Abstracts tagged "lupus nephritis and tumor necrosis factor (TNF)"

Abstract Number: 1833 • 2017 ACR/ARHP Annual Meeting
iRhom2 Deficiency Protects Fcgr2b-/- Lupus-Prone Mice from Kidney Damage By Modulating ADAM17-Dependent Shedding of TNF-α and EGFR Ligand
Xiaoping Qing¹, Yurii Chinenov², Patricia M. Redecha³, Michael Madaio⁴, Priya Issuree⁵, David McIlwain⁶, Tak Mak⁷, Carl Blobel⁵ and Jane E. Salmon⁸, ¹Program in Inflammation and Autoimmunity, Hospital for Special Surgery, New York, NY, ²Arthritis & Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ³Autoimmunity & Inflammation, Hospital for Special Surgery, New York, NY, ⁴Medicine, Medical College of Georgia, Augusta, GA, ⁵Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY, ⁶Department of Microbiology and Immunology, Stanford University, Stanford, CA, ⁷Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Center, Toronto, ON, Canada, ⁸Medicine/Rheumatology, Hospital of Special Surgery, New York, NY
Background/Purpose: A disintegrin and metalloprotease 17 (ADAM17) controls ecto-domain shedding of TNFα and epithelial-growth factor ligands (EGFR) such as heparin-binding EGF (HB-EGF). TNFa and HB-EGF…

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