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Abstracts tagged "lymphopenia"

  • Abstract Number: 2875 • ACR/ARP Annual Meeting 2019

    Effects of Filgotinib on Anemia, Thrombocytopenia and Leukopenia: Results from a Phase 3 Study in Patients with Active Rheumatoid Arthritis and Prior Inadequate Response or Intolerance to Biological DMARDs

    Mark Genovese1, Kenneth Kalunian 2, Jacques-Eric Gottenberg 3, Beatrix Bartok 4, YingMeei Tan 4, Ying Guo 4, Chantal Tasset 5, John Sundy 4, Kurt de Vlam 6, David Walker 7 and Tsutomu Takeuchi 8, 1Stanford University, Stanford, CA, 2Division of Rheumatology, Allergy, and Immunology, University of California San Diego, La Jolla, CA, 3Department of Rheumatology, Strasbourg University Hospital, Strasbourg, France, 4Gilead Sciences, Inc., Foster City, CA, 5Galapagos NV, Mechelen, Belgium, 6Department of Rheumatology, Universitair Ziekenhuis Leuven, Leuven, Belgium, 7Northumbria Healthcare, Northumbria, United Kingdom, 8Keio University School of Medicine, Tokyo, Japan

    Background/Purpose: Anemia, thrombocytopenia and leukopenia in RA patients treated with non-Janus Kinase 1 (JAK1) selective inhibitors may be due to inhibition of hematopoietic growth factors…
  • Abstract Number: 1822 • ACR/ARHP Annual Meeting 2016

    CD4+ T Cell Lymphopenia Is Associated with Deficient Ubiquitination of the Cell Cycle Inhibibitor p27kip1 By the E3 Ligase Casitas B-Lineage Lymphoma-b in Patients with Systemic Lupus Erythematosus

    Diana Gómez-Martín, Jorge Romo-Tena, Javier Merayo-Chalico and Jorge Alcocer-Varela, Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Lymphopenia has been associated with the development of autoimmune diseases. Particularly, in patients with Systemic Lupus Erythematosus (SLE) is a common clinical feature. However,…
  • Abstract Number: 1762 • ACR/ARHP Annual Meeting 2015

    Reciprocal Roles of Intestinal Microbiota in the Pathogenesis of Organ-Specific Autoimmune Diseases in a Lymphopenia-Induced Autoimmunity Mouse Model

    Toshiki Eri1, Kimito Kawahata2, Ei Bannai1, Takeyuki Kanzaki3, Lisa Akahira1, Kazuya Michishita1 and Kazuhiko Yamamoto1, 1Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, 3Internal Medicine, Yamanashi Prefectural Central Hospital, Yamanashi, Japan

    Background/Purpose: Past studies reported lymphopenia mouse transfer model which transfer CD4+CD25- cells from wild-type BALB/c mouse into athymic nude BALB/c mice produce lupus-like systemic autoantibodies…
  • Abstract Number: 2990 • ACR/ARHP Annual Meeting 2014

    Risk Factors for Posterior Reversible Encephalopathy Syndrome in Systemic Lupus Erythematosus Patients: A Single Center Study

    Javier Merayo-Chalico1, Elia Apodaca2, Ana Barrera-Vargas3, Jorge Alcocer-Varela3 and Diana Gómez-Martín3, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Internal Medicine, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose:  Posterior reversible encephalopathy syndrome (PRES) is a well-known but rare complication in systemic lupus erythematosus (SLE) patients (
  • Abstract Number: 1658 • ACR/ARHP Annual Meeting 2014

    Renal Thrombotic Microangiopathy in Systemic Lupus Erythematosus: Novel Risk Factors and Clinical Outcomes

    Ana Barrera-Vargas1, Rodrigo Rosado-Canto2, Javier Merayo-Chalico3, Jorge Alcocer-Varela1 and Diana Gómez-Martín1, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico, 3Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

    Background/Purpose: Thrombotic microangiopathy (TMA) is characterized by microvascular occlusion, systemic or intrarenal platelet aggregation and mechanical injury to erythrocytes.  It is a pathological endpoint that…
  • Abstract Number: 1579 • ACR/ARHP Annual Meeting 2013

    Novel Risk Factors For Thrombotic Thrombocytopenic Purpura In Systemic Lupus Erythematosus  patients

    Javier Merayo-Chalico1, Diana Gómez-Martín2, Roberta Demichelis-Gómez3, Sandra Rajme-Lopez2, Luis Aparicio-Vera2 and Jorge Alcocer-Varela2, 1Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico, 3Haematology, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico

    Background/Purpose: Thrombotic thrombocytopenic purpura (TTP) is an uncommon disease characterized by thrombocytopenia and microangiopathic hemolytic anemia and, in some cases, fever, neurologic and/or renal abnormalities.…

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