Abstracts tagged "major histocompatibility complex (MHC) and methylation"

Abstract Number: 1080 • 2018 ACR/ARHP Annual Meeting
Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T Cells Is Associated with Type-I Interferon-Dependent HLA-DRB1 Overexpression and Activation of Autologous CD4+ T Cells in Systemic Lupus Erythematosus
Shaylynn Miller¹, Patrick Coit¹, Elizabeth Gensterblum-Miller¹, Paul Renauer^1,2, Nathan Kilian^1,3, Mark Schonfeld¹, Pei-Suen Tsou¹ and Amr H Sawalha¹, ¹Division of Rheumatology, University of Michigan, Ann Arbor, MI, ²Department of Genetics, Yale University, New Haven, CT, ³Medical School, Georgetown University, Washington, DC
Background/Purpose: Systemic lupus erythematosus is a chronic autoimmune disease characterized by epigenetic dysregulation, and increased autoantibody and type-I interferon (IFN) production. The goal of this…

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Abstracts tagged "major histocompatibility complex (MHC) and methylation"

Hypomethylation of STAT1 and HLA-DRB1 in CD8+ T Cells Is Associated with Type-I Interferon-Dependent HLA-DRB1 Overexpression and Activation of Autologous CD4+ T Cells in Systemic Lupus Erythematosus