Abstracts tagged "Magnetic resonance imaging (MRI)"

Abstract Number: 2614 • ACR Convergence 2025
Impact of Vagus Nerve-Mediated Neuroimmune Modulation on structural joint damage using Gd-MRI RAMRIS imaging in Biologic-Experienced Patients with Rheumatoid Arthritis
Charles Peterfy, MD, PhD¹, John Tesser², Yaakov Levine³, Melissa Evangelista⁴, Vibeke Strand⁵, Michael Weinblatt⁶ and David Chernoff⁷, ¹Spire Sciences, Inc., Boca Raton, FL, ²Arizona Arthritis & Rheumatology Associates, Phoenix, AZ, ³SetPoint Medical, Valencia, CA, ⁴SetPoint Medical Corporation, Valencia, CA, ⁵Stanford University School of Medicine, Palo Alto CA, Portola Valley, CA, ⁶Brigham and Women's Hospital/ Harvard Medical School, Waban, MA, ⁷SetPoint Medical, Sausalito, CA
Background/Purpose: Previously reported results from RESET-RA (ClinicalTrials.gov, NCT04539964) showed neuroimmune modulation via electrical stimulation of the left vagus nerve using an implantable device to treat…
Abstract Number: 1466 • ACR Convergence 2025
Impact of Bimekizumab on Spinal MRI Inflammation and Structural Lesions in Patients with Radiographic Axial Spondyloarthritis: 2-Year CANDEN Scoring Results from a Phase 3 Study and Its Open-Label Extension
Walter P. Maksymowych¹, Robert G. W. Lambert², Victoria Navarro-Compan³, Xenofon Baraliakos⁴, Jason Coarse⁵, Natasha de Peyrecave⁶ and Mikkel Ostergaard⁷, ¹Department of Medicine, University of Alberta, ⁵⁶⁸ Heritage Building, Edmonton, AB, Canada, ²University of Alberta, Department of Radiology & Diagnostic Imaging, Edmonton, AB, Canada, ³Department of Rheumatology, La Paz University Hospital, IdiPaz, Madrid, Spain, ⁴Rheumazentrum Ruhrgebiet Herne, Ruhr-University Bochum, Herne, Germany, ⁵UCB, Morrisville, NC, ⁶UCB, Brussels, Belgium, ⁷Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, and Copenhagen Center for Arthritis Research, Center for Rheumatology, Rigshospitalet, Glostrup, Denmark
Background/Purpose: Spinal inflammation and structural progression are key features of radiographic axial spondyloarthritis (r-axSpA).1 Canada-Denmark (CANDEN) scoring enables anatomical-based assessments of MRI inflammatory and structural…
Abstract Number: 0116 • ACR Convergence 2025
Cerebral small vessel disease in antiphospholipid syndrome: subtypes and total burden of cSVD on MRI
Chun Li¹, Jianping Guo², Yangyi Fan¹, Yu Kang¹ and Xiaodan Hu¹, ¹Peking University People's Hospital, Beijing, China (People's Republic), ²Peking University People's Hospital, Beijing, Beijing, China
Background/Purpose: Cerebrovascular diseases are common and severe neurological complications in antiphospholipid syndrome (APS). However, few studies focused on cerebral small vessel disease (cSVD) in APS.…
Abstract Number: 2541 • ACR Convergence 2025
Development of Severity Classification Criteria for Introduction of Infliximab for Chronic Pogressive Neuro-Behçet’s Disease
Shunsei Hirohata¹, Hirotoshi Kikuchi², Tetsuji Sawada³, Toshihiro Tono⁴, Mitsuhiro Takeno⁵ and Izumi Kawachi⁶, ¹Nobuhara Clinic, Tokyo, Japan, ²Teikyo University School of Medicine, ³-¹²-¹ ????????????¹³⁰⁸, Japan, ³Tokyo Medical University, Tokyo, Japan, ⁴Kitasato University School of Medicine, Kanagawa, Japan, ⁵Nippon Medical School Musashi Kosugi Hospital, Kawasaki, Japan, ⁶Niigata University Graduate School of Medicine and Dental Sciences and Niigata University Brain Institute, Niigata, Japan
Background/Purpose: Chronic progressive neuro-Behçet’s disease (CPNB) is characterized by progressive deterioration leading to disability and death. It has been appreciated that methotrexate (MTX) has beneficial…
