Abstracts tagged "mechanosensing and fibrosis"

Abstract Number: 1056 • 2019 ACR/ARP Annual Meeting
Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway
Tricia Lim¹, Kristina Krogmannova ¹, Shiwen Xu ¹, Bahja Ahmed Abdi ², David Abraham ¹, Christopher Denton ³ and Richard Stratton ¹, ¹University College London, London, United Kingdom, ²University College London, London, ³University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, UK, London, United Kingdom
Background/Purpose: An M2-like alternative activation state of macrophages has been linked to the pathogenesis of several fibrotic disorders, including systemic sclerosis (SSc). MRTF-A is an…

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Abstracts tagged "mechanosensing and fibrosis"

Profibrotic Macrophage Activation in Systemic Sclerosis Is Dependent on the Mechanosensing MRTF-A Pathway