Abstracts tagged "macrophages and rheumatoid arthritis (RA)"

Abstract Number: 2211 • 2018 ACR/ARHP Annual Meeting
Technetium Tc 99m Tilmanocept: A Targeted Immunodiagnostic Radiopharmaceutical for the Assessment of Synovial Macrophage Activity in Rheumatoid Arthritis
Arash Kardan¹, Allison Kissling², Bonnie Abbruzzese², Ahmad Ismail², Rachael Hershey², Carley Hartings², David Ralph², Izabela Gierach², Michael Blue², Hannah Bailey², Christopher Gablemann², Katherine Repp² and Frederick Cope², ¹Charles F. Kettering Memorial Hospital and Wright State University Boonshoft School of Medicine, Dayton, OH, ²Navidea Biopharmaceuticals, Inc., Dublin, OH
Background/Purpose: Activated macrophages are a critical component of the inflammatory etiology of RA. It is well established that these macrophages perpetuate joint inflammation and destruction…
Abstract Number: 403 • 2017 ACR/ARHP Annual Meeting
Cardiac Immune Cells in SKG Mice with Inflammatory Arthritis before and after Myocardial Infarction
Christine Hsieh¹, Isabella Imhof², Luyi Li³, Erene Niemi¹, Matthew Bell¹, Joel Karliner⁴ and Mary Nakamura⁵, ¹Medicine, SFVA/UCSF, San Francisco, CA, ²Medicine, SFVA/NCIRE, San Francisco, CA, ³SFVA/UCSF, San Francisco, CA, ⁴Medicine, SFVA/UCSF, San, CA, ⁵Department of Medicine, Division of Rheumatology, UCSF/SFVA, San Francisco, CA
Background/Purpose: Cardiovascular disease is a major cause of morbidity and mortality in patients with rheumatoid arthritis (RA). RA patients have an increased incidence of both…
Abstract Number: 521 • 2016 ACR/ARHP Annual Meeting
Subcutaneous Adipose Tissue from Rheumatoid Arthritis Patients Is Characterized By an Abundance of Macrophages That Are Associated with Autoantibodies, Systemic Inflammation, and Immunomodulation
Jon T. Giles¹, Anthony W Ferrante², Rachel Broderick³, Afshin Zartoshti⁴, Janine Rose³, Hui-Zhu Zhang³ and Robert Winchester³, ¹Division of Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ²Endocrinology, Nutrition, and Preventive Medicine, Columbia University, College of Physicians & Surgeons, New York, NY, ³Rheumatology, Columbia University, College of Physicians & Surgeons, New York, NY, ⁴Rheumatology, Columbia University, College of Physicians & Surgeons, New York city, NY
Background/Purpose: Adipose tissue macrophages (ATMs) are a potent source of inflammatory cytokines with profound effects on adipose tissue function and systemic inflammation, yet their potential…
Abstract Number: 1033 • 2016 ACR/ARHP Annual Meeting
Targeting Notch-Activated M1 Macrophages Attenuates Joint Tissue Damage in a Mouse Model of Inflammatory Arthritis
Wen Sun^1,2, Hengwei Zhang³, Hua Wang^1,2, Yahui Grace Chiu⁴, Christopher T. Ritchlin⁵, Amy Kiernan¹, Brendan Boyce¹ and Lianping Xing¹, ¹University of Rochester Medical Center, Rochester, NY, ²Nanjing Medical University, Nanjing, China, ³Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, ⁴Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, ⁵Allergy Immunology & Rheumatology, University of Rochester Medical Center, Rochester, NY
Background/Purpose: Increased expression of Notch signaling molecules has been reported in synovial samples of patients with rheumatoid arthritis (RA). However, the identity of the cell…
Abstract Number: 1605 • 2015 ACR/ARHP Annual Meeting
Enhanced Oxidant Signaling in Inflammatory Macrophages in Rheumatoid Arthritis (RA) and in Coronary Artery Disease (CAD)
Tsuyoshi Shirai¹, Benedikt Schaefgen¹, Barbara Wallis¹, Eric L. Matteson², Themistocles L. Assimes³, David G. Harrison⁴, Jorg Goronzy⁵ and Cornelia M. Weyand⁶, ¹Medicine: Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ²Rheumatology, Mayo Clinic, Rochester, MN, ³Stanford University School of Medicine, Stanford, CA, ⁴Clinical Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, ⁵Medicine/Division of Immunology & Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁶Medicine, Stanford University School of Medicine, Stanford, CA
Background/Purpose: RA patients have a 2-fold increased risk of developing coronary artery disease (CAD) regardless of traditional risk factors. Atherosclerosis, the underlying process in CAD,…
Abstract Number: 1473 • 2014 ACR/ARHP Annual Meeting
Manocept-Cy3 Localizes CD206 + Macrophages in Synovial Tissue and Fluid from Rheumatoid Arthritis Patients Differentially Compared to Controls
Nicholas A. Young¹, Larry Schlesinger², Thomas J. Rosol³, Fred Cope⁴ and Wael N. Jarjour⁵, ¹Immunology and Rheumatology, The Ohio State University Wexner Medical Center, Columbus, OH, ²Center for Microbial Interface Biology, Department of Microbial Infection and Immunity, The Ohio State University College of Medicine, Columbus, OH, ³The Ohio State University College of Veterinary Medicine, Columbus, OH, ⁴Navidea Biopharmaceuticals, Dublin, OH, ⁵Dept of Rheumatology/Medicine, The Ohio State University Wexner Medical Center, Columbus, OH