Abstract Number: 1414 • ACR Convergence 2025
Multidimensional Assessment to Differentiate Early Psoriatic Arthritis from Cutaneous Psoriasis
Eugeniu Russu¹, Victor Cazac², Mircea Betiu³, Alesea Nistor³ and Liliana Groppa⁴, ¹"Nicolae Testemitanu" State Medical and Pharmaceutical University; ”Timofei Moșneaga” Republican Clinical Hospital, Chisinau, Moldova, ²Norwalk Hospital, Nuvance Health, Connecticut, ³State Medical and Pharmaceutical University ”Nicolae Testemițanu”, Chisinau, Chisinau, Moldova, ⁴State Medical and Pharmaceutical University ”Nicolae Testemițanu”, Chisinau, Moldova
Background/Purpose: Psoriatic arthritis (PsA) develops in ~20-30% of psoriasis patients. However, early PsA diagnosis is challenging due to heterogeneous, subtle symptoms and overlap with psoriasis…
Abstract Number: 2154 • ACR Convergence 2025
Whole-Body MRI Findings in a Cohort of Children with Chronic Nonbacterial Osteomyelitis
Mara Rodriguez¹, Maurice Davenport Munoz², Kiery Braithwaite³, Lori Ponder⁴, Kelly Rouster-Stevens⁵, Solveig Argeseanu Cunningham⁶ and Sampath Prahalad⁷, ¹Emory University School of Medicine / Children's Healthcare of Atlanta, Atlanta, GA, ²Emory University School of Medicine, Pediatrics, Atlanta, ³Children's Healthcare of Atlanta, Atlanta, GA, ⁴Emory University, Atlanta, GA, ⁵Emory University/Children's Healthcare of Atlanta, Peachtree Corners, GA, ⁶Emory Rollins School of Public Health Department of Global Health, Atlanta, GA, ⁷Emory + Children's Pediatric Institute, Atlanta, GA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is an autoinflammatory bone disorder characterized by multifocal, sterile bone inflammation in childhood. Whole-body magnetic resonance imaging (WB-MRI) allows for…
Abstract Number: 1239 • ACR Convergence 2025
JAK inhibition appears to alter clinical and neurobiological markers of nociplastic pain in rheumatoid arthritis: a 7T MRI Brain study
Kristian Stefanov¹, Andrew McGucken¹, Maxine Arnott¹, Tyrone Lau¹, Norah Aldehmi¹, Vinod Kumar², Neil McKay³, James Dale⁴, Lindsay Robertson⁵, James Brock¹, Flavia Sunzini⁶ and Neil Basu⁷, ¹University of Glasgow, Glasgow, United Kingdom, ²NHS Tayside, Dundee, United Kingdom, ³NHS Lothian, Edinburgh, United Kingdom, ⁴NHS Lanarkshire, Wishaw, United Kingdom, ⁵NHS Grampian, Aberdeen, United Kingdom, ⁶Glasgow University, Glasgow, United Kingdom, ⁷Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Pain remains a prevalent and highly impactful issue for people with rheumatoid arthritis (RA). Among modern day targeted therapies, the janus kinase (JAK) inhibitors…
Abstract Number: 2148 • ACR Convergence 2025
Initial MRI Findings as Predictors of Disease Phenotype in Juvenile Dermatomyositis: A Comparative Study of Myositis Specific Antibodies NXP2-Positive and Myositis Specific Antibody-Negative Patients in a Large Tertiary Hospital
Juan Torres Sanchez¹, Pritish Bawa², Andrea Ramirez¹, MaiLan Nguyen³, Amit Thakral⁴, Xiaofan Huang¹, J Herman Kan² and Marietta De Guzman¹, ¹Baylor College of Medicine, Houston, TX, ²Texas Childrens Hospital, Houston, TX, ³Baylor College of Medicine, Austin, TX, ⁴Texas Children’s Hospital, Houston, TX
Background/Purpose: Juvenile dermatomyositis (JDM) is the most common idiopathic inflammatory myopathy of childhood, characterized by proximal muscle weakness and distinctive cutaneous findings. Magnetic resonance imaging…
Abstract Number: 1205 • ACR Convergence 2025
Real-time MRI for assessment of swallowing impairment in inclusion body myositis and oculopharyngeal muscular dystrophy.
