Abstracts tagged "macrophages and nephrogenic fibrosing dermopathy"

Abstract Number: 2904 • 2013 ACR/ARHP Annual Meeting
Gadolinium-Based Compounds Induce NLRP3-Dependent IL-1β Production and Peritoneal Inflammation
Jonathan Kay^1,2, Lukas Bossaller³, Christian Schmidt-Lauber^1,4, Hani H. Abujudeh⁵, Gregory Vladimer³, Eicke Latz^3,6, Katherine A. Fitzgerald³, Ann Marshak-Rothstein¹ and Ellen M. Gravallese^1,7, ¹Department of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, ²UMass Memorial Medical Center and University of Massachusetts Medical School, Worcester, MA, ³Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, ⁴Institute of Experimental Musculoskeletal Medicine (IEMM), University Hospital Münster, Münster, Germany, ⁵Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, ⁶Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany, ⁷Department of Medicine, Division of Rheumatology, UMass Memorial Medical Center, Worcester, MA
Background/Purpose: Nephrogenic systemic fibrosis (NSF) is a progressive iatrogenic fibrosing disorder that develops in patients with chronic kidney disease following administration of gadolinium (Gd)-based contrast…
Abstract Number: 1496 • 2012 ACR/ARHP Annual Meeting
Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts
Peter J. Wermuth¹, Francesco Del Galdo², Sankar Addya³, Paolo Fortina³ and Sergio A. Jimenez¹, ¹Jefferson Institute of Molecular Medicine, Division of Connective Tissue Diseases and Scleroderma Center,Thomas Jefferson University, Philadelphia, PA, ²Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, ³Department of Cancer Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA
Background/Purpose: Metallothioneins bind heavy metals with high affinity and can serve as storage proteins for labile Zn2+ which in turn can regulate immune system activity…

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