Abstracts tagged "lymphocytes and systemic lupus erythematosus (SLE)"

Abstract Number: 686 • 2017 ACR/ARHP Annual Meeting
Endothelial Dysfunction in Systemic Lupus Erythematosus Patients without Cardiovascular events and Risk Factors: Correlation with Microvascular Alterations and angiogenic t Cells
Ilaria Cavazzana¹, Mara Taraborelli², Silvia Piantoni³, Ivano Bonadei⁴, Edoardo Sciatti⁵, Micaela Fredi⁶, Marco Metra⁴, Angela Tincani⁷, Franco Franceschini¹ and Enrico Vizzardi⁴, ¹Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ²Internal Medicine; Ospedale Mellini, Chiari (Brescia), Italy, ³Rheumatology and Clinical Immunology Unit, Spedali Civili, University of Brescia, Brescia, Italy, ⁴Cardiology Unit, Spedali Civili, University of Brescia, Brescia, Italy, ⁵Cardiology Unit, Spedali Civili, University of Brescia, Brsecia, Italy, ⁶Department of Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Rheumatology and Clinical Immunology, Spedali Civili of Brescia, Brescia, Italy, ⁷Rheumatology and Clinical Immunology, Spedali Civili and University of Brescia, Brescia, Italy
Background/Purpose: early identification of subclinical cardiovascular disease (CVD) in systemic lupus erythematosus (SLE) patients is mandatory to reduce morbidity and mortality. Endothelial dysfunction (ED) is…
Abstract Number: 645 • 2013 ACR/ARHP Annual Meeting
Transcript Profiling Of Blood and Kidney Biopsies From Chinese Patients With Lupus Nephritis Reveals Concordant Activation Of Type I IFN Signaling In The Blood and Kidney, Reduced B Cell Presence In The Blood, and Increased Macrophages In The Kidney
Zheng Liu¹, Chris, A. Morehouse¹, Xinfang Huang², Philip Brohawn¹, Nan Shen², Yihong Yao¹ and Brandon W. Higgs¹, ¹Translational Sciences, MedImmune, LLC, Gaithersburg, MD, ²Dept of Rheumatology, Shanghai Ren Ji Hospital, Shanghai, China
Background/Purpose: Up-regulated expression of type I interferon-regulated genes has consistently been observed within the peripheral blood in a large proportion of patients with active systemic…
Abstract Number: 555 • 2013 ACR/ARHP Annual Meeting
Therapeutic Inhibition Of Anti-Apoptotic BCL-2 Family Proteins In a Murine Model Of Lupus Nephritis
Li Chun Wang¹, Stuart Perper², Danise Perron³, Edit Tarcsa⁴, Philip Bardwell³, Neelufar Mozaffarian⁵, Andrew Souers⁵, Steven Elmore⁶, Tariq Ghayur⁷ and Lisa Olson³, ¹Immunology, AbbVie Inc, AbbVie Bioresearch Center, Worcester, MA, ²Pharmacology, AbbVie Bioresearch Center, Inc, Worcester, MA, ³Immunology, AbbVie Bioresearch Center, Inc, Worcester, MA, ⁴Immunology, AbbVie Bioresearch Center, Worcester, MA, ⁵AbbVie, North Chicago, IL, ⁶AbbVie Inc, North Chicago, IL, ⁷AbbVie Bioresearch Center, Inc, Worcester, MA
Background/Purpose: Apoptosis is both a conserved and highly regulated process that is essential for normal development and tissue homeostasis. This process, also known as programmed…

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