Mir-663 Through Down-Regulating TGF-β1 Secretion Of Bone Marrow-Derived Mesenchymal Stem Cells
Lingyu Geng¹, Xia Li¹, Xuebing Feng² and Lingyun Sun³, ¹Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ³the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Systemic lupus erythematosus (SLE) patients exist an imbalance between CD4+CD25+FoxP3+ T regulatory (Treg) and IL-17-producing cells (Th17). Correction of this Treg/Th17 imbalance may have…
Abstract Number: 1619 • 2013 ACR/ARHP Annual Meeting
In Vitro Assessments Of Mesenchymal Stem Cells From Lupus Patients To Predict Suppressive Function In Vivo
Erin Collins¹, Fei Gu² and Gary S. Gilkeson³, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology,Medical University of South Carolina, Charleston, SC, ³Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Broad immune suppression by mesenchymal stem cells (MSCs) make them an attractive candidate as a cell therapy for autoimmune diseases, such as systemic lupus…
Abstract Number: 565 • 2013 ACR/ARHP Annual Meeting
Differential Efficacy Of Human Mesenchymal Stem Cells On Disease In Murine Lupus Based On Source Of Origin
Erin Collins¹, Fei Gu², Osama S. Naga¹, Phil Ruiz³ and Gary S. Gilkeson⁴, ¹Medicine/Rheumatology, Medical University of South Carolina, Charleston, SC, ²Division of Rheumatology and Immunology,Medical University of South Carolina, Charleston, SC, ³Pathology, University of Miami, Miami, FL, ⁴Department of Medicine, Division of Rheumatology, Medical University of South Carolina, Charleston, SC
Background/Purpose: Systemic lupus erythematosus (SLE) is a devastating autoimmune disease that targets multiple organ systems. Current treatment options for SLE often cause non-specific immune suppression,…
Abstract Number: 1646 • 2012 ACR/ARHP Annual Meeting
The Mechanism of Umbilical Cord Mesenchymal Stem Cells in the Upregulation of Regulatory T Cells by TGF-β1 in Systemic Lupus Erythematosus
Lingyun Sun¹, Dandan Wang², Lin Lu² and Xia Li², ¹the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ²Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China
Background/Purpose: Umbilical cord (UC) derived mesenchymal stem cells (MSCs) have shown immunoregulation on various immune cells. The aim of this study is to investigate the…

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