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Abstracts tagged "Lysosomal acidification and Immune complex accumulation"

  • Abstract Number: 1024 • 2019 ACR/ARP Annual Meeting

    Lysosome Defects in SLE Promote the Accumulation of Nuclear Antigens on the Surface of Hematopoietic Cells

    Sun Ah Kang1, Jennifer Rogers 2, Saira Sheikh 3, Megan Clowse 2, Lisa Criscione-Schreiber 2 and Barb Vilen 4, 1University of NOrth Carolina at Chapel Hlil, Chapel Hill, NC, 2Duke University, Durham, 3University of North Carolina, Chapel Hill, NC, 4University of North Carolina CHapel Hill, Chapel Hill, NC

    Background/Purpose:   Impaired clearance of cell debris allows nuclear self-antigens such as DNA to accumulate, bind autoreactive IgG and form immune complexes (IgG-ICs) in SLE.  We…
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ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

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