Abstracts tagged "Magnetic resonance imaging (MRI)"

Abstract Number: 1124 • 2012 ACR/ARHP Annual Meeting
Total Knee Replacement As an Osteoarthritis Study Outcome: Predictors Derived From Long-Term Observation Following a Randomized Clinical Trial
Jean-Pierre Raynauld¹, Johanne Martel-Pelletier¹, Marc Dorais², Boulos Haraoui¹, Denis Choquette¹, François Abram³, André Beaulieu⁴, Louis Bessette⁵, Frédéric Morin⁶, Lukas M. Wildi¹ and Jean Pierre Pelletier⁷, ¹Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, QC, Canada, ²StatSciences Inc., Notre-Dame de l’Île Perrot, QC, Canada, ³Medical Imaging Research & Development, ArthroLab Inc., Montreal, QC, Canada, ⁴Faculty of Medicine, Laval University, Quebec, QC, Canada, ⁵Centre Hospitalier Universitaire de Québec, pavillon CHUL, Sainte-Foy, QC, Canada, ⁶Centre de Recherche Musculo-squelettique, Trois-Rivières, QC, Canada, ⁷Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, Canada
Background/Purpose: Using data from a 4-year follow-up of knee OA patients who formerly received treatment with chondroitin sulfate (CS) within a 6-month clinical trial, we…
Abstract Number: 806 • 2012 ACR/ARHP Annual Meeting
Posterior Insula Combined Glutamate and Glutamine Is Associated with Pain in Fibromyalgia: A Replication Study
Eric Ichesco¹, Daniel J. Clauw², Steven E. Harte¹, Anson E. Kairys³, Johnson P. Hampson¹, Tobias Schmidt-Wilcke¹ and Richard E. Harris¹, ¹Anesthesiology, University of Michigan, Ann Arbor, MI, ²Anesthesiology/Internal Medicine (Rheum), University of Michigan, Ann Arbor, MI, ³Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan, Ann Arbor, MI
Background/Purpose: Central pain augmentation resulting from enhanced excitatory and/or decreased inhibitory neurotransmission is a proposed mechanism underlying the pathophysiology of functional pain syndromes such as…
Abstract Number: 1131 • 2012 ACR/ARHP Annual Meeting
Intraarticular Infliximab for Knee Osteoarthritis: High Baseline Levels of Synovial Cellularity and High MRI Cartilage Injury At the Lateral Tibial Plateau Predict Improvement in Total WOMAC Score
Jeremy R. Schue¹, Ossama Tawfik², Rebecca Bolce³, Donald D. Smith¹, Gary Hinson⁴, Jo A. Wick⁵ and Herbert B. Lindsley⁶, ¹Internal Medicine, Kansas University Med Ctr, Kansas City, KS, ²Pathology, Kansas University Med Ctr, Kansas City, KS, ³Crescendo Bioscience Inc., South San Francisco, CA, ⁴Radiology, Kansas University Med Ctr, Kansas City, KS, ⁵Biostatistics, Kansas University Med Ctr, Kansas City, KS, ⁶Medicine, Kansas University Med Ctr, Kansas City, KS
Background/Purpose: Synovial tissue from patients with OA often demonstrates inflammation. We hypothesized that a single intraarticular (IA) injection of an anti-TNF drug would decrease inflammatory…
Abstract Number: 721 • 2012 ACR/ARHP Annual Meeting
Measurement of Pulmonary Arteries by Cardiac Magnetic Resonance Imaging: A Simple and Useful Tool for the Detection of Pulmonary Hypertension in Systemic Sclerosis Patients without Overt Cardiac Microvascular Perfusion Defects or Fibrosis
Sandra Chartrand¹, Lada Miller¹, Martial Koenig², Jean-Richard Goulet¹, Eric Rich¹, Anne S. Chin³, Yves Provost³, Carl Chartrand-Lefebvre³, Pauline Gou¹, Jean-Luc Senécal¹ and Tamara Grodzicky¹, ¹Rheumatology, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ²Internal Medicine, Hôpital Notre-Dame du CHUM, Montréal, QC, Canada, ³Radiology, Hôtel-Dieu de Montréal du CHUM, Montréal, QC, Canada
Background/Purpose: Pulmonary hypertension (PH) is a major complication of systemic sclerosis (SSc). We observed that a significant proportion of our SSc patients with PH as…
Abstract Number: 2534 • 2012 ACR/ARHP Annual Meeting
The Intensive Diet and Exercise for Arthritis Trial (IDEA): 18-Month Radiographic and MRI Outcomes
