Abstracts tagged "matrix metalloproteinase (MMP) and mesenchymal stem cells"

Abstract Number: 2993 • 2016 ACR/ARHP Annual Meeting
Membrane-Type 1 Matrix Metalloproteinase Controls Osteo- and Chondrogenesis By a Proteolysis-Independent Mechanism Mediated By Its Cytoplasmic Tail
Yang Qing¹, Mukundan Attur², Thorsten Kirsch³, You Jin Lee³, Shoshana Yakar⁴, Zhomgbo Liu⁵, Steven B. Abramson⁶ and Paolo Mignatti⁷, ¹Medicine, New York University School of Medicine, New York, NY, ²Rheumatology Research, NYU - Hospital for Joint Diseases, New York, NY, ³Orthopaedic Surgery, New York University, New York, NY, ⁴Basic Science and Craniofacial Biology, College of Dentistry, New York University, New York, NY, ⁵New York University, New York, NY, ⁶Dept of Rheumatology/Medicine, Hosp for Joint Diseases/NYU, New York, NY, ⁷Medicine, New York University, New York, NY
Background/Purpose: We aimed to understand the mechanism by which membrane-type 1 matrix metalloproteinase (MT1-MMP, MMP-14) controls bone and cartilage homeostasis. MT1-MMP, a cell-membrane-bound proteinase with…

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