macrophages and systemic sclerosis Archives

Abstract Number: 1013 • ACR/ARHP Annual Meeting 2018
Circulating Hybrid M1/M2 Monocytes/Macrophages in Systemic Sclerosis Patients with Lung Involvement
Maurizio Cutolo¹, Amelia Chiara Trombetta², Veronica Tomatis³, Sabrina Paolino⁴, Carmen Pizzorni¹, Vanessa Smith⁵, Paola Contini⁶, Paola Montagna³, Renata Brizzolara² and Stefano Soldano³, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁶Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by immune system alterations, vasculopathy and fibrosis [1]. SSc-related interstitial lung disease (ILD) represents a common…
Abstract Number: 1730 • ACR/ARHP Annual Meeting 2017
IL-6 Mediates Activation of Macrophages in Patients with Systemic Sclerosis
Rajan Bhandari¹, Michael Ball², Viktor Martyanov³, Dillon Popovich⁴, Mary A. Carns⁵, Kathleen Aren⁵, Monique Hinchcliff⁶, Michael L. Whitfield⁷ and Patricia A. Pioli⁸, ¹Geisel School of Medicine at Dartmouth, lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Geisel School of Medicine at Dartmouth, hanover, NH, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁶Rheumatology, Northwestern Medicine, Chicago, IL, ⁷Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁸Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Activated macrophages (MØs) have been implicated as regulators of fibrosis in patients with systemic sclerosis (SSc), and we have shown that MØs from SSc…
Abstract Number: 1713 • ACR/ARHP Annual Meeting 2014
Increased Number of CD206⁺cells in Peripheral Blood and Skin of Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Renata Brizzolara¹, Paola Montagna¹, Barbara Villaggio³, Alberto Sulli⁴, Carmen Pizzorni⁴, Sabrina Paolino¹, Bruno Seriolo⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
Background/Purpose Systemic sclerosis (SSc) is characterised by microvascular damage, immune cell activation and fibrosis of the skin and internal organs. In SSc, the immune-inflammatory infiltrate…
Abstract Number: 1516 • ACR/ARHP Annual Meeting 2012
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
Romy Christmann¹, Allison Mathes², Giuseppina Stifano², Alsya J. Affandi³, Andreea Bujor³, Cristina Padilla³ and Robert Lafyatis³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA
Background/Purpose: to investigate the expression of Thymic Stromal Lymphopoietin (TSLP) in diffuse cutaneous systemic sclerosis (dcSSc) patients and explore its effects in vivo and in vitro…

Abstracts tagged "macrophages and systemic sclerosis"

Circulating Hybrid M1/M2 Monocytes/Macrophages in Systemic Sclerosis Patients with Lung Involvement

IL-6 Mediates Activation of Macrophages in Patients with Systemic Sclerosis

Increased Number of CD206+cells in Peripheral Blood and Skin of Systemic Sclerosis Patients

TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb

Increased Number of CD206⁺cells in Peripheral Blood and Skin of Systemic Sclerosis Patients