Rachel Zeng¹, Anke Rietveld², Omar Al-Bourini¹, Rosemarie HMJM Kroon², Arno Olthoff¹, Matthias Weidenmüller¹, Per-Ole Carstens¹, Isabel Kommerell¹, Saskia G Schütz¹, Corinne GC Horlings³, Johanna G Kalf³, Bert JM de Swart³, Baziel GM van Engelen², Tim Friede¹, Sabine Hofer¹, Jens Frahm⁴, Ali Seif Amir Hosseini¹, Jens Schmidt⁵ and Christiaan GJ Saris², ¹University Medical Center Göttingen, Göttingen, Germany, ²Radboudumc Research Institute for Medical Innovation, Nijmegen, Netherlands, ³Radboudumc Research Institute for Medical Innovation, Nijmegen, Germany, ⁴Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany, ⁵Immanuel University Hospital Rüdersdorf, Brandenburg Medical School, Rüdersdorf bei Berlin, Germany
Background/Purpose: Swallowing dysfunction -dysphagia- is a frequent and debilitating symptom in neuromuscular disorders, leading to malnutrition, cachexia, aspiration pneumonia and death. Identification of the underlying…
Abstract Number: 2128 • ACR Convergence 2025
Prevalence of Risks and Complications in a Longitudinal International Cohort of Children with Chronic Nonbacterial Osteomyelitis (CNO)
Jessica Kent¹, Eveline Wu², Melissa Oliver³, Sivia Lapidus⁴, Ummusen Akca⁵, Adriel Liau⁶, Pratyush Kore⁷, Ian Muse⁸, Ava Klein⁶, Emily Deng⁶, Iris Hamilton⁶, Haodong Chen⁷, Megan Nguyen⁷, Tianai Li⁹, Avril Wilson⁷, Jasmine Morden⁷, Shima Yasin¹⁰, Aleksander Lenert¹¹, Sara M. Stern¹², Antonella Insalaco¹³, Manuela Pardeo¹⁴, Gabriele Simonini¹⁵, Edoardo Marrani¹⁶, Xing Wang⁶, Bin Huang¹⁷, Leonard Kovallick¹⁸, Natalie Rosenwasser¹⁹, Erin Balay-Dustrude²⁰, Doaa Mosa²¹, Katerina Bouchalova²², Andrea Cabova²³, Jenna Thomason²⁰, Lori Tucker²⁴, Hermann Girschick²⁵, Ronald laxer²⁶, Marinka Twilt²⁷, Georgina Tiller²⁸, Jonathan Akikusa²⁹, Christian Hedrich³⁰, Karen Onel³¹, Fatma Dedeoglu³², Seza Özen³³, Polly Ferguson³⁴ and Yongdong (Dan) Zhao³⁵, ¹Medical College of Wisconsin, Wauwatosa, WI, ²UNC Chapel Hill, Chapel Hill, NC, ³Indiana University, Indianapolis, IN, ⁴Joseph M. Sanzari Children's Hospital, Center for Discovery and Innovation, Hackensack Meridian School of Medicine, Montclair, NJ, ⁵Hacettepe University, Ankara, Turkey, ⁶Seattle Children's Hospital, Seattle, ⁷Seattle Children’s Research Institute, Seattle, ⁸University of Washington, Department of Pediatrics, Seattle Children's Hospital, Seattle, ⁹Seattle Children's Research institute, Seattle, ¹⁰Univeristy of Iowa, Iowa City, ¹¹University of Iowa, Iowa City, IA, ¹²University of Utah, Salt Lake City, UT, ¹³IRCCS Ospedale Pediatrico Bambino Gesu', Rome, Italy, ¹⁴IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy, ¹⁵Rheumatology Unit, ERN-ReCONNET center, Meyer Children's Hospital IRCCS, Firenze, Firenze, Italy, ¹⁶University of Florence, Firenze, Italy, ¹⁷Cincinnati Children's Hospital, Cinciannati, OH, ¹⁸The University of North Carolina at Chapel Hil, Chapel Hill, ¹⁹Seattle Children's Hospital, seattle, WA, ²⁰University of Washington, Seattle, WA, ²¹Mansoura University Hospitals, Mansoura City, Egypt, ²²Palacký University Olomouc, Olomouc, Czech Republic, ²³Faculty of Medicine and Dentistry Palacky University Olomouc, Olomouc, Czech Republic, ²⁴BC Children's Hospital, Vancouver, BC, Canada, ²⁵Vivantes Clinic Friedrichshain, Wuerzburg, Germany, ²⁶The Hospital for Sick Children, Toronto, ON, Canada, ²⁷Alberta Children's Hospital, Alberta, Canada, ²⁸Royal Children’s Hospital, Melborne, Australia, ²⁹The Royal Children's Hospital, Parkville, Victoria, Australia, ³⁰University of Liverpool, Liverpool, United Kingdom, ³¹HSS, New York, NY, ³²Boston Children's Hospital, Boston, MA, ³³Hacettepe University Medical Faculty, Ankara, Turkey, ³⁴University of Iowa Carver College of Medicine, Iowa City, IA, ³⁵Seattle Children’s Research Institute, Redmond, WA
Background/Purpose: Chronic nonbacterial osteomyelitis (CNO) is associated with various comorbidities and long-term complications. The CHronic nonbacterial Osteomyelitis International Registry (CHOIR) is a multi-national database that…