David J. Hunter¹, D. Beavers², Felix Eckstein³, Ali Guermazi⁴, Richard F. Loeser⁵, Barbara J. Nicklas⁶, Shannon Mihalko⁷, Gary D. Miller⁷, Mary Lyles⁸, Paul DeVita⁹, Claudine Legault¹⁰, J. Jeffery Carr¹¹, Jeff D. Williamson⁸ and Stephen P. Messier⁷, ¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ²Wake Forest University, Winston Salem, NC, ³Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ⁴Radiology, Boston University, Boston, MA, ⁵Section Of Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, NC, ⁶Center on Aging, Wake Forest University School of Medicine, Winston-Salem, NC, ⁷Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC, ⁸Center on Aging, Wake Forest University School of Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, ⁹Department of Exercise and Sport Science, East Carolina University, Greenville, NC, ¹⁰Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, ¹¹Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, NC
Background/Purpose: Dietary induced weight loss is a proven non-pharmacologic intervention for osteoarthritis. Based upon current literature it is unclear if weight loss modifies structural progression.…
Abstract Number: 1103 • 2012 ACR/ARHP Annual Meeting
Cumulative Occupational Physical Load As Risk Factor for Knee Osteoarthritis
Allison M. Ezzat¹, Jolanda Cibere², Mieke Koehoorn³, Eric C. Sayre⁴ and Linda C. Li⁵, ¹School of Rehabilitation Science, University of British Columbia, Vancouver, BC, Canada, ²Division of Rheumatology, Arthritis Research Centre of Canada, Richmond, BC, Canada, ³University of British Columbia, Vancouver, BC, Canada, ⁴Arthritis Research Centre of Canada, Vancouver, BC, Canada, ⁵Department of Physical Therapy, University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Knee osteoarthritis (OA) results from the interaction of multiple risk factors, one of which may be physically demanding occupations. The purpose of this study…
Abstract Number: 611 • 2012 ACR/ARHP Annual Meeting
Impaired Diffusion Tensor Imaging Findings in the Corpus Callosum and Cingulum May Underlie Impaired Learning and Memory Abilities in Systemic Lupus Erythematosus
Daphna Paran¹, Elissa Ash², Ira Litinsky¹, Valerie Aloush¹, Marina Anouk¹, Dan Caspi³, Talma Hendler⁴ and Irit Shapira-Lichter⁴, ¹Rheumatology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel, ²Neurology, Tel Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel, ³Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, ⁴Functional Brain Center, Wohl Institute for Advanced Imaging, Tel-Aviv Sourasky Medical Ctr, Tel-Aviv University, Tel Aviv, Israel
Background/Purpose: Memory impairment is prevalent in systemic lupus erythematosus (SLE), however the pathogenesis is unknown. In a previous functional Magnetic Resonance Imaging (MRI) study we…
Abstract Number: 2538 • 2012 ACR/ARHP Annual Meeting
The Association of Fat Mass and Skeletal Muscle Mass with Clinical and Structural Knee Osteoarthritis: The Netherlands Epidemiology of Obesity Study
A. Willemien Visser¹, Marieke Loef¹, Martin den Heijer², Monique Reijnierse³, Frits R. Rosendaal² and Margreet Kloppenburg⁴, ¹Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ²Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands, ³Radiology, Leiden University Medical Center, Leiden, Netherlands, ⁴Rheumatology and Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Body mass index (BMI) is an important risk factor for knee osteoarthritis (OA), but BMI depends only upon height and weight and gives no…
Abstract Number: 1111 • 2012 ACR/ARHP Annual Meeting
Erosive Evolution in Hand Osteoarthritis Is Associated with Incident Joint Tenderness Independent of MRI-Defined Bone Marrow Lesions and Synovitis
