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Abstracts tagged "mast cells and vasculitis"

  • Abstract Number: 788 • ACR/ARHP Annual Meeting 2017

    Mast Cell Mediated Inhibition of Systemic IL-6 in candida Albicans Water-Soluble Fraction (CAWS) Induced Model of Large Vessel Vasculitis

    Mingcai Zhang1, Mehrdad Maz2, Don Smith3, Noriko Miura4, Naohito Ohno5, Kottarappat Dileepan6 and Jason Springer7, 1Department of Orthopedics, University of Kansas Medical Center, Kansas City, KS, 2Allergy, Clinical Immunology, and Rheumatology, Division of Allergy, Clinical Immunology and Rheumatology, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, 3University of Kansas Medical Center, Kansas City, KS, 4School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan, 5Tokyo University of Pharmacy and Lift Sciences, Tokyo, Japan, 6Department of Medicine, University of Kansas Medical Center, Kansas, KS, 7Department of Internal Medicine, Division of Allergy, Clinical Immunology, & Rheumatology, Kansas University Medical Center, Kansas City, KS

    Background/Purpose: In forms of large vessel vasculitis (LVV) systemic IL-6 has been shown to follow disease activity. Furthermore, IL-6 inhibition is an effective treatment for…
  • Abstract Number: 200 • ACR/ARHP Annual Meeting 2015

    Mast Cell Regulation of Aortic IL-6 Expression Involves Histamine-1 Receptor, Suppressor of Cyotkine Signaling-1 and IL-10

    Vineesh Raveendran1, Jason Springer2, Donald Smith3, Mehrdad Maz4 and Kottarappat Dileepan1, 1Department of Medicine, University of Kansas Medical Center, Kansas City, KS, 2Division of Allergy, Clinical Immunology and Rheumatology, University of Kansas Medical Center, Kansas City, KS, 3University of Kansas Medical Center, Kansas City, KS, 4Division of Rheumatology, University of Kansas Medical Center, Kansas City, KS

    Background/Purpose: IL-6 plays an important role in the pathogenesis of large vessel vasculitis.  Lipopolysaccharide (LPS), acting through toll-like receptor 4, enhances both the aortic expression…

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