Abstract Number: 0716 • ACR Convergence 2025
Utility of Follow-Up Cardiac Magnetic Resonance Imaging In Patients With Eosinophilic Granulomatosis With Polyangiitis
Chelsea Cheng¹, Justine Lafleur-Careau², Navneet Kang¹, Medha Soowamber³ and Christian Pagnoux³, ¹Mount Sinai Hospital, Toronto, Canada, ²Mount Sinai Hospital, Saint-Augustin-de-Desmaures, Canada, ³Mount Sinai Hospital, Toronto, ON, Canada
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare multisystem disorder characterized by asthma, rhinitis, peripheral blood eosinophilia, and necrotizing vasculitis of small vessels. Cardiac…
Abstract Number: 2091 • ACR Convergence 2025
Multiplanar MRI Quantification of Effusion-Synovitis: Reliability and Potential Investigative Utility for Inflammation-Mediated Knee Conditions
Greg Gilles¹, Dagoberto Robles², Luke Grawer³, Nathaniel H. Christiansen⁴, Karim Jayyusi³, Ali Shaikh³, Rongrong Tang⁵, Mihra S. Taljanovic³, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ²University of Arizona, Tucson, AZ, ³University of Arizona, Tucson, ⁴University of Arizona, Stockton, NJ, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Effusion-synovitis (ES) is often seen in knee osteoarthritis (KOA), and MRI-detected ES may serve as a potential imaging biomarker of disease activity, progression, and…
Abstract Number: 0681 • ACR Convergence 2025
Evaluation of Serial Cardiovascular Magnetic Resonance Monitoring and Immunosuppressive Therapy in Predicting Long-Term Outcomes in Systemic Sclerosis
Aïcha Kante¹, Sandra Mghaieth², bertrand Dunogue³, Alice berezne³, Cloé Comarmond¹, Marie-Pierre Revel², Guillaume Chassagnon², Luc Mouthon³ and Benjamin Chaigne³, ¹Department of Internal Medicine, Lariboisière University Hospital, Université Paris Cité, Assistance Publique Hôpitaux de Paris, INSERM U⁹⁴², Paris, France, ²Radiology Department, Cochin University Hospital, Université Paris Cité, AP-HP, Paris, France, ³Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Cochin University Hospital, Université Paris Cité, AP-HP, Paris, France
Background/Purpose: Systemic sclerosis (SSc) is a connective tissue disease that can manifest as widespread skin and visceral fibrosis, potentially affecting major organs including the heart.…
Abstract Number: 2085 • ACR Convergence 2025
Estimating the Association between Effusion-synovitis and Knee Pain in a Subset of Participants with Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative (OAI)
Dagoberto Robles¹, Greg Gilles², Nathaniel H. Christiansen³, Luke Grawer⁴, Karim Jayyusi⁴, Ali Shaikh⁴, Rongrong Tang⁵, Mihra S. Taljanovic⁴, Jeffrey Duryea⁶, Edward J. Bedrick⁵ and C. Kent Kwoh⁷, ¹University of Arizona, Tucson, AZ, ²University of Arizona Arthritis Center, The University of Arizona College of Medicine, Tucson, AZ, ³University of Arizona, Stockton, NJ, ⁴University of Arizona, Tucson, ⁵The University of Arizona Arthritis Center, University of Arizona, Tucson, ⁶Brigham and Women’s Hospital, Boston, MA, ⁷The University of Arizona Arthritis Center, University of Arizona, Tucson, AZ
Background/Purpose: Even though knee pain is ubiquitous in knee osteoarthritis (KOA) patients, currently there are limited treatment options which are only minimally or moderately efficacious…
Abstract Number: 0852 • ACR Convergence 2025
LEVI-04 Significantly Reduces Bone Marrow Lesions and Symptoms in Knee Osteoarthritis: Results from a Phase II RCT
Simon Westbrook¹, Ali Guermazi² and Philip Conaghan³, ¹Levicept Ltd, Sandwich, United Kingdom, ²Boston University, West Roxbury, MA, ³University of Leeds, Leeds, United Kingdom
Background/Purpose: Bone marrow lesions (BMLs), detectable on MRI as areas of ill-defined high signal intensity on fluid-sensitive sequences, are a common feature of osteoarthritis (OA),…

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