Abstracts tagged "macrophages and systemic sclerosis"

Abstract Number: 1013 • 2018 ACR/ARHP Annual Meeting
Circulating Hybrid M1/M2 Monocytes/Macrophages in Systemic Sclerosis Patients with Lung Involvement
Maurizio Cutolo¹, Amelia Chiara Trombetta², Veronica Tomatis³, Sabrina Paolino⁴, Carmen Pizzorni¹, Vanessa Smith⁵, Paola Contini⁶, Paola Montagna³, Renata Brizzolara² and Stefano Soldano³, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genoa, Italy, ³Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic San Martino, University of Genoa, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, San Martino Polyclinic Hospital, Genoa, Italy, Genova, Italy, ⁵Department of Rheumatology, Ghent University Hospital, Ghent, Belgium, ⁶Division of Clinical Immunology, Department of Internal Medicine, University of Genova, IRCCS Polyclinic San Martino, Genova, Italy, Genova, Italy
Background/Purpose: Systemic sclerosis (SSc) is an autoimmune disease characterized by immune system alterations, vasculopathy and fibrosis [1]. SSc-related interstitial lung disease (ILD) represents a common…
Abstract Number: 1730 • 2017 ACR/ARHP Annual Meeting
IL-6 Mediates Activation of Macrophages in Patients with Systemic Sclerosis
Rajan Bhandari¹, Michael Ball², Viktor Martyanov³, Dillon Popovich⁴, Mary A. Carns⁵, Kathleen Aren⁵, Monique Hinchcliff⁶, Michael L. Whitfield⁷ and Patricia A. Pioli⁸, ¹Geisel School of Medicine at Dartmouth, lebanon, NH, ²Geisel School of Medicine at Dartmouth, Lebanon, NH, ³Department of Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁴Geisel School of Medicine at Dartmouth, hanover, NH, ⁵Northwestern University, Feinberg School of Medicine Scleroderma Program, Chicago, IL, ⁶Rheumatology, Northwestern Medicine, Chicago, IL, ⁷Molecular and Systems Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, ⁸Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH
Background/Purpose: Activated macrophages (MØs) have been implicated as regulators of fibrosis in patients with systemic sclerosis (SSc), and we have shown that MØs from SSc…
Abstract Number: 1713 • 2014 ACR/ARHP Annual Meeting
Increased Number of CD206⁺cells in Peripheral Blood and Skin of Systemic Sclerosis Patients
Stefano Soldano¹, Paola Contini², Renata Brizzolara¹, Paola Montagna¹, Barbara Villaggio³, Alberto Sulli⁴, Carmen Pizzorni⁴, Sabrina Paolino¹, Bruno Seriolo⁴ and Maurizio Cutolo⁴, ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ²Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy
Background/Purpose Systemic sclerosis (SSc) is characterised by microvascular damage, immune cell activation and fibrosis of the skin and internal organs. In SSc, the immune-inflammatory infiltrate…
Abstract Number: 1516 • 2012 ACR/ARHP Annual Meeting
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
Romy Christmann¹, Allison Mathes², Giuseppina Stifano², Alsya J. Affandi³, Andreea Bujor³, Cristina Padilla³ and Robert Lafyatis³, ¹Rheumatology, Boston University School of Medicine, Boston, MA, ²Rheumatology, Boston University Medical Center, Boston, MA, ³Rheumatology, Boston University, Boston, MA
Background/Purpose: to investigate the expression of Thymic Stromal Lymphopoietin (TSLP) in diffuse cutaneous systemic sclerosis (dcSSc) patients and explore its effects in vivo and in vitro…

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