Abstracts tagged "MALT lymphoma"

Abstract Number: 2432 • 2019 ACR/ARP Annual Meeting
Thymic Stromal Lymphopoietin (TSLP) as a Biomarker of Primary Sjögren’s Syndrome (pSS) and Related Lymphoma: Results in Independent Cohorts
Saviana Gandolfo¹, Cinzia Fabro ¹, Serena Colafrancesco ², Francesco Carubbi ³, Francesco Ferro ⁴, Elena Bartoloni ⁵, Efstathia Kapsogeorgou ⁶, Andreas Goules ⁶, Luca Quartuccio ¹, Roberta Priori ², Alessia Alunno ⁵, Guido Valesini ², Roberto Giacomelli ³, Roberto Gerli ⁵, Chiara Baldini ⁴, Athanasios Tzioufas ⁶ and Salvatore De Vita ¹, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ²Rheumatology Unit, Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Rome, Italy, Roma, Italy, ³Rheumatology Unit, Department of Biotechnological and Applied Clinical Science, School of Medicine, University of L'Aquila, L'Aquila, Italy, L'Aquila, Italy, ⁴Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ⁵Rheumatology Unit, Department of Medicine, University of Perugia, Perugia, Italy, Perugia, Italy, ⁶Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece
Background/Purpose: Thymic stromal lymphopoietin (TSLP) has been implicated in primary Sjögren’s syndrome (pSS) and related B-cell lymphoproliferation / lymphoma (NHL) by tissue studies on salivary…
Abstract Number: 2433 • 2019 ACR/ARP Annual Meeting
Fatigue in Primary Sjögren’s Syndrome as a Manifestation of Heavier Disease Activity of Mucosa-Associated Lymphoid Tissue (MALT)
Saviana Gandolfo¹, Marco Binutti ¹, Elena Doriguzzi Breatta ¹, Cinzia Fabro ¹ and Salvatore De Vita ¹, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy
Background/Purpose: Fatigue is one of the most prevalent and impacting symptoms in primary Sjögren’s syndrome (pSS), significantly impairing the patient quality of life. To date,…
Abstract Number: 2436 • 2019 ACR/ARP Annual Meeting
The Salivary Glands as the Key Site of Inflammation and Lymphoproliferation Leading to Lymphoma in Primary Sjögren’s Syndrome: Relevance for Dedicated Scoring, Biomarker Development and Lymphoma Prevention
Salvatore De Vita¹, Saviana Gandolfo ¹, Chiara Baldini ², Miriam Isola ³, Michael Voulgarelis ⁴, Andreas Goules ⁴, Ginevra De Marchi ⁵, Marco Binutti ¹, Sara Zandonella Callegher ⁵, Francesco Ferro ², Claudio Battistella ³, Loukas Chatzis ⁴ and Athanasios Tzioufas ⁴, ¹Rheumatology Clinic, Udine University Hospital, Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ²Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy, Pisa, Italy, ³Department of Medical Area, University of Udine, Udine, Italy, Udine, Italy, ⁴Department of Pathophysiology, Athens School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece, ⁵Rheumatology Clinic, Udine University Hospital, Udine, Italy, Udine, Italy
Background/Purpose: Since the risk of B-cell non-Hodgkin’s lymphoma (NHL) evolution is increased in primary Sjögren’s syndrome (pSS), its prevention represents a relevant therapeutic end-point. A…
Abstract Number: 3075 • 2015 ACR/ARHP Annual Meeting
Salivary Gland FcRL4+ B-Cells Are a Potential Source of Progenitor Cells for MALT Lymphoma in Primary Sjögren’s Syndrome
Erlin A. Haacke¹, Frans G.M. Kroese², Philip Kluin³, Petra M. Meiners⁴, Annie Visser⁵, Fred K.L. Spijkervet⁶ and Hendrika Bootsma⁷, ¹Pathology, University Medical Center Groningen, Groningen, Netherlands, ²Rheumatology and Clinical Immunology, University Medical Center Groningen, Groningen, Netherlands, ³Department of Pathology and Medical Biology, UMCG Groningen, Groningen, Netherlands, ⁴Oral and Maxillofacial Surgery, University Medical Center Groningen, University of Groningen, Groningen, Netherlands, ⁵Rheumatology and Clinical Immunology, UMC Groningen, Groningen, Netherlands, ⁶Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, Netherlands, ⁷Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands
Background/Purpose: Patients with primary Sjögren's Syndrome (pSS) have an increased risk of non-Hodgkin's lymphoma, predominantly of the Mucosa Associated Lymphoid Tissue (MALT) type, which commonly…
Abstract Number: 637 • 2015 ACR/ARHP Annual Meeting
Repeated B Lymphocyte Depletion Therapy with Rituximab in Sjögren’s Syndrome: A Single Center Experience
Francesco Ferro¹, Chiara Baldini¹, Nicoletta Luciano¹, Maurizio Mazzantini¹, Daniela Martini¹, Sara Galimberti², Valentina Donati³, Marta Mosca⁴ and Stefano Bombardieri¹, ¹Rheumatology Unit, University of Pisa, Italy, Pisa, Italy, ²Hematology Unit, University of Pisa, Italy, Pisa, Italy, ³Department of Pathology, AOUP, Pisa, Italy, Pisa, Italy, ⁴University of Pisa, Pisa, Italy
Background/Purpose: Recent insights from open studies and randomized clinical trials have shown the effectiveness of Rituximab (RTX) in controlling disease activity, patients’ subjective symptoms and…
Abstract Number: 644 • 2015 ACR/ARHP Annual Meeting
Predicting the Risk for Lymphoma Development in Sjögren’s Syndrome: An Easy to Use Clinical Tool
Sofia Fragkioudaki¹, Clio Mavragani² and Haralampos M. Moutsopoulos³, ¹Physiology, Medical School of Athens, Department of Physiology, Athens, Greece, ²Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece
Background/Purpose: Studies from our and other laboratories have shown that clinical, laboratory and serological features at the first evaluation of a patient with primary Sjogren’s…
Abstract Number: 2791 • 2015 ACR/ARHP Annual Meeting
TREX-1 Variants in Sjögren’s Syndrome Related Lymphomagenesis
Panagiota Makri¹, Adrianos Nezos², Michael Voulgarelis³, Haralampos M. Moutsopoulos⁴ and Clio Mavragani⁵, ¹Physiology, Department of Physiology, School of Medicine, University of Athens, Athens, Greece, ²Physiology, Department of Experimental Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece, ³Pathophysiology, Department of Pathophysiology, Medical School of Athens, Athens, Greece, ⁴Department of Pathophysiology, Medical School of Athens, Department of Pathophysiology, Athens, Greece, ⁵Physiology, Department of Physiology, School of Medicine, National Kapodistrian University of Athens, Athens, Greece
Background/Purpose: Three prime Repair Exonuclease 1 (TREX-1) is an exonuclease involved in DNA repair preventing genomic instability. TREX-1 variants have been previously associated with activation of type…
Abstract Number: 2538 • 2014 ACR/ARHP Annual Meeting
Ultrasound-Guided Core Needle Biopsy of the Major Salivary Glands Is a Safe and Useful Diagnostic Tool in the Evaluation of Suspected or Established Sjögren’s Syndrome
Anand Narayan¹, Thomas Grader-Beck², Julius Birnbaum³, Jean Kim⁴, Qing Kay Li⁵, Deborah Belchis⁵, Joel Fradin¹ and Alan N. Baer⁶, ¹Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, ²Medicine Div of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ³Department of Medicine, Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁴Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ⁵Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, ⁶Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: Ultrasound-guided core needle biopsy (CNB) has greater inherent risks than fine-needle aspiration for the diagnosis of major salivary gland neoplasms, but provides tissue for…

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