Ida K. Haugen¹, Barbara Slatkowsky-Christensen¹, Pernille Boyesen¹, Sølve Sesseng², Désirée van der Heijde³ and Tore K. Kvien⁴, ¹Rheumatology, Diakonhjemmet Hospital, Oslo, Norway, ²Radiology, Diakonhjemmet Hospital, Oslo, Norway, ³Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁴Dept. of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Previous studies have shown no association between increased amount of radiographic hand osteoarthritis (OA) resulting in more hand pain/disabilities. In this longitudinal study, our…
Abstract Number: 571 • 2012 ACR/ARHP Annual Meeting
Description of Distribution of Active Inflammatory Lesions On Magnetic Resonance Imaging of the Sacroiliac Joints and the Spine in Patients with Early Axial Spondyloarthritis – Analysis of the Esther Trial Baseline Data
In-Ho Song¹, Christian Althoff², Hildrun Haibel¹, Joachim Listing³, Anja Weiß⁴, Bruce Freundlich⁵, Martin Rudwaleit⁶ and Joachim Sieper⁷, ¹Medical Department I, Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany, ²Radiology, Charite Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, ³German Rheumatism Research Center, Berlin, Germany, ⁴German Rheumatism Research Centre, Berlin, Germany, ⁵University of Pennsylvania, Philadelphia, PA, ⁶Endokrinologikum Berlin, Berlin, Germany, ⁷Medical Department I, Rheumatology, Charité Universitätesmedizin Berlin, Berlin, Germany
Background/Purpose: To address the question whether active inflammation starts at specific sites of the sacroiliac joints (SI-joints) and/ or the spine. Methods: Wb-MRIs of…
Abstract Number: 2512 • 2012 ACR/ARHP Annual Meeting
Changes in Bone Marrow Lesion Volume Relate to Changes in Knee Pain. Data From the Osteoarthritis Initiative
Jeffrey B. Driban¹, Lori Lyn Price², Grace H. Lo³, Jincheng Pang⁴, Eric Miller⁴, Charles Eaton⁵, John A. Lynch⁶ and Timothy E. McAlindon⁷, ¹Rheumatology, Tufts Medical Center, Boston, MA, ²Biostatistics Research Center, Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA, ³Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX, ⁴Department of Electrical and Computer Engineering, Tufts University, Medford, MA, ⁵Center for Primary Care and Prevention, Memorial Hospital of Rhode Island, Providence, RI, ⁶Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA, ⁷Division of Rheumatology, Tufts Medical Center, Boston, MA
Background/Purpose: Changes in bone marrow lesions (BMLs), common magnetic resonance (MR) imaging findings in osteoarthritis (OA), are predictive of OA progression. However, it is unclear…
Abstract Number: 1040 • 2012 ACR/ARHP Annual Meeting
Combined High-Resolution Single Photon Emission Computed Tomography and Magnetic Resonance Imaging for Therapy Monitoring in Rheumatoid Arthritis
Philipp Sewerin¹, Christian Buchbender², Katalin Mattes-György³, Falk Miese², Hans-Jörg Wittsack², Christof Specker⁴, Gerald Antoch², Matthias Schneider⁵, Axel Scherer² and Ben Ostendorf¹, ¹Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany, ²Diagnostic and Interventional Radiology, Heinrich-Heine-University, Düsseldorf, Germany, ³Nuclear Medicine, Heinrich-Heine-University, Düsseldorf, Germany, ⁴Department of rheumatology and clinical immunology, Hospital Essen Sued, Essem, Germany, ⁵Endocrinology, Diabetology and Rheumatology, Heinrich-Heine-University, Duesseldorf, Germany
Background/Purpose: To evaluate whether combined multi-pinhole single photon emission computed tomography (MPH-SPECT) with technetium-99m-labelled disphosphonates (Tc99m-DPD) and magnetic resonance imaging (MRI) detect changes in inflammation…
Abstract Number: 577 • 2012 ACR/ARHP Annual Meeting
MRI of the Spine for Detection of Bone Spurs and Ankylosis in Patients with Ankylosing Spondylitis: Does MRI Offer Any Advantages Over Radiography?
