ACR Meeting Abstracts

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Abstracts tagged "mechanisms"

  • Abstract Number: 437 • 2018 ACR/ARHP Annual Meeting

    Does Reduction in Mechanical Knee Joint Loading Explain the Beneficial Effects of Weight Loss in Overweight or Obese Patients with Knee Osteoarthritis?

    Dennis Ang1, Daniel Beavers2 and Stephen P. Messier3, 1Wake Forest University School of Medicine, Winston-Salem, NC, 2Biostatistical Science, Wake Forest School of Medicine, WINSTON SALEM, NC, 3Department of Health and Exerc, Wake Forest University, Winston-Salem, NC

    Background/Purpose: Knee osteoarthritis (KOA) is traditionally considered a local joint pathology. The effect of obesity on the pathogenesis of KOA is predominantly attributed to increase…
  • Abstract Number: 452 • 2018 ACR/ARHP Annual Meeting

    Features of Peripheral and Central Sensitization and Neuropathic Pain Are Seen in Both Osteoarthritis and Rheumatoid Arthritis

    Jacquelin R. Chua1, Shingo Ishihara2, Mariam Riad1, Isabel Castrejón1, Rachel E. Miller3, Anne-Marie Malfait4, Joel A. Block1, Theodore Pincus1 and Najia Shakoor1, 1Division of Rheumatology, Rush University Medical Center, Chicago, IL, 2Internal Medicine, Rush University Medical Center, Chicago, IL, 3Biochemistry, Rush University Medical Center, Chicago, IL, 4Biochemistry & Rheumatology, Rush University Medical Center, Chicago, IL

    Background/Purpose: OA and RA are among the most common chronic painful rheumatic diseases. Appreciation of the role of pain sensitization in OA has revolutionized the…
  • Abstract Number: 628 • 2018 ACR/ARHP Annual Meeting

    Longitudinal Changes in Relative Market Share Proportions of Biologic and Targeted Synthetic Disease-Modifying Anti-Rheumatic Drugs for Treatment of Rheumatoid Arthritis: Descriptive Data from the Ontario Best-Practice Research Initiative Database

    Elliot Hepworth1, Mohammad Movahedi2, Emmanouil Rampakakis3, Reza Mirza1, Arthur Lau4, Angela Cesta5, Janet E. Pope6 and Claire Bombardier7, 1Department of Internal Medicine, McMaster University, Hamilton, ON, Canada, 2JSS Medical Research, St-Laurent, QC, Canada, 3JSS Medical Research, Montreal, QC, Canada, 450 Charlton Avenue East, St Joseph's Healthcare Hamilton, Hamilton, ON, Canada, 5Ontario Best Practices Research Initiative, University Health Network, Toronto, ON, Canada, 6Department of Medicine, University of Western Ontario, London, ON, Canada, 7Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada

    Background/Purpose: For patients with Rheumatoid Arthritis (RA) who do not achieve adequate clinical response with combined conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs), the next…
  • Abstract Number: 1109 • 2018 ACR/ARHP Annual Meeting

    Gene Expressions of TMEM176A and TMEM176B Were Prominent at the Stage of Subclinical Pulmonary Vascular Disease in Systemic Sclerosis

    Yoshinobu Koyama1, Soichiro Fuke2, Takashi Ohno3, Yoshiharu Sato4 and Toshie Higuchi1, 1Center for Autoimmune Diseases, Division of Rheumatology, Japan Red Cross Okayama Hospital, Okayama, Japan, 2Department of Cardiology, Japan Red Cross Okayama Hospital, Okayama, Japan, 3Management of medical safety, Okayama University Hospital, Okayama, Japan, 4DNA Chip Research Inc, Tokyo, Japan

    Background/Purpose: Pulmonary arterial hypertension (PAH) is prominent as a vascular involvement of systemic sclerosis (SSc), which remains a leading cause of death in spite of…
  • Abstract Number: 2589 • 2017 ACR/ARHP Annual Meeting

    Functional and Mechanistic Characterization of Anifrolumab, a Fully Human Monoclonal Antibody Targeting the Interferon Alpha Receptor 1 for the Treatment of SLE

    Gary P. Sims1, Jeffrey Riggs2, Richard Hanna1, Bhargavi Rajan3, Jodi Karnell1, Kamelia Zerrouki1, Divya Sagar1, Inna Vainshtein3, Erika Farmer4, Meina Liang3, Miguel A. Sanjuan1 and Roland Kolbeck1, 1Respiratory, Inflammation and Autoimmunity (RIA), MedImmune, LLC, Gaithersburg, MD, 2Respiratory, Inflammation and Autoimmunity (RIA), MedImmune LLC, Gaithersburg, MD, 3MedImmune, LLC, Mountain View, CA, 4Analytical Sciences, MedImmune, LLC, Gaithersburg, MD

