ACR Meeting Abstracts

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Abstracts tagged "major histocompatibility complex (MHC) and rheumatoid arthritis (RA)"

  • Abstract Number: 76 • 2018 ACR/ARHP Annual Meeting

    Whole Blood Targeted Bisulfite Pyrosequencing Identifies Differentially Methylated Regions within Major Histocompatibility Complex (MHC) of Patients with Rheumatoid Arthritis

    Vidyanand Anaparti1, Irene Smolik2, Prasoon Agarwal3, Neeloffer Mookherjee1 and Hani El-Gabalawy4, 1Internal Medicine, University of Manitoba, Winnipeg, MB, Canada, 2Food and Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada, 3Physiology and Pathophysiology, University of Manitoba, Winnipeg, MB, Canada, 4University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Human major histocompatibility complex (MHC) is strongly associated with rheumatoid arthritis (RA) pathogenesis. Epigenome-wide association study by Liu et al showed that differential DNA…
  • Abstract Number: 1573 • 2016 ACR/ARHP Annual Meeting

    Major Histocompatibility Antigen HLA-DQ6.1 (DQA1*0103/DQB1*0601) Increases Rheumatoid Arthritis Risk Independent of Shared Epitope Among Indians

    Able Lawrence1, Swayam Prakash2, Uddalak Bharadwaj3, Amita Aggarwal4, Ramnath Misra4 and Suraksha Agrawal2, 1Clinical Immunology, SGPGIMS, Lucknow, India, 2Medical Genetics, SGPGIMS, Lucknow, India, 3MD Anderson Cancer Center, Houston, TX, 4Clinical Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

    Background/Purpose: The association of HLA-DRB1 shared epitope (SE) with rheumatoid arthritis (RA) does not completely explain MHC association. The HLA-DRB1 alleles are classified into high…
  • Abstract Number: 1919 • 2016 ACR/ARHP Annual Meeting

    Analysis of T Cell Repertoire Diversity of CD4+ Memory and NaïVe T Cells By Next Generation Sequencing and Its Association with Rheumatoid Arthritis Disease Parameters

    Keiichi Sakurai1, Hirofumi Shoda1, Kazuyoshi Ishigaki2, Yumi Tsuchida1, Yasuo Nagafuchi1, Shuji Sumitomo1, Akari Suzuki2, Keishi Fujio1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan

    Background/Purpose:  Rheumatoid arthritis (RA) is an autoimmune disease characterized by peripheral polyarthritis. The importance of CD4+ T cell in the pathophysiology of RA is well-known…
  • Abstract Number: 2035 • 2016 ACR/ARHP Annual Meeting

    Dosage Contribution of a Non-Classical HLA Gene, HLA-Doa, to the Risk of Rheumatoid Arthritis

    Yukinori Okada1, Akari Suzuki2, Katsunori Ikari3, Chikashi Terao4, Yuta Kochi2, Koichiro Ohmura5, Koichiro Higasa5, Masato Akiyama2, Kyoto Ashikawa2, Masahiro Kanai2, Jun Hirata1, Naomasa Suita1, Yik-Ying Teo6, Huji Xu7, Sang-Cheol Bae8, Yukihide Momozawa2, koichi Matsuda9, Shigeki Momohara10, Atsuo Taniguchi10, Ryo Yamada5, Tsuneyo Mimori5, Michiaki Kubo2, Matthew A. Brown11, Soumya Raychaudhuri12, Fumihiko Matsuda5, Hisashi Yamanaka10, Yoichiro Kamatani2 and Kazuhiko Yamamoto9, 1Osaka University, Osaka, Japan, 2Center for Integrative Medical Sciences, RIKEN, Yokohama, Japan, 3Inst of Rheumatology, Tokyo Women's Medical University, Tokyo, Japan, 4Departments of Genetics and Rheumatology, Brigham and Women'’s Hospital, Harvard Medical School, Boston, MA, 5Kyoto University Graduate School of Medicine, Kyoto, Japan, 6Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore, 7The Second Military Medical University, Shanghai, Japan, 8Hanyang University Hospital for Rheumatic Diseases, Seoul, Korea, The Republic of, 9The University of Tokyo, Tokyo, Japan, 10Tokyo Women's Medical University, Tokyo, Japan, 11The University of Queensland Diamantina Institute, Brisbane, Australia, 12Brigham and Women's Hospital, Boston, MA

    Background/Purpose: Despite the progress in human leukocyte antigen (HLA) causal variant mapping, independent localization of major histocompatibility complex (MHC) risk from classical HLA genes is…
  • Abstract Number: 2918 • 2014 ACR/ARHP Annual Meeting

    Fine-Mapping Major Histocompatibility Complex Associations in ACPA-Positive Rheumatoid Arthritis Identified Shared HLA Amino Acid Polymorphisms in Asian and European Populations

    Yukinori Okada1, Kwangwoo Kim2, Buhm Han3, Nisha E. Pillai4, Rick T-H. Ong4, Woei-Yuh Saw4, Ma Luo5, Lei Jiang6, Jian Yin6, So-Young Bang7, Hye-Soon Lee7, Matthew A. Brown8, Sang-Cheol Bae2, Huji Xu9, Yik-Ying Teo4, Paul IW. de Bakker10 and Soumya Raychaudhuri3, 1Department of Human Genetics and Disease Diversity, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan, 2Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 4National University of Singapore, Singapore, Singapore, 5University of Manitoba, Winnipeg, MB, Canada, 6The Second Military Medical University, Shanghai, China, 7Department of Rheumatology, Hanyang University Guri Hospital, Guri, South Korea, 8University of Queensland Diamantina Institute, Brisbane, Australia, 9Shanghai Changzheng Hospital, Shanghai, China, 10Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands

    Background/Purpose: Rheumatoid arthritis (RA) risk is strongly associated with variations within the major histocompatibility complex (MHC) region, and in particular to HLA-DRB1 alleles. We aimed…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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