Abstracts tagged "Lysosomal acidification and Immune complex accumulation"

Abstract Number: 1024 • 2019 ACR/ARP Annual Meeting
Lysosome Defects in SLE Promote the Accumulation of Nuclear Antigens on the Surface of Hematopoietic Cells
Sun Ah Kang¹, Jennifer Rogers ², Saira Sheikh ³, Megan Clowse ², Lisa Criscione-Schreiber ² and Barb Vilen ⁴, ¹University of NOrth Carolina at Chapel Hlil, Chapel Hill, NC, ²Duke University, Durham, ³University of North Carolina, Chapel Hill, NC, ⁴University of North Carolina CHapel Hill, Chapel Hill, NC
Background/Purpose: Impaired clearance of cell debris allows nuclear self-antigens such as DNA to accumulate, bind autoreactive IgG and form immune complexes (IgG-ICs) in SLE. We…