Abstracts tagged "Lupus nephritis and transcription factor"

Abstract Number: 998 • ACR/ARHP Annual Meeting 2018
Transcription Factor Fli-1 Impacts Renal IL-17 Expression in Adult MRL/Lpr Mouse Despite Similar Interstitial Immune Cell Infiltration into the Kidney
Shuzo Sato¹, Xian Zhang², Yuya Fujita¹, Makiko Yashiro¹, Tomoyuki Asano¹, Hiroko Kobayashi¹, Hiroshi Watanabe¹ and Kiyoshi Migita³, ¹Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, ²Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, ³Fukushima Medical University, School of Medicine, Fukushima, Japan
Background/Purpose: Fli-1 is a member of Ets transcription factor and plays an important role in lupus nephritis development. Reduced Fli-1 expression (heterozygote Fli-1: Fli-1+/-) results…