Background/Purpose: Early identification of rheumatoid arthritis (RA) would allow aggressive treatment with disease modifying rheumatic drugs and provide a system to monitor patient responses. Therefore,…
Abstract Number: 1132 • 2014 ACR/ARHP Annual Meeting
A Novel Epigenetic Mark, Histone H1 Fucosylation, Orchestrates Macrophage Differentiation and Plasticity By Remodeling the Enhancer Landscape in Rheumatoid Arthritis
Jun Li¹, Keith Giles², Parastoo Azadi³, Mayumi Ishihara³, PingAr Yang¹, Qi Wu¹, Bao Luo¹, David M. Spalding⁴, James A Mobley⁵, S. Louis Bridges Jr.^6,7, Hui-Chen Hsu¹ and John D. Mountz^1,8, ¹Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, ²University of Alabama at Birmingham, Stem cell Institute, Birmingham, AL, ³University of Georgia, Complex Carbohydrate Research Center, Athens, GA, ⁴University of Alabama at Birmingham, Division of Clinical Immunology & Rheumatology, Birmingham, AL, ⁵University of Alabama at Birmingham, Comprehensive Cancer Center Mass Spectrometry/Proteomics Facility, Birmingham, AL, ⁶University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Clinical Immunology & Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁸Birmingham VA Medical Center, Birmingham, AL
Background/Purpose There is an imbalance of inflammatory M1 vs. anti-inflammatory M2 macrophages (MΦs) in rheumatoid arthritis (RA). The epigenetic codes underlying this M1 dominating pathogenesis…
Abstract Number: 344 • 2014 ACR/ARHP Annual Meeting
Reduced Macrophages in the Synovium Contribute to the Effective Treatment of Spontanneous Arthritis Observeded in Human TNF-Transgenic Mice
Robert Birkett¹, Qi Quan Huang¹, Bo Shi² and Richard Pope³, ¹Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ³Medicine/Rheumatology Div, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose Macrophages in rheumatoid arthritis (RA) synovial tissue (ST) produce high levels of inflammatory cytokines/chemokines and exhibit enhanced differentiation into osteoclasts in the pannus, playing…
Abstract Number: 2167 • 2014 ACR/ARHP Annual Meeting
Snapin Is Critical for Cathepsin D Activation and the Normal Lysosomal Function
Bo Shi¹, Qi Quan Huang², Robert Birkett², Renee E. Koessler¹, Andrea Dorfleutner¹, Christian Stehlik¹ and Richard M. Pope¹, ¹Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL, ²Medicine/Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: Our recent data indicates that Snapin, a SNAP associated protein, is critical for maintaining healthy autophagy and monocytes to macrophage (MFs) differentiation which requires…
Abstract Number: 1635 • 2012 ACR/ARHP Annual Meeting
Polyarthritis Caused by TIARP (TNFAIP9) Deficiency Critically Dependent On Dysregulated STAT3, NF-κB Signaling and Cell Death in Macrophage
Asuka Inoue¹, Isao Matsumoto¹, Naoto Umeda¹, Yuki Tanaka¹, Satoru Takahashi² and Takayuki Sumida¹, ¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan, ²Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Tsukuba city, Ibaraki, Japan
Background/Purpose: TNFα-induced adipose-related protein (TIARP) is a six-transmembrane protein induced by TNFα and IL-6 in adipose tissue. Recently, we found that TIARP is dominantly expressed…
Abstract Number: 1602 • 2012 ACR/ARHP Annual Meeting
Tie2 Signalling Induces a Pro-Inflammatory and Pro-Angiogenic Phenotype in Differentiated Macrophages, Independently of Macrophage Polarization Conditions, and Contributes to Production of Cytokines Elevated in Early Rheumatoid Arthritis
Samuel Garcia¹, Sarah Krausz², Carmen A. Ambarus³, Bea Malvar Fernandez², Dominique L. Baeten⁴, Paul P. Tak⁵ and Kris A. Reedquist², ¹Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ²Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, ³Department Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁴Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Amsterdam, Netherlands, ⁵Department of Experimental Immunology, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam and GlaxoSmithKline, Amsterdam, Netherlands
Background/Purpose: Angiopoietin (Ang) -1 and -2 signalling to the Tie2 tyrosine kinase receptor has an essential role in blood vessel remodeling and angiogenesis. Ang-1, Ang-2…
Abstract Number: 1206 • 2012 ACR/ARHP Annual Meeting
Gp96 Exacerbate the Inflammation of Rheumatoid Arthritis
Qi Quan Huang¹, Robert Birkett², J.-P. Jin³ and Richard M. Pope⁴, ¹Medicine/Rheumatology, Northwestern University, Chicago, IL, ²Division of Rheumatology, Department od Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, ³Physiology, Wayne State University, Detroit, MI, ⁴Rheumatology, Northwestern University Feinberg school of Medicine, Chicago, IL
Background/Purpose: The mechanisms that contribute to the persistent activation of macrophages in rheumatoid arthritis (RA) are incompletely understood. Toll-like receptors (TLRs) have been implicated in…

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