Abstracts tagged "Lyme disease"

Abstract Number: 984 • 2014 ACR/ARHP Annual Meeting
Apolipoprotein B Is a Target of T and B Cell Responses in a Subgroup of Patients with Lyme Disease
Jameson T. Crowley¹, Elise E. Drouin², Qi Wang³, Gail McHugh⁴, Catherine E. Costello³ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁴Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Boston, MA, ⁵Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Borrelia burgdorferi-induced autoimmunity in affected joints has been hypothesized to be a contributing factor to antibiotic-refractory Lyme arthritis (ARLA). Our prior study, which combined…
Abstract Number: 983 • 2014 ACR/ARHP Annual Meeting
Identification of Annexin A2 As an Autoantigen in Rheumatoid Arthritis and in Lyme Arthritis
Annalisa Pianta¹, Elise E. Drouin², Sheila Arvikar³, Catherine E. Costello⁴ and Allen C. Steere⁵, ¹Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ²Medicine, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, ³Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Boston, MA, ⁴Center for Biomedical Mass Spectrometry, Boston University School of Medicine, Boston, MA, ⁵Medicine, Center for Immunolgy and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Background/Purpose Disease-associated HLA-DR molecules are the greatest genetic risk factor for rheumatoid arthritis (RA) and for antibiotic-refractory Lyme arthritis (LA). We have developed a novel…

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