    Background/Purpose: Increased type I interferon (IFN) activity is associated with the pathogenesis of SLE. Anifrolumab, a fully human immunoglobulin (Ig) G1 κ monoclonal antibody in clinical…
  • Abstract Number: 1989 • 2016 ACR/ARHP Annual Meeting

    Mechanism of STAT3 Gain-of-Function in a Patient with JIA

    Tiphanie P. Vogel1,2, Nermina Saucier3, Molly P. Keppel3 and Megan A. Cooper3,4, 1Pediatrics/Rheumatology, Washington University in St. Louis, St. Louis, MO, 2Internal Medicine/Rheumatology, Washington University in St. Louis, Saint Louis, MO, 3Pediatrics/Rheumatology, Washington University in St. Louis, Saint Louis, MO, 4Pathology and Immunology, Washington University in St. Louis, Saint Louis, MO

    Background/Purpose:  The transcription factor signal transducer and activator of transcription 3 (STAT3) mediates cytokine-induced changes in gene expression. STAT3 is classically activated by phosphorylation followed…
  • Abstract Number: 1805 • 2015 ACR/ARHP Annual Meeting

    Functional and Mechanistic Characterization of Anifrolumab, a Fully Human, Anti-IFNAR1 Monoclonal Antibody for the Treatment of Systemic Lupus Erythematosus

    Jeffrey Riggs1, Brian Naiman2, Jing Zhang1, Yan Xu1, Inna Vainshtein3, Carl Hay1, Kevin Schifferli1, Pina Cardarelli4, Meina Liang5, Lorin Roskos6, Jane Connor7, Roland Kolbeck8, Anthony Coyle9 and Michael Fung1, 1MedImmune LLC, Gaithersburg, MD, 2Research, MedImmune LLC, Gaithersburg, MD, 3MedImmune LLC, Hayward, CA, 4Medarex, Sunnyvale, CA, 5PKPD&Bioanalysis, MedImmune LLC, Hayward, CA, 6MedImmune LLC, Mountain View, CA, 7Respiratory, Inflammation and Autoimmunity (RIA), MedImmune LLC, Gaithersburg, MD, 8Department of Respiratory, Inflammation and Autoimmunity, MedImmune LLC, Gaithersburg, MD, 9Centers for Therapeutic Innovation, Pfizer, Inc. (formerly MedImmune LLC, Gaithersburg, MD, USA), Cambridge, MA

    Background/Purpose: Increased type I interferon (IFN) activities are associated with the pathogenesis of systemic lupus erythematosus (SLE). Anifrolumab, a fully human, IgG1 κ monoclonal antibody…
  • Abstract Number: 2605 • 2015 ACR/ARHP Annual Meeting

    14-3-3η Positive Status and Higher Titres Are Associated with More Severe RA

    Shintaro Hirata1, Kentaro Hanami2, Anthony Marotta3 and Yoshiya Tanaka4, 1The First Department of Internal Medicine, University of Occupational & Environmental Health, Japan, Kitakyushu, Japan, 2The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 3Augurex Life Sciences Corp., Vancouver, BC, Canada, 4The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

    Background/Purpose: Serum 14-3-3η is an RA diagnostic marker that is associated with radiographic progression risk. In vitro studies describe 14-3-3η's potent, dose-dependent up-regulation of factors…
  • Abstract Number: 1972 • 2014 ACR/ARHP Annual Meeting

    Analysis of Anakinra in Primary Human Cell Systems Reveals an in Vitro Signature for Skin-Related Side Effects

    Ellen L. Berg, Alison O'Mahony and Mark A Polokoff, BioSeek, South San Francisco, CA

    Background/Purpose The therapeutic options for treatment of rheumatic diseases have grown and now include a variety of inflammatory pathway inhibitors, with diverse mechanisms, but having…
  • Abstract Number: 2567 • 2013 ACR/ARHP Annual Meeting

    Cadherin-11 Regulates Pulmonary Fibrosis In Bleomycin-Induced Lung Injury

    Mesias Pedroza, Anuh T. George and Sandeep K. Agarwal, Medicine, Section of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Houston, TX

    Background/Purpose: Pulmonary fibrosis (PF) is the leading cause of death in systemic sclerosis.  Pathologically, PF is characterized by an aberrant wound healing repair mechanism leading…
  • Abstract Number: 2218 • 2013 ACR/ARHP Annual Meeting

    Gingival Stem Cells Suppress Osteoclast Formation and Bone Erosion In CIA Through CD39 Signal

    Song Guo Zheng1, Jian Gu2, Maogeng Chen1 and Yi Shen3, 1Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, 2Medcine, University of Southern California Keck School of Medicine, Los Angeles, CA, 3Medicine, Shanghai East Hospital at Tongji University, Shanghai, China

    Background/Purpose: We recently have reported that human-derived gingival mesenchymal stem cells (GMSC) have strong capacity to suppress immune responses and T cell-mediated collagen-induced arthritis, however,…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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