Susanne Juhl Pedersen¹, Mikkel Østergaard², Robert GW Lambert³ and Walter P. Maksymowych⁴, ¹Dept. of Rheumatology, Copenhagen Center for Arthritis Research, Copenhagen, Denmark, ²Department of Rheumatology, Glostrup Hospital, Copenhagen, Denmark, ³Radiology, University of Alberta, Edmonton, AB, Canada, ⁴Department of Medicine, University of Alberta, Edmonton, AB, Canada
Background/Purpose: The current gold standard for detection of disease progression in ankylosing spondylitis (AS) is conventional radiography. The most reliable method mSASSS includes the anterior…
Abstract Number: 2470 • 2012 ACR/ARHP Annual Meeting
Does Structural Progression of Knee Osteoarthritis Measured with Magnetic Resonance Imaging or Radiography Predict Knee Replacement? – Data From the Osteoarthritis Initiative
Felix Eckstein¹, C. Kent Kwoh², Robert M. Boudreau³, Zhijie Wang⁴, Michael J. Hannon⁴, Wolfgang Wirth¹, Ali Guermazi⁵, Frank Roemer⁶, Michael C. Nevitt⁷, Markus R. John⁸, Leena Sharma⁹, Jeffrey W. Duryea¹⁰, David J. Hunter¹¹ and Osteoarthritis Initiative Investigators¹², ¹Anatomy & Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria, ²School of Medicine, Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, PA, ³Epidemiology, University of Pittsburgh, Pittsburgh, PA, ⁴Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁵Radiology, Boston University, Boston, MA, ⁶Klinikum Augsburg, Augsburg, Germany, ⁷Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, ⁸Novartis Pharma AG, Basel, Switzerland, ⁹Northwestern University, Chicago, IL, ¹⁰Dept of Radiology, Brigham & Women, Boston, MA, ¹¹Rheumatology, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia, ¹²San Francisco
Background/Purpose: Imaging biomarkers that predict relevant clinical endpoints, such as knee replacement (KR), are valuable tools for knee osteoarthritis prognosis. Currently, measurement of minimum radiographic…
Abstract Number: 1045 • 2012 ACR/ARHP Annual Meeting
Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Wrist in Rheumatoid Arthritis Patients Treated with Methotrexate, Intra-Articular Glucocorticoid and Adalimumab/Placebo
Mette Bjørndal Axelsen¹, Merete L. Hetland², Kim Hørslev-Petersen³, Kristian Stengaard-Pedersen⁴, Peter Junker⁵, Jan Pødenphant⁶, Jakob M. Møller⁷, Henning Bliddal⁸, Olga Kubassova⁹, Mikael Boesen¹⁰ and Mikkel Østergaard¹¹, ¹Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark, ²Copenhagen University Hospital Glostrup, Copenhagen, Denmark, ³Institute of Regional Health Services Research, University of Southern Denmark, Graasten, Denmark, ⁴Arhus University Hospital, Aarhus, Denmark, ⁵Odense University Hospital, Odense, Denmark, ⁶Copenhagen University at Gentofte, Hellerup, Denmark, ⁷Department of Radiology, Copenhagen University Hospital in Herlev, Copenhagen, Denmark, ⁸Department of Rheumatology, The Parker Institute, Copenhagen University Hospital at Frederiksberg, Copenhagen, Denmark, ⁹Image Analysis Ltd., Leeds, United Kingdom, ¹⁰The Parker Institute, Department of Rheumatology, Copenhagen University Hospital at Frederiksberg, Copenhagen, Denmark, ¹¹Dept of Rheumatology RM, Copenhagen University Hospital at Glostrup, Copenhagen, Denmark
Background/Purpose: To validate parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in an early rheumatoid arthritis (RA) clinical trial by comparison with clinical parameters of…

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