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Abstracts tagged "magnetic resonance imaging (MRI) and tofacitinib"

  • Abstract Number: 1181 • ACR/ARHP Annual Meeting 2014

    Effects of Tofacitinib on Bone Marrow Edema, Synovitis, and Erosive Damage in Methotrexate-Naïve Patients with Early Active Rheumatoid Arthritis (Duration ≤2 Years): Results of an Exploratory Phase 2 MRI Study

    Philip G. Conaghan1, M. Østergaard2, C. Wu3, D. van der Heijde4, F. Irazoque-Palazuelos5, P. Hrycaj6, Z. Xie7, R. Zhang7, B.T. Wyman7, J.D. Bradley7, K. Soma7 and B. Wilkinson7, 1Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United Kingdom, 2Copenhagen Center for Arthritis Research, Glostrup, Denmark, 3BioClinca Inc., Newark, CA, 4Leiden University Medical Center, Leiden, Netherlands, 5Servicio de Reumatología, Hospital Angeles Mocel, Mexico City, Mexico, 6Poznan University of Medical Sciences, Poznan, Poland, 7Pfizer Inc, Groton, CT

    Background/Purpose: Inflammation of the synovium and in particular the bone marrow, as assessed by magnetic resonance imaging (MRI), have been identified as prognostic indicators of…

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