Abstracts tagged "mesenchymal stem cells and Senescent Cells"

Abstract Number: 886 • 2019 ACR/ARP Annual Meeting
Mesenchymal Stem Cell Senescence Alleviates Their Chondrogenic and Seno-Suppressive Properties, Contributing to Osteoarthritis Development
Olivier Malaise¹, Yassin Tachikart ², Michael Constantinides ², Marcus Mumme ³, Daniele Noel ², Jing Wang ⁴, Christian Jorgensen ² and Jean-Marc brondello ², ¹GIGA Research, CHU and University of Liège, Liège, Belgium, ²IRMB, INSERM U1183, University of Montpellier, Montpellier, France, ³University Hospital of Basel, Basel, Switzerland, ⁴INM, INSERM U1050, University of Montpellier, Montpeller, France
Background/Purpose: Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders such as osteoarthritis (OA). These senescent cells induce a tissue loss of function through…

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Abstracts tagged "mesenchymal stem cells and Senescent Cells"

Mesenchymal Stem Cell Senescence Alleviates Their Chondrogenic and Seno-Suppressive Properties, Contributing to Osteoarthritis Development