Abstracts tagged "Mesenchymal stem cells and osteoarthritis"

Abstract Number: 850 • 2018 ACR/ARHP Annual Meeting
Long Term Efficacy of Cartilage Repair Induced By scSOX9 in Situ with Bone Marrow-Derived Mesenchymal Stem Cells
Xiaowei Zhang^1,2, Shili Wu³, Yong Zhu³ and Cong-Qiu Chu^4,5, ¹Oregon Health & Science University, Portland, OR, ²VA Portland Health Care System, Portland, OR, ³VivoScript, Inc, Costa Mesa, CA, ⁴Rheumatology, Oregon Health & Science University, Portland, OR, ⁵Rheumatology, VA Portland Health Care System, Portland, OR
Background/Purpose: Microfracture induces fibrocartilage or fibro-hyaline cartilage both are biomechanically inferior to hyaline cartilage. We reported previously that a super positively charged SOX9 (scSOX9) improved…
Abstract Number: 1876 • 2013 ACR/ARHP Annual Meeting
Potential Chondrogenic Biomarkers For Cell-Based Therapy Monitoring In Osteoarthritis
Beatriz Rocha¹, Valentina Calamia², Vanessa Casas³, Lucia Lourido², Carolina Fernandez-Costa², Patricia Fernandez-Puente², Jesus Mateos², Montserrat Carrascal³, Francisco J. Blanco² and Cristina Ruiz-Romero^1,4, ¹Grupo de Proteomica-PBR2-ProteoRed/ISCIII-Servicio de Reumatologia. Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006., A Coruña, Spain, ²Osteoarticular and Aging Research Laboratory, Proteomics Unit-Associated Node to ProteoRed-ISCIII, INIBIC-CHUAC, A Coruña, Spain, ³Laboratorio de Proteómica CSIC/UAB, Barcelona, Spain, ⁴CIBER-BBN, INIBIC-CHUAC, A Coruña, Spain
Background/Purpose: Chondrogenesis occurs as a result of mesenchymal stem cells (MSCs) condensation and chondroprogenitor cell differentiation. Following chondrogenesis, the chondrocytes remain as resting cells to…
Abstract Number: 66 • 2013 ACR/ARHP Annual Meeting
Follistatin-Like Protein 1 Is An Important Regulator Of Chondrogenesis
Yury Chaly¹, Sonja Smith², Daniel Bushnell³, Brian Campfield⁴, Harry Blair⁵ and Raphael Hirsch⁶, ¹Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, ²University of Iowa Carver College of Medicine, Iowa City, IA, ³Division of Pediatric Rheumatology, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁴Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ⁵University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁶Department of Pediatrics,, University of Iowa Carver College of Medicine, Iowa City, IA
Background/Purpose: Chondrocytes play a pivotal role in osteoarthritis (OA) because they are the only cells in the articular cartilage that are responsible for maintenance of…
Abstract Number: 78 • 2013 ACR/ARHP Annual Meeting
Norepinephrine (NE) Inhibits Mesenchymal Stem Cell (MSCs) Chondrogenesis By Accelerating Hypertophy – Relevance For Cartilage Regeneration
Zsuzsa Jenei-Lanzl¹, Peter Angele², Frieder Kees³, Georg Pongratz⁴ and Rainer H. Straub⁵, ¹Department of Internal Medicine, University Hospital Regensburg, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Regensburg, Germany, ²Department of Trauma Surgery, University Hospital Regensburg, Germany, Regensburg, Germany, ³Department of Pharmacology and Toxicology, University of Regensburg, Regensburg, Germany, ⁴Internal Medicine, University Hospital Regensburg, Regensburg, Germany, ⁵Department of Internal Medicine I, Laboratory of Exp. Rheumatology and Neuroendocrino-Immunology, University Hospital of Regensburg, Regensburg, Germany
Background/Purpose: The high potential of mesenchymal stem cells (MSCs) in cartilage regeneration is undoubtful. The presence of MSCs in healthy or arthritic cartilage has also…
Abstract Number: 1006 • 2012 ACR/ARHP Annual Meeting
Dynamic Gene Expression of Wnt Signaling Pathway During Osteogenic Stimulation in Vitro of Osteoarthritis Mesenchymal Stem Cells
A. Peralta-Sastre¹, M. Hernandez-Molinero², P. Tornero-Esteban², E. Villafuertes², B. Fernandez-Gutierrez³ and Jose Ramon Lamas², ¹UGC de Reumatología, 1UGC de Reumatología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain., ²Rheumatology, Hospital Clinico San Carlos, Madrid, Spain, ³Department of Rheumatology, Hospital Clinico San Carlos, Madrid, Spain
Background/Purpose: The role of Wnt signalling in Mesenchymal Stem Cell (MSC) fate is still unclarified. Both, canonical and non-canonical pathways have been implicated in differentiation…
Abstract Number: 48 • 2012 ACR/ARHP Annual Meeting
Tissue Engineering for Articular Cartilage Repair, Culturing Bone Marrow Mesenchymal Stem Cells On Collagen and Heparan Sulphate Scaffolds
Adela Helvia Martinez-Sanchez¹, Clara Sanjurjo-Rodriguez¹, Silvia Diaz-Prado², Emma Muiños¹, Isaac M. Fuentes², Francisco J. De Toro², Julia Bujan³ and Francisco J. Blanco¹, ¹Osteoarticular and Aging Res. Lab. CIBER-BBN. Rheumatology Div. INIBIC-Complejo Hosp. Univ. A Coruña, A Coruña, Spain, ²Osteoarticular and Aging Res. Lab. CIBER-BBN. INIBIC-University of A Coruña, A Coruña, Spain, ³Department of Medical Specialties. University of Alcala de Henares, Madrid, Spain
Background/Purpose: The aim of this study was to evaluate the chondrogenic potential of bone marrow mesenchymal stem cells (BM-MSCs) grown on type I collagen and…
Abstract Number: 50 • 2012 ACR/ARHP Annual Meeting
Human Chondrocyte Dedifferentiation Is Accompagnied by CD105 Endoglin Expression, ALK-1/Smad1/5 Phosphorylation and Leptin Production – Stimulation by Prednisolone and Aldosterone Through the Glucocorticoid Receptor
Olivier Malaise¹, Biserka Relic², Mustapha Zeddou¹, Edith Charlier¹, Florence Quesada Calvo¹, Sophie Neuville³, Dominique de Seny² and Michel G. Malaise⁴, ¹Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, ²Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ³GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, ⁴Department of Rheumatology, University of Liège - CHU Liège, Liège, Belgium
Background/Purpose: Leptin, mainly produced by the adipose tissue including fat neighboring the joint, is considered as pro-inflammatory in osteoarthritis (OA). Normal cartilage does not…
Abstract Number: 7 • 2012 ACR/ARHP Annual Meeting
Lamin A Deregulation in Human Mesenchymal Stem Cells Promotes an Impairment in Their Chondrogenic Potential and Imbalance in Their Response to Oxidative Stress
Jesus Mateos¹, Alexandre De La Fuente², Ivan A. Lesende-Rodriguez², Maria Carmen Arufe² and Francisco J. Blanco¹, ¹Rheumatology Division, Proteomics Unit-ProteoRed/ISCIII, INIBIC-Hospital Universitario A Coruña, A Coruña, Spain, ²Department of Medicine, Area of Anatomy and Human Embryology, University of A Coruña-INIBIC, A Coruña, Spain
Background/Purpose: Previous work by our group and others indicated that an accumulation of lamin A (LMNA) was associated with the osteoarthritis (OA) chondrocyte phenotype. Mutations…
Abstract Number: 22 • 2012 ACR/ARHP Annual Meeting
Protective Properties of Conditioned Media From Adipose Stem Cells On Osteoarthritic Chondrocytes
Maria Isabel Guillén¹, Julia Platas¹, Vicente Mirabet², Miguel Angel Castejón³, Francisco Gomar⁴ and Maria Jose Alcaraz¹, ¹Pharmacology, University of Valencia, Burjasot, Valencia, Spain, ²Generalitat Valenciana, Valencia, Spain, ³De la Ribera University Hospital, Alzira, Spain, ⁴Surgery, University of Valencia and University Hospital, Valencia, Spain
Background/Purpose: Adipose-derived mesenchymal stem cells (ASC) exhibit a high potential for cell therapy and they might also act as a cellular source for supplying